Re-awakening Innate Immune Signaling in Cancer: The Development of Highly Potent ENPP1 Inhibitors [0.03%]
在癌症中重新激活先天性免疫信号：开发高效ENPP1抑制剂
Derek Cogan,Samuel F Bakhoum
Derek Cogan
Activation of innate immune signaling in the tumor microenvironment is central to a successful anti-tumor immune response, and it is in large part mediated by cytosolic double-stranded DNA sensing. Here, Carozza et al. (2020b) report potent...
Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis [0.03%]
结合基因组挖掘和诱变合成产生抗绿脓杆菌感染的氟化多铜化合物Amychelins类铁载体抗生素
Feng Xie,Shengwang Dai,Yu Zhao et al.
Feng Xie et al.
Pioneering microbial genomic surveys have revealed numerous untapped biosynthetic gene clusters, unveiling the great potential of new natural products. Here, using a combination of genome mining, mutasynthesis, and activity screening in an ...
Discovery of an Inhibitor for Bacterial 3-Mercaptopyruvate Sulfurtransferase that Synergistically Controls Bacterial Survival [0.03%]
一种协同控制细菌存活的细菌3-巯基丙酮酸硫转移酶抑制剂的发现
Giorgia Croppi,Yueyang Zhou,Rong Yang et al.
Giorgia Croppi et al.
H2S-producing enzymes in bacteria have been shown to be closely engaged in the process of microbial survival and antibiotic resistance. However, no inhibitors have been discovered for these enzymes, e.g., 3-mercaptopyruvate sulfurtransferas...
Characterization of Small-Molecule-Induced Changes in Parkinson's-Related Trafficking via the Nedd4 Ubiquitin Signaling Cascade [0.03%]
帕金森病相关泛素信号转导过程中小分子引起的变化的特征描述
A Katherine Hatstat,Hannah D Ahrendt,Matthew W Foster et al.
A Katherine Hatstat et al.
The benzdiimidazole NAB2 rescues α-synuclein-associated trafficking defects associated with early onset Parkinson's disease in a Nedd4-dependent manner. Despite identification of E3 ubiquitin ligase Nedd4 as a putative target of NAB2, its ...
Using the Oxytosis/Ferroptosis Pathway to Understand and Treat Age-Associated Neurodegenerative Diseases [0.03%]
利用 oxytosis/ferroptosis 途径理解和治疗年龄相关的神经退行性疾病
Pamela Maher,Antonio Currais,David Schubert
Pamela Maher
Oxytosis was first described over 30 years ago in nerve cells as a non-excitotoxic pathway for glutamate-induced cell death. The key steps of oxytosis, including glutathione depletion, lipoxygenase activation, reactive oxygen species accumu...
A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex [0.03%]
结合RNA重复扩张的小分子通过 exonuce酶复合物刺激其衰减
Alicia J Angelbello,Raphael I Benhamou,Suzanne G Rzuczek et al.
Alicia J Angelbello et al.
Many diseases are caused by toxic RNA repeats. Herein, we designed a lead small molecule that binds the structure of the r(CUG) repeat expansion [r(CUG)exp] that causes myotonic dystrophy type 1 (DM1) and Fuchs endothelial corneal dystrophy...
Regulation of Calcium Oscillations in β-Cells by Co-activated Cannabinoid Receptors [0.03%]
大麻素受体共激活调节β细胞的钙振荡
Aurélien Laguerre,Kaya Keutler,Sebastian Hauke et al.
Aurélien Laguerre et al.
Pharmacological treatment of pancreatic β cells targeting cannabinoid receptors 1 and 2 (CB1 and CB2) has been shown to result in significant effects on insulin release, possibly by modulating intracellular calcium levels ([Ca2+]i). It is ...
Combined Omics Approaches Reveal the Roles of Non-canonical WNT7B Signaling and YY1 in the Proliferation of Human Pancreatic Progenitor Cells [0.03%]
结合组学方法揭示非经典WNT7B信号通路和YY1在人胰腺祖细胞增殖中的作用
Azuma Kimura,Taro Toyoda,Mio Iwasaki et al.
Azuma Kimura et al.
The proliferation of human pancreatic progenitor cells (PPCs) is critical for developing cell therapies for diabetes. Here, using transcriptome analysis combined with small interfering RNA (siRNA) screening, we revealed that WNT7B is a down...
Photoswitchable CAR-T Cell Function In Vitro and In Vivo via a Cleavable Mediator [0.03%]
基于可裂解介导的光控CAR-T细胞的体内外活性调控
Bo Zhang,Yan Wang,Shenlong Huang et al.
Bo Zhang et al.
Chimeric antigen receptor (CAR)-T-based therapeutics are a breakthrough in cancer treatment; however, they are hampered by constitutive activation, which leads to worrisome side effects. Engineering CAR-T cells to be as tightly controllable...
HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins [0.03%]
HSP90抑制通过调节多个免疫检查点蛋白的表面表达来增强癌症免疫治疗
Reza Beheshti Zavareh,Stephan H Spangenberg,Ashley Woods et al.
Reza Beheshti Zavareh et al.
Cancer immunotherapies, including immune checkpoint blockade, have the potential to significantly impact treatments for diverse tumor types. At present, response failures and immune-related adverse events remain significant issues, which co...