Haiming Dai,X Wei Meng,Scott H Kaufmann
Haiming Dai
In this issue of Cell Chemical Biology, Harvey et al. (2020) identify 4E14, a sulfhydryl-containing N-acetyltryptophan analog that selectively disrupts binding to the previously undruggable anti-apoptotic BCL2 paralog BFL1, and elucidate a ...
Yan Zi Au,Tingjian Wang,Logan H Sigua et al.
Yan Zi Au et al.
Qu et al. (2020) demonstrate a peptide-induced targeted degradation of the alpha-synuclein protein, a hallmark of Parkinson's disease. Using a modular three-component design, the target-protein-specific, cell-permeable peptide disposed of a...
Fusicoccin Keeps Getting Stickier: Modulation of an Adaptor Protein Interactome with a Molecular Glue Leads to Neurite Outgrowth [0.03%]
茯苓素不断“粘”下来：分子胶调控一个适配蛋白相互作用组促进神经突生长
Claire S Harmange Magnani,Thomas J Maimone
Claire S Harmange Magnani
Many traditional drugs inhibit enzyme function; in contrast, some naturally "sticky" small molecules can stabilize protein-protein interactions. In this issue of Cell Chemical Biology, Kaplan et al. (2020) explore regulation of the 14-3-3 i...
tRNAArg-Derived Fragments Can Serve as Arginine Donors for Protein Arginylation [0.03%]
tRNA(Arg)衍生的片段可以作为蛋白质精酰化作用的氮基供体
Irem Avcilar-Kucukgoze,Howard Gamper,Christine Polte et al.
Irem Avcilar-Kucukgoze et al.
Arginyltransferase ATE1 mediates posttranslational arginylation and plays key roles in multiple physiological processes. ATE1 utilizes arginyl (Arg)-tRNAArg as the donor of Arg, putting this reaction into a direct competition with the prote...
A Photo-clickable ATP-Mimetic Reveals Nucleotide Interactors in the Membrane Proteome [0.03%]
一种可点击的照片ATP-拟似物揭示了膜蛋白质组中的核苷酸相互作用者
Mark Jelcic,Ke Wang,King Lam Hui et al.
Mark Jelcic et al.
ATP is an important energy metabolite and allosteric signal in health and disease. ATP-interacting proteins, such as P2 receptors, control inflammation, cell death, migration, and wound healing. However, identification of allosteric ATP sit...
Stephan A Sieber,Silvia Cappello,Pavel Kielkowski
Stephan A Sieber
Protein post-translational modifications (PTMs) are implicated in numerous physiological processes and significantly contribute to complex regulatory networks of protein functions. Recently, a protein PTM called AMPylation was found to play...
An Isoform-Selective Modulator of Cryptochrome 1 Regulates Circadian Rhythms in Mammals [0.03%]
一种CRY1异构体选择性调节剂可调控哺乳动物的昼夜节律
Simon Miller,Yoshiki Aikawa,Akiko Sugiyama et al.
Simon Miller et al.
Cryptochrome 1 (CRY1) and CRY2 are core regulators of the circadian clock, and the development of isoform-selective modulators is important for the elucidation of their redundant and distinct functions. Here, we report the identification an...
A Clickable APEX Probe for Proximity-Dependent Proteomic Profiling in Yeast [0.03%]
用于酵母近距离依赖性蛋白质组分析的可点击APEX探针
Yi Li,Caiping Tian,Keke Liu et al.
Yi Li et al.
The engineered ascorbate peroxidase (APEX) is a powerful tool for the proximity-dependent labeling of proteins and RNAs in live cells. Although widely use in mammalian cells, APEX applications in microorganisms have been hampered by the poo...
Structural Basis for the Binding Selectivity of Human CDY Chromodomains [0.03%]
人CDY染色体结构域结合选择性的结构基础
Cheng Dong,Yanli Liu,Tian-Jie Lyu et al.
Cheng Dong et al.
The CDY (chromodomain on the Y) proteins play an essential role in normal spermatogenesis and brain development. Dysregulation of their expression has been linked to male infertility and various neurological diseases. Like the chromodomains...
Enhancing the Antiviral Efficacy of RNA-Dependent RNA Polymerase Inhibition by Combination with Modulators of Pyrimidine Metabolism [0.03%]
利用嘧啶代谢调节剂增效RNA依赖型RNA聚合酶抑制的抗病毒作用
Qi Liu,Amita Gupta,Ayse Okesli-Armlovich et al.
Qi Liu et al.
Genome-wide analysis of the mode of action of GSK983, a potent antiviral agent, led to the identification of dihydroorotate dehydrogenase as its target along with the discovery that genetic knockdown of pyrimidine salvage sensitized cells t...