A ZDHHC5-GOLGA7 Protein Acyltransferase Complex Promotes Nonapoptotic Cell Death [0.03%]
一个ZDHHC5-GOLGA7蛋白酰基转移酶复合体促进非凋亡性细胞死亡
Pin-Joe Ko,Claire Woodrow,Michael M Dubreuil et al.
Pin-Joe Ko et al.
Lethal small molecules are useful probes to discover and characterize novel cell death pathways and biochemical mechanisms. Here we report that the synthetic oxime-containing small molecule caspase-independent lethal 56 (CIL56) induces an u...
A Fluorogenic RNA-Based Sensor Activated by Metabolite-Induced RNA Dimerization [0.03%]
一种由代谢物诱导的RNA二聚化激活的荧光RNA传感器
Hyaeyeong Kim,Samie R Jaffrey
Hyaeyeong Kim
Corn is a fluorogenic RNA aptamer that forms a high-affinity quasi-symmetric homodimer. The Corn dimer interface binds DFHO, resulting in highly photostable yellow fluorescence. Because of its photostability, Corn would be useful in RNA-bas...
Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany [0.03%]
蛋白化学展望：第八届化学蛋白质合成会议 2019年6月16-19日，德国柏林
Claudia Bello,Nina Hartrampf,Louise J Walport et al.
Claudia Bello et al.
The 8th Chemical Protein Synthesis meeting took place in Berlin in June 2019, covering broad topics in protein chemistry, ranging from synthetic methodology to applications in medicine and biomaterials. The meeting was also the culmination ...
Leo E Otterbein
Leo E Otterbein
In this issue of Cell Chemical Biology, Vasavda et al. (2019) present data supporting a neuroprotective role for bilirubin, a bioactive product resulting from heme degradation. While the antioxidant capability of bilirubin is well documente...
Venkateswarlu Yarlagadda,Gerard D Wright
Venkateswarlu Yarlagadda
In this issue of Cell Chemical Biology, Radlinski et al. (2019) identify Pseudomonas-derived rhamnolipids that potentiate aminoglycoside antibiotics in the eradication of antibiotic-tolerant bacterial phenotypes. Microbial physiological and...
Responsive Antibody Conjugates Enable Quantitative Determination of Intracellular Bond Degradation Rate [0.03%]
响应性抗体结合物能够定量确定胞内键降解速率
Michelle R Sorkin,Joshua A Walker,Sneha R Kabaria et al.
Michelle R Sorkin et al.
Degradable crosslinkers that respond to intracellular biological stimuli are a critical component of many drug delivery systems. With numerous stimuli-responsive drug delivery systems in development, it is important to quantitatively study ...
A Catalytic Trisulfide in Human Sulfide Quinone Oxidoreductase Catalyzes Coenzyme A Persulfide Synthesis and Inhibits Butyrate Oxidation [0.03%]
人类硫化物辅酶Q氧化还原酶中的催化三硫化物可合成泛酸焦硫酸酯并抑制丁酸氧化
Aaron P Landry,Sojin Moon,Hanseong Kim et al.
Aaron P Landry et al.
Mitochondrial sulfide quinone oxidoreductase (SQR) catalyzes the oxidation of H2S to glutathione persulfide with concomitant reduction of CoQ10. We report herein that the promiscuous activity of human SQR supported the conversion of CoA to ...
Family-wide Annotation of Enzymatic Pathways by Parallel In Vivo Metabolomics [0.03%]
基于并行体内代谢组学的酶催化途径泛家族注释
Joon T Kim,Veronica L Li,Stephanie M Terrell et al.
Joon T Kim et al.
Enzymes catalyze fundamental biochemical reactions that control cellular and organismal homeostasis. Here we present an approach for de novo biochemical pathway discovery across entire mammalian enzyme families using parallel viral transduc...
Beyond DPPH: Use of Fluorescence-Enabled Inhibited Autoxidation to Predict Oxidative Cell Death Rescue [0.03%]
超越DPPH：利用荧光抑制自动氧化法预测抗氧化物质拯救氧化性细胞死亡的能力
Ron Shah,Luke A Farmer,Omkar Zilka et al.
Ron Shah et al.
"Antioxidant activity" is an often invoked, but generally poorly characterized, molecular property. Several assays are available to determine antioxidant activity, the most popular of which is based upon the ability of a putative antioxidan...
A Highly Efficient CRISPR-Cas9-Based Genome Engineering Platform in Acinetobacter baumannii to Understand the H2O2-Sensing Mechanism of OxyR [0.03%]
高效CRISPR-Cas9基因编辑平台揭秘baumannii菌H2O2感知机制
Yu Wang,Zhipeng Wang,Yan Chen et al.
Yu Wang et al.
The rapid emergence of extensively drug-resistant A. baumannii has posed a major threat to global public health, emphasizing the desperate need for novel therapeutic strategies. We report the development of a highly efficient genome-enginee...