Nathalia de Lima E Martins Lara,Anja Elsenhans,Rkia Dardari et al.
Nathalia de Lima E Martins Lara et al.
A better understanding of the role primary cilia play in the testis is becoming increasingly important in the context of male reproductive health since defects in cilia have been associated with male infertility and reproductive disorders. ...
Remodeling the marrow fat niche: BMAT in cancer bone metastases and hematological malignancies [0.03%]
重塑骨髓脂肪生态 niche：癌骨转移和血液系统恶性肿瘤中的BMAT功能
Izabela Podgorski
Izabela Podgorski
Bone marrow adipose tissue (BMAT) is a dynamic component of the marrow microenvironment that influences tumor persistence, therapy response, and skeletal integrity. Recent work shows that marrow adipocytes function not only as metabolic par...
Erythropoietin and Skeletal Cells CrossTalks in Physiology and Disease [0.03%]
促红细胞生成素与骨细胞生理和疾病中的相互作用机制研究
Giulia Lanzolla,Mohd Parvez Khan,Elena Sabini et al.
Giulia Lanzolla et al.
The hypoxia-inducible factor 2alpha (HIF-2), which is a member of the HIF family of transcription factors and a critical component of the hypoxia-driven pathway, regulates adult erythropoiesis through the renal production and secretion of e...
Courtney M Karner,Fanxin Long
Courtney M Karner
Osteoblasts are the chief bone-making cells that specialize in producing and mineralizing large amounts of type I collagen and other matrix proteins. The bioenergetics in support of the energy-intensive osteoblast activity is not well under...
Bone Marrow Skeletal Stem Cell Dysfunction: Adipocytes during skeletal aging and senescence [0.03%]
骨髓间充质干细胞功能障碍：骨骼衰老过程中的脂肪细胞分化
Aqsa Komel,David Achudhan,Abhishek Chandra
Aqsa Komel
The cell fate regulation of skeletal stem cells (SSCs) into bone marrow adipocytes (BMAd) during physiological and pathological conditions has been a subject of study. Identification, isolation, and characterization of progenitors that give...
Adiponectin expressing skeletal stem/progenitor cells in the bone and bone marrow homeostasis [0.03%]
骨和骨髓稳态中的脂肪素表达骨骼干细胞/前体细胞
Biagio Palmisano,Alessandro Corsi,Mara Riminucci
Biagio Palmisano
The bone marrow stroma supports hematopoiesis while replenishing osteoblasts and adipocytes. These functions rely on different stromal cell populations identified by lineage tracing, phenotypic markers and single-cell transcriptomic analysi...
Therapeutic treatments targeting communication between angiogenic and immune microenvironments in thyroid cancers [0.03%]
针对甲状腺癌血管生成和免疫微环境之间通讯的治疗措施
Alessandro Prete,Carmelo Nucera
Alessandro Prete
Thyroid cancer treatment has recently been revolutionized by the introduction of specific targeted therapies (e.g. BRAFV600E or highly selective RET inhibitors), anti-angiogenic agents (e.g. tyrosine kinase inhibitors (TKIs)) and immune che...
Attenuation of adipose tissue inflammation by pro-resolving lipid mediators [0.03%]
前列腺素介质缓解脂肪组织炎症反应
Madison Clark,Bianca E Suur,Matúš Soták et al.
Madison Clark et al.
Adipose tissue inflammation drives systemic pathophysiology, for instance, obesity-related cardiometabolic disease. Specialized pro-resolving lipid mediators are a superfamily of endogenously produced lipids that promote the resolution of i...
Paraventricular nucleus-Medullary interactions: How they help enable endocrine responses to metabolic stress [0.03%]
室管膜下核-脑干相互作用：它们如何帮助内分泌应对代谢压力反应
Alan G Watts
Alan G Watts
The paraventricular hypothalamic nucleus (PVH) organizes neuroendocrine and autonomic responses to rapidly and slowly developing metabolic stressors that limit their impact on energy balance. The PVH together with the lateral hypothalamic a...
How preclinical models of menopause can inform clinical care: A focus on midlife and reciprocal communication between clinical and preclinical science [0.03%]
绝经前临床模型如何改善临床护理：注重中年和临床与前临床科学的相互交流
Heather A Bimonte-Nelson,Victoria E Bernaud
Heather A Bimonte-Nelson
Midlife in women typically includes the menopausal transition, a time of hormonal transformation, adaptation, and reorganization. Coincident with this dynamic period of physiological change, there are putatively modifiable factors that infl...