A genetically encoded fluorescent biosensor for visualization of acetyl-CoA in live cells [0.03%]
用于活细胞中可视化乙酰辅酶A的遗传编码荧光生物传感器
Joseph J Smith,Taylor R Valentino,Austin H Ablicki et al.
Joseph J Smith et al.
Acetyl-coenzyme A is a central metabolite that participates in many cellular pathways. Evidence suggests that acetyl-CoA metabolism is highly compartmentalized in mammalian cells. Yet methods to measure acetyl-CoA in living cells are lackin...
SynPull: An advanced method for studying neurodegeneration-related aggregates in synaptosomes using super-resolution microscopy [0.03%]
基于超分辨率显微镜的SynPull方法研究突触体中与神经退行性疾病相关的聚集物
Shekhar Kedia,Emre Fertan,Yunzhao Wu et al.
Shekhar Kedia et al.
Synaptic dysfunction is a primary hallmark of both Alzheimer's and Parkinson's disease, leading to cognitive and behavioral decline. While alpha-synuclein, beta-amyloid, and tau are involved in the physiological functioning of synapses, the...
Dingjiacheng Jia,Shujie Chen
Dingjiacheng Jia
In this issue of Cell Chemical Biology, Rebeck et al.1 construct a system that enables Saccharomyces cerevisiae var. boulardii (Sb) to secrete immune checkpoint inhibitors, reducing intestinal tumor load. This safe and effective delivery pl...
Judith Behnsen,Kerwyn Casey Huang,Matthew T Sorbara et al.
Judith Behnsen et al.
The field of microbiome research has experienced remarkable growth, leading to unprecedented discoveries of the molecular mechanisms that dictate host-microbiota interactions and their crucial roles in human health. In this "chemical biolog...
Metabolic tug-of-war: Microbial metabolism shapes colonization resistance against enteric pathogens [0.03%]
代谢博弈：肠道微生物群代谢对抗病原体的定植抵抗作用
Katerina Jones,Camila Bernardo de Brito,Mariana Xavier Byndloss
Katerina Jones
A widely recognized benefit of gut microbiota is that it provides colonization resistance against enteric pathogens. The gut microbiota and their products can protect the host from invading microbes directly via microbe-pathogen interaction...
Meet the authors: Katerina Jones, Camila Bernardo de Brito, and Mariana Xavier Byndloss [0.03%]
作者见面会：Katerina Jones、Camila Bernardo de Brito和Mariana Xavier Byndloss
Katerina Jones,Camila Bernardo de Brito,Mariana Xavier Byndloss
Katerina Jones
In an interview with Samantha Nelson, a scientific editor of Cell Chemical Biology, the authors of the review entitled "Metabolic tug-o-war: Microbial metabolism shapes colonization resistance against enteric pathogens" share their perspect...
Commensal-derived tryptophan metabolites fortify the skin barrier: Insights from a 50-species gnotobiotic model of human skin microbiome [0.03%]
互利共生派生的色氨酸代谢产物可增强皮肤屏障：来自人类皮肤微生物组50种物种无菌共生模型的新见解
Aayushi Uberoi,Sofía M Murga-Garrido,Preeti Bhanap et al.
Aayushi Uberoi et al.
The epidermal barrier defends the body against dehydration and harmful substances. The commensal microbiota is essential for proper differentiation and repair of the epidermal barrier, an effect mediated by the aryl hydrocarbon receptor (AH...
Meet the authors: Aayushi Uberoi and Elizabeth A. Grice [0.03%]
作者见面会：Aayushi Uberoi和Elizabeth A. Grice
Aayushi Uberoi,Elizabeth A Grice
Aayushi Uberoi
In an interview with Samantha Nelson, a scientific editor of Cell Chemical Biology, the authors of the research article entitled "Commensal-derived tryptophan metabolites fortify the skin barrier: Insights from a 50-species gnotobiotic mode...
A widespread and ancient bacterial machinery assembles cytochrome OmcS nanowires essential for extracellular electron transfer [0.03%]
一种广泛且古老的细菌机器可组装对细胞外电子转移至关重要的OmcS纳米导线
Cong Shen,Aldo I Salazar-Morales,Wonhyeuk Jung et al.
Cong Shen et al.
Microbial extracellular electron transfer (EET) drives various globally important environmental phenomena and has biotechnology applications. Diverse prokaryotes have been proposed to perform EET via surface-displayed "nanowires" composed o...
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation [0.03%]
靶向PCK1和PGC-1α选择性赖氨酸乙酰化的小分子通过增加乳酸氧化产生抗糖尿病作用
Beste Mutlu,Kfir Sharabi,Jee Hyung Sohn et al.
Beste Mutlu et al.
Published Erratum
Cell chemical biology. 2025 Jan 14:S2451-9456(25)00005-4. DOI:10.1016/j.chembiol.2025.01.005 2025