Brent R Stockwell,Xuejun Jiang
Brent R Stockwell
Ferroptosis is a recently described form of cell death driven by iron-dependent lipid peroxidation. This type of cell death was first observed in response to treatment of tumor cells with a small-molecule chemical probe named erastin. Most ...
Marcus Conrad,Bettina Proneth
Marcus Conrad
The trace elements iron and selenium play decisive roles in a distinct form of necrotic cell death, known as ferroptosis. While iron promotes ferroptosis by contributing to Fenton-type reactions and uncontrolled lipid autoxidation, the hall...
Achieving Life through Death: Redox Biology of Lipid Peroxidation in Ferroptosis [0.03%]
通过死亡实现生命：铁死亡中的脂质过氧化还原生物学
Hülya Bayır,Tamil S Anthonymuthu,Yulia Y Tyurina et al.
Hülya Bayır et al.
Redox balance is essential for normal brain, hence dis-coordinated oxidative reactions leading to neuronal death, including programs of regulated death, are commonly viewed as an inevitable pathogenic penalty for acute neuro-injury and neur...
Breakdown of an Ironclad Defense System: The Critical Role of NRF2 in Mediating Ferroptosis [0.03%]
铁死亡中的NRF2通路：铁死亡的铁打不动的防御系统的瓦解
Annadurai Anandhan,Matthew Dodson,Cody J Schmidlin et al.
Annadurai Anandhan et al.
Ferroptosis is a non-apoptotic mode of regulated cell death that is iron and lipid peroxidation dependent. As new mechanistic insight into ferroptotic effectors and how they are regulated in different disease contexts is uncovered, our unde...
Cellular Stress Upregulates Indole Signaling Metabolites in Escherichia coli [0.03%]
胞内压力通过上调色氨酸代谢产物调节大肠杆菌的吲哚信号分子水平
Chung Sub Kim,Jhe-Hao Li,Brenden Barco et al.
Chung Sub Kim et al.
Escherichia coli broadly colonize the intestinal tract of humans and produce a variety of small molecule signals. However, many of these small molecules remain unknown. Here, we describe a family of widely distributed bacterial metabolites ...
Rajiv R Ratan
Rajiv R Ratan
Over the past five decades, thanatology has come to include the study of how individual cells in our bodies die appropriately and inappropriately in response to physiological and pathological stimuli. Morphological and biochemical criteria ...
Site-Specific Photo-Crosslinking Proteomics Reveal Regulation of IFITM3 Trafficking and Turnover by VCP/p97 ATPase [0.03%]
位点特异性光交联蛋白质组学揭示VCP/p97 ATP酶对IFITM3转运和更新的调控作用
Xiaojun Wu,Jennifer S Spence,Tandrila Das et al.
Xiaojun Wu et al.
Interferon-induced transmembrane protein 3 (IFITM3) is a key interferon effector that broadly prevents infection by diverse viruses. However, the cellular factors that control IFITM3 homeostasis and antiviral activity have not been fully el...
Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth [0.03%]
多靶标扰动14-3-3接头蛋白互作组促进轴突生长
Andrew Kaplan,Sebastian A Andrei,Anna van Regteren Altena et al.
Andrew Kaplan et al.
Targeting protein-protein interactions (PPIs) is a promising approach in the development of drugs for many indications. 14-3-3 proteins are a family of phosphoprotein-binding molecules with critical functions in dozens of cell signaling net...
David A Armenta,Scott J Dixon
David A Armenta
Nonapoptotic cell death is important for human health and disease. Here, we show how various tools and techniques drawn from the chemical biology field have played a central role in the discovery and characterization of nonapoptotic cell de...
Development of Potent, Selective Surrogate WNT Molecules and Their Application in Defining Frizzled Requirements [0.03%]
potent、选择性代理WNT分子的发展及其在定义Frizzled需求中的应用
Hui Chen,Chenggang Lu,Brian Ouyang et al.
Hui Chen et al.
WNTs regulate myriad biological processes during embryonic development and are key regulators of stem cell function, tissue homeostasis, and injury repair in adults. The creation of WNT-based therapies has been hampered by challenges in dev...