Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders [0.03%]
选择性靶向神经母细胞瘤N-Myc的Aurora激酶A降解剂
Jian Tang,Ramkumar Moorthy,Laura E Hirsch et al.
Jian Tang et al.
The N-Myc transcription factor, encoded by MYCN, is a mechanistically validated, yet challenging, target for neuroblastoma (NB) therapy development. In normal neuronal progenitors, N-Myc undergoes rapid degradation, while, in MYCN-amplified...
The right tool for the job: Chemical biology and microbiome science [0.03%]
工欲善其事，必先利其器——化学生物学与微生物组学研究
Christopher Whidbey
Christopher Whidbey
Microbiomes exist in ecological niches ranging from the ocean and soil to inside of larger organisms like plants and animals. Within these niches, microbes play key roles in biochemical processes that impact larger phenomena, such as biogeo...
The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells [0.03%]
外排泵ABCC1/MRP1固有地限制癌细胞中PROTAC的敏感性
Gernot Wolf,Conner Craigon,Shao Thing Teoh et al.
Gernot Wolf et al.
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting "undruggable" proteins, and...
Development of an FKBP12-recruiting chemical-induced proximity DNA-encoded library and its application to discover an autophagy potentiator [0.03%]
一种FKBP12-募集型分子胶诱导的接近亲和筛选DNA编码化合物库的发展及其在发现自噬增强剂中的应用
Zher Yin Tan,Joel K A Adade,Xiebin Gu et al.
Zher Yin Tan et al.
Chemical inducers of proximity (CIPs) are molecules that recruit one protein to another and introduce new functionalities toward modulating protein states and activities. While CIP-mediated recruitment of E3 ligases is widely exploited for ...
Calcineurin: An essential regulator of sleep revealed by biochemical, chemical biological, and genetic approaches [0.03%]
蛋白磷酸酶(calcineurin)：通过生化、化学遗传及正向遗传学手段发现的一个睡眠关键调节因子
Jianjun Yu,Huijie Liu,Rui Gao et al.
Jianjun Yu et al.
Research into mechanisms underlying sleep traditionally relies on electrophysiology and genetics. Because sleep can only be measured on whole animals by behavioral observations and physical means, no sleep research was initiated by biochemi...
Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen [0.03%]
通过多重筛选发现的一种假单胞菌特异性小分子化合物可靶向外膜蛋白OprH-脂多糖相互作用
Bradley E Poulsen,Thulasi Warrier,Sulyman Barkho et al.
Bradley E Poulsen et al.
The surge of antimicrobial resistance threatens efficacy of current antibiotics, particularly against Pseudomonas aeruginosa, a highly resistant gram-negative pathogen. The asymmetric outer membrane (OM) of P. aeruginosa combined with its a...
Anti-tumor immunotherapy using engineered bacterial outer membrane vesicles fused to lysosome-targeting chimeras mediated by transferrin receptor [0.03%]
基于转铁蛋白受体介导的融合溶酶体靶向嵌合体的工程化细菌外膜囊泡抗肿瘤免疫治疗研究
Ling-Yan Su,Yang Tian,Qiang Zheng et al.
Ling-Yan Su et al.
Published Erratum
Cell chemical biology. 2024 Dec 24:S2451-9456(24)00520-8. DOI:10.1016/j.chembiol.2024.12.008 2024
Spenser H Stone,Jeffrey C Rathmell,Jackie E Bader
Spenser H Stone
Obesity is a leading risk factor and a negative prognostic indicator for many cancers. In a recent issue of Science Immunology, Bagchi et al. identified that tumor-associated macrophages upregulate GPR65 in response to obesity-driven intrat...
Franciscus Chandra,Elaine Y Hsiao
Franciscus Chandra
The molecular underpinnings behind the diet-microbiome-host health relationship are largely undescribed. In a recent issue of Science, Cheng et al.1 uncovered one piece of the puzzle by describing a novel fatty acid amide hydrolase (FAAH) d...
Lei Wang,Wen Zhou
Lei Wang
Novel inhibitors of pyroptosis promise breakthroughs in treating inflammatory diseases and malignant tumors. In this issue of Cell Chemical Biology, Hu et al.1 identify two repurposed drugs that selectively target gasdermin D (GSDMD) oligom...