Alison M Neff,Jodi A Flaws
Alison M Neff
Endocrine disrupting chemicals pose a threat to health and reproduction. Plasticizers such as phthalates and bisphenols are particularly problematic because they are present in many consumer products and exposure can begin in utero and cont...
Sleep and the Testis [0.03%]
睡眠与睾丸功能
Nora A O&#x;Byrne,Fiona Yuen,Warda Niaz et al.
Nora A O&#x;Byrne et al.
Disordered sleep impairs neurocognitive performance, and is now recognized to cause metabolic ill-health. This review assesses the nascent relationship between insufficient, misaligned, and disrupted sleep with andrological health. High-qua...
Transactivation of G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs): Recent insights using luminescence and fluorescence technologies [0.03%]
G蛋白偶联受体(GPCRS)和受体酪氨酸激酶(RTKs)的反式激活：使用发光和荧光技术获得的新见解
Laura E Kilpatrick,Stephen J Hill
Laura E Kilpatrick
Alterations in signalling due to bidirectional transactivation of G protein-coupled receptor (GPCRs) and receptor tyrosine kinases (RTKs) are well established. Transactivation significantly diversifies signalling networks within a cell and ...
Does sex influence the effects of experimental sleep curtailment and circadian misalignment on regulation of appetite? [0.03%]
性对实验性睡眠减少和生物钟失调调节食欲的影响吗？
Julian V Gallegos,Hedda L Boege,Faris M Zuraikat et al.
Julian V Gallegos et al.
Sleep curtailment and circadian misalignment disrupt energy sensing and eating behaviors, which can contribute to weight gain and obesity-related comorbidities. Herein, we review the effects of experimental manipulations of sleep duration a...
Targeting G protein-coupled receptor kinases (GRKs) to G protein-coupled receptors [0.03%]
G蛋白偶联受体激酶(GRKs)向G蛋白偶联受体靶向转运
Sarah M Sulon,Jeffrey L Benovic
Sarah M Sulon
G protein-coupled receptors (GPCRs) interact with three protein families following agonist binding: heterotrimeric G proteins, G protein-coupled receptor kinases (GRKs) and arrestins. GRK-mediated phosphorylation of GPCRs promotes arrestin ...
Diego Grinman,Diana Athonvarungkul,John Wysolmerski et al.
Diego Grinman et al.
Lactation requires a series of adaptations in maternal calcium and bone metabolism to ensure a steady supply of calcium to the lactating mammary gland. The alterations in systemic metabolism are accompanied by alterations in the expression ...
The Relationship between Sleep, Obesity, and Metabolic Health in Adolescents - a Review [0.03%]
青春期睡眠、肥胖和代谢健康的关系——综述文章
Amarachi Okoli,Erin C Hanlon,Matthew J Brady
Amarachi Okoli
In this literature review, we discuss the importance of adequate sleep and the various effects of suboptimal sleep on weight maintenance and metabolic health specifically for adolescents. Two major contributors to adolescents experiencing d...
Interactions between Environmental Exposures and the Microbiome: Implications for Fetal Programming [0.03%]
环境暴露与微生物组的相互作用：对胎儿程序化的意义
Sohini Banerjee,Melissa A Suter,Kjersti M Aagaard
Sohini Banerjee
Decades of population-based health outcomes data highlight the importance of understanding how environmental exposures in pregnancy affect maternal and neonatal outcomes. Animal model research and epidemiological studies have revealed that ...
Intertwined reproductive endocrinology: Puberty and polycystic ovary syndrome [0.03%]
错综复杂的生殖内分泌学：青春期与多囊卵巢综合征
Selma Feldman Witchel,Tony M Plant
Selma Feldman Witchel
Polycystic ovary syndrome (PCOS) is a heterogeneous familial disorder often emerging during the peri-pubertal years concomitantly with the onset of gonadarche and adrenarche. Both gonadarche and PCOS reflect functional changes in the hypoth...
Su-Yi Liew,Scott A Akker,Leonardo Guasti et al.
Su-Yi Liew et al.
Since the original description of adrenal insufficiency by Thomas Addison in 1855, there has been an exponential growth in the understanding of adrenal gland biology and its role in the hypothalamic-pituitary-adrenal axis. Despite this, the...