Yevheniia Bushman,Duhita A Mirikar,Andrew W Truman
Yevheniia Bushman
Molecular chaperones like Hsp70s are key players in protein quality control (PQC), capable of eliminating toxic intracellular condensates. In this issue of Cell Chemical Biology, Zhang et al.1 present a computational approach to design nove...
An affinity-based depletion strategy for evaluating the effects of ergothioneine on bacterial physiology [0.03%]
基于亲和力的耗竭策略，用于评估麦角硫因对细菌生理的影响
Anna B Seminara,Stavroula K Hatzios
Anna B Seminara
Ergothioneine (EGT) is a thiol-based antioxidant synthesized by certain fungal and bacterial species that is prevalent in the human diet. Recently, an EGT-specific transporter, EgtUV, was discovered in bacteria that are incapable of EGT bio...
Michael Ebner,Florian Fröhlich,Volker Haucke
Michael Ebner
Lysosomes are the central degradative organelle of mammalian cells and have emerged as major intersections of cellular metabolite flux. Macromolecules derived from dietary and intracellular sources are delivered to the acidic lysosomal lume...
VIPER-TACs leverage viral E3 ligases for disease-specific targeted protein degradation [0.03%]
VIPER-TACs利用病毒E3连接酶实现疾病特异性蛋白质降解
Kyle Mangano,Robert G Guenette,Spencer Hill et al.
Kyle Mangano et al.
In targeted protein degradation (TPD) a protein of interest is degraded by chemically induced proximity to an E3 ubiquitin ligase. One limitation of using TPD therapeutically is that most E3 ligases have broad tissue expression, which can c...
Antibiotic target discovery by integrated phenotypic and activity-based profiling of electrophilic fragments [0.03%]
通过亲电片段的综合表型和基于活性检测来发现抗生素靶标
Yizhen Jin,Sadhan Jana,Mikail E Abbasov et al.
Yizhen Jin et al.
The emergence of antibiotic resistance necessitates the discovery of novel bacterial targets and antimicrobial agents. Here, we present a bacterial target discovery framework that integrates phenotypic screening of cysteine-reactive fragmen...
Tian Qiu,Saara-Anne Azizi,Shubhashree Pani et al.
Tian Qiu et al.
Peroxiredoxins (PRDXs) are a highly conserved family of peroxidases that serve as the primary scavengers of peroxides. Post-translational modifications play crucial roles modulating PRDX activities, tuning the balance between reactive oxyge...
Sara Chiarugi,Francesco Margheriti,Valentina De Lorenzi et al.
Sara Chiarugi et al.
Thiazide and thiazide-like diuretics are among the most efficacious and used drugs for the treatment of hypertension, edema, and major cardiovascular outcomes. Despite more then than six decades of clinical use, the molecular target and mec...
Ligand-induced assembly of antibody variable fragments for the chemical regulation of biological processes [0.03%]
配体诱导的抗体可变片段组装用于生物过程的化学调控
Erik Rihtar,Tina Fink,Tina Lebar et al.
Erik Rihtar et al.
Precise control of biological processes by the application of small molecules can increase the safety and efficiency of therapies. Adverse side effects of small molecule signals and/or immunogenicity of regulatory domains hinder their biome...
An oral tricyclic STING agonist suppresses tumor growth through remodeling of the immune microenvironment [0.03%]
口服三环STING激动剂通过重塑免疫微环境抑制肿瘤生长
Hong-Yi Zhao,Zhongwei Liu,Jinsong Tao et al.
Hong-Yi Zhao et al.
Stimulator of interferon genes (STING) agonists could overcome immunosuppressive microenvironment to improve cancer immunotherapy. However, it is challenging to develop oral STING agonists to achieve systemic immunity. In this study, we dis...
Maysam Mansouri,Martin Fussenegger
Maysam Mansouri
Human body cells and our daily electronic devices both communicate information within their distinct worlds by regulating the flow of electrons across specified membranes. While electronic devices depend on the flow of electrons generated b...