Brain mineralocorticoid and glucocorticoid receptor balance in neuroendocrine regulation and stress-related psychiatric etiopathologies [0.03%]
与神经内分泌调节和应激相关的精神病发病机制有关的脑矿物质皮质激素受体和糖皮质激素受体平衡
Edo Ronald de Kloet
Edo Ronald de Kloet
Cortisol and corticosterone (CORT) coordinate circadian events and manage the stress response by differential activation of two complementary brain receptor systems, i.e., the mineralocorticoid receptor (MR) and the glucocorticoid receptor ...
InTERTwined: how TERT promoter mutations impact BRAFV600E-driven thyroid cancers [0.03%]
交织：TERT启动子突变如何影响BRAF(V600E)驱动的甲状腺癌
Iñigo Landa
Iñigo Landa
Thyroid cancers are often initiated by the acquisition of a BRAFV600E mutation. BRAFV600E-driven thyroid tumors display a wide range of behaviors, from the slow-growing papillary carcinomas to the highly aggressive anaplastic. Mutations in ...
Evidence in Humans for Bone as an Endocrine Organ Regulating Energy Metabolism [0.03%]
人骨骼作为内分泌组织调节能量代谢的证据
Sundeep Khosla
Sundeep Khosla
There is increasing evidence from animal models that bone, in addition to its traditional function of providing structural support for the organism, has a rich network of interactions with multiple other tissues. This perspective focuses on...
Samar R El Khoudary,Alexis Nasr
Samar R El Khoudary
It is known that the menopause transition (MT) is a complex period during a woman's life, but there has been ongoing debate on whether the increase in cardiovascular disease (CVD) during midlife is due to chronological aging or ovarian agin...
Mary Y Carson,Rebecca C Thurston
Mary Y Carson
Hot flashes and night sweats, also known as vasomotor symptoms (VMS), are common and bothersome symptoms of the menopause transition. In addition to negatively impacting quality of life, VMS have been associated with multiple indicators of ...
Premature Ovarian Insufficiency [0.03%]
卵巢早衰
Ekta Kapoor
Ekta Kapoor
Natural menopause typically occurs between the ages of 46 to 55 years. Premature ovarian insufficiency or premature menopause refers to compromised ovarian follicular activity, occurring spontaneously or because of medical interventions, pr...
Pleiotropic endophenotypic and phenotype effects of GABAergic neurosteroid synthesis deficiency in posttraumatic stress disorder [0.03%]
PTSD中谷氨酸神经甾体合成缺乏的多效性表型和内表型效应
Ann M Rasmusson,Olga Novikov,Kayla D Brown et al.
Ann M Rasmusson et al.
PTSD is associated with deficits in synthesis of progesterone metabolites such as allopregnanolone and pregnanolone that potently facilitate gamma-amino-butyric acid (GABA) effects at GABAA receptors. These neurosteroids modulate neuronal f...
Ryan C Riddle
Ryan C Riddle
Sclerostin, the product of the SOST gene has primarily been studied for its profound impact on bone mass. By interacting with LRP5 and LRP6, the glycoprotein suppresses the propagation of Wnt signals to β-catenin and thereby suppresses new...
Margaritis Voliotis,Simon Hanassab,Ali Abbara et al.
Margaritis Voliotis et al.
Understanding the human hypothalamic-pituitary-gonadal (HPG) axis presents a major challenge for medical science. Dysregulation of the HPG axis is linked to infertility and a thorough understanding of its dynamic behaviour is necessary to b...
Zebrafish as a model to investigate the CRH axis and interactions with DISC1 [0.03%]
斑马鱼作为研究CRH轴及其与DISC1相互作用的模型
Helen Eachus,Soojin Ryu,Marysia Placzek et al.
Helen Eachus et al.
Release of corticotropin-releasing hormone (CRH) from CRH neurons activates the hypothalamo-pituitary-adrenal (HPA) axis, one of the main physiological stress response systems. Complex feedback loops operate in the HPA axis and understandin...