SFPQ Is an FTO-Binding Protein that Facilitates the Demethylation Substrate Preference [0.03%]
SFPQ是FTO结合蛋白，可促进脱甲基底物优先选择
Haiping Song,Ye Wang,Ruixiang Wang et al.
Haiping Song et al.
The fat mass and obesity-associated protein (FTO) is the first identified demethylase of the internal RNA modification N6-methyladenosine (m6A), which also exhibits demethylation activity toward N6,2'-O-dimethyladenosine (m6Am) and N1-methy...
A Toxic RNA Catalyzes the Cellular Synthesis of Its Own Inhibitor, Shunting It to Endogenous Decay Pathways [0.03%]
一种有毒RNA催化的其自身的抑制物的细胞合成，将其移至内源性衰变途径中
Raphael I Benhamou,Alicia J Angelbello,Eric T Wang et al.
Raphael I Benhamou et al.
Myotonic dystrophy type 2 (DM2) is a genetically defined disease caused by a toxic expanded repeat of r(CCUG) [r(CCUG)exp], harbored in intron 1 of CCHC-type zinc-finger nucleic acid binding protein (CNBP) pre-mRNA. This r(CCUG)exp causes t...
The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites [0.03%]
抗疟类天然产物Salinipostin A鉴别出恶性疟原虫中参与脂质代谢的必需α/β丝氨酸水解酶
Euna Yoo,Christopher J Schulze,Barbara H Stokes et al.
Euna Yoo et al.
Salinipostin A (Sal A) is a potent antiplasmodial marine natural product with an undefined mechanism of action. Using a Sal A-derived activity-based probe, we identify its targets in the Plasmodium falciparum parasite. All of the identified...
Zuzanna Kozicka,Georg Petzold,Nicolas H Thomä
Zuzanna Kozicka
PCSK9 heightens LDL cholesterol levels by chaperoning the liver LDL receptor to lysosomes for degradation. In this issue of Cell Chemical Biology, Petrilli et al. (2020) identify novel PCSK9 ligands and convert them into a proof-of-concept ...
Martin G Jaeger,Georg E Winter
Martin G Jaeger
In this issue of Cell Chemical Biology, Li et al. (2020), Hsu et al. (2020), and Potjewyd et al. (2020) expand the target spectrum amenable to protein degradation by designing degraders of the cell cycle checkpoint kinase Wee1 and the polyc...
Douglas R Green
Douglas R Green
In this issue of Cell Chemical Biology, Ko et al. (2019) describe a form of regulated necrosis that depends on active, retrograde transport of vesicles from the plasma membrane to the Golgi. The cell death is distinct from defined modalitie...
An Axonal Blueprint: Generating Neuronal Polarity with Light-Inducible Proteins [0.03%]
光照诱导蛋白生成神经元极性的轴突图谱
Michael Z Lin
Michael Z Lin
In this issue of Cell Chemical Biology, Woo et al. (2019) show that activation of a photoinducible form of the TrkB protein in a single neurite induces multiple aspects of axonal differentiation. This study exemplifies the ability of optica...
Severing Ties: Quantifying the Payload Release from Antibody Drug Conjugates [0.03%]
切断联系：量化抗体药物偶联物的载荷释放
Anna Kopp,Greg M Thurber
Anna Kopp
As a key mediator of efficacy and toxicity, the linker connecting the payload in antibody drug conjugates determines cellular distribution and payload release. Sorkin et al. (2019) have created novel fluorescence-based linkers to quantify t...
Overcoming Fungal Echinocandin Resistance through Inhibition of the Non-essential Stress Kinase Yck2 [0.03%]
通过抑制非必需应激蛋白激酶Yck2克服真菌棘白霉素抗性
Tavia Caplan,Álvaro Lorente-Macías,Peter J Stogios et al.
Tavia Caplan et al.
New strategies are urgently needed to counter the threat to human health posed by drug-resistant fungi. To explore an as-yet unexploited target space for antifungals, we screened a library of protein kinase inhibitors for the ability to rev...
Myeloid Cell-Targeted Nanocarriers Efficiently Inhibit Cellular Inhibitor of Apoptosis for Cancer Immunotherapy [0.03%]
针对髓系细胞的纳米载体高效抑制凋亡抑制蛋白用于癌症免疫治疗
Peter D Koch,Christopher B Rodell,Rainer H Kohler et al.
Peter D Koch et al.
Immune-checkpoint blockers can promote sustained clinical responses in a subset of cancer patients. Recent research has shown that a subpopulation of tumor-infiltrating dendritic cells functions as gatekeepers, sensitizing tumors to anti-PD...