Glucocorticoid action in the anterior pituitary gland: Insights from corticotroph physiology [0.03%]
糖皮质激素在前腺垂体的作用：来自促肾上腺皮质激素细胞生理的启示
Michael J Shipston
Michael J Shipston
The anterior pituitary is exposed to ultradian, circadian and stress-induced rhythms of circulating glucocorticoid hormones. Glucocorticoids feedback at the level of the pituitary corticotroph to control their own production through multipl...
Analysis of wearable time series data in endocrine and metabolic research [0.03%]
内分泌与代谢研究中可穿戴设备时间序列数据的分析
Azure D Grant,Thomas J Upton,John R Terry et al.
Azure D Grant et al.
Many hormones in the body oscillate with different frequencies and amplitudes, creating a dynamic environment that is essential to maintain health. In humans, disruptions to these rhythms are strongly associated with increased morbidity and...
Duncan J MacGregor
Duncan J MacGregor
Magnocellular oxytocin and vasopressin neurons of the hypothalamus project to the posterior pituitary where they secrete their peptide hormone signals directly into the bloodstream. Their large anatomically distinct secretory mechanisms pro...
Modelling KNDy neurons and gonadotropin-releasing hormone pulse generation [0.03%]
KNDy神经元建模及促性腺激素释放激素脉冲发生机制
Zoe Plain,Margaritis Voliotis,Craig A McArdle et al.
Zoe Plain et al.
The pulsatile release of gonadotropin-releasing hormone (GnRH) and its frequency are crucial for healthy reproductive function. To understand what drives GnRH pulses, a combination of experimental and mathematical modelling approaches has b...
Fast dynamics in the HPA axis: Insight from mathematical and experimental studies [0.03%]
HPA轴中的快速动态变化：来自数学和实验研究的见解
Jamie J Walker,Nicola Romanò
Jamie J Walker
The activity of the hypothalamic-pituitary-adrenal (HPA) axis is characterised by complex dynamics spanning several timescales. This ranges from slow circadian rhythms in blood hormone concentration to faster ultradian pulses of hormone sec...
Intrahypothalamic effects of oxytocin on PVN CRH neurons in response to acute stress [0.03%]
急性应激时下丘脑内的催产素对室旁核CRH神经元的影响
Dipa Pati,Eric G Krause,Charles J Frazier
Dipa Pati
Much of the centrally available oxytocin (OT) is synthesized in magnocellular neurons located in the paraventricular nucleus of the hypothalamus. This same area is home to parvocellular corticotropin-releasing hormone (CRH) synthesizing neu...
Ying Sze,Paula J Brunton
Ying Sze
Early-life stress can lead to detrimental offspring outcomes, including an increased risk for mood disorders and hypothalamic-pituitary-adrenal axis dysregulation. Neurosteroids bind to ligand-gated neurotransmitter receptors, rapidly modul...
Stressed and wired: The effects of stress on the VTA circuits underlying motivated behavior [0.03%]
紧张不安：压力对控制动机行为的VTA神经回路的影响
Daniel C Lowes,Alexander Z Harris
Daniel C Lowes
Stress affects many brain regions, including the ventral tegmental area (VTA), which is critically involved in reward processing. Excessive stress can reduce reward-seeking behaviors but also exacerbate substance use disorders, two seemingl...
Pituitary corticotroph identity and receptor-mediated signaling: a transcriptomics perspective [0.03%]
垂体促肾上腺皮质激素生成细胞的身份及其受体介导的信号转导：一种基因表达谱的观点
Stanko S Stojilkovic,Rafael M Previde,Arthur S Sherman et al.
Stanko S Stojilkovic et al.
Recent single-cell RNA sequencing has offered an unprecedented view of pituitary cell transcriptomic profiles. In this review, these new data are briefly discussed and compared with the classical literature, focusing on pituitary corticotro...
Data integration and mechanistic modelling for breast cancer biology: Current state and future directions [0.03%]
乳腺癌生物学的数据整合与机制建模：现状及未来方向
Hanyi Mo,Rainer Breitling,Chiara Francavilla et al.
Hanyi Mo et al.
Breast cancer is one of the most common cancers threatening women worldwide. A limited number of available treatment options, frequent recurrence, and drug resistance exacerbate the prognosis of breast cancer patients. Thus, there is an urg...