Clionamines stimulate autophagy, inhibit Mycobacterium tuberculosis survival in macrophages, and target Pik1 [0.03%]
Clionamines刺激自噬，抑制巨噬细胞中结核分枝杆菌的生存并针对Pik1蛋白质
Rosanne Persaud,Sheena C Li,Joseph D Chao et al.
Rosanne Persaud et al.
The pathogen Mycobacterium tuberculosis (Mtb) evades the innate immune system by interfering with autophagy and phagosomal maturation in macrophages, and, as a result, small molecule stimulation of autophagy represents a host-directed thera...
Targeting non-canonical pathways as a strategy to modulate the sodium iodide symporter [0.03%]
靶向非常规途径作为调节钠碘同向转运体的一种策略
Martin L Read,Katie Brookes,Caitlin E M Thornton et al.
Martin L Read et al.
The sodium iodide symporter (NIS) functions to transport iodide and is critical for successful radioiodide ablation of cancer cells. Approaches to bolster NIS function and diminish recurrence post-radioiodide therapy are impeded by oncogeni...
Splicing modulators elicit global translational repression by condensate-prone proteins translated from introns [0.03%]
来自内含子的凝聚相倾向蛋白质的翻译诱导了全局翻译抑制
Jagat K Chhipi-Shrestha,Tilman Schneider-Poetsch,Takehiro Suzuki et al.
Jagat K Chhipi-Shrestha et al.
Chemical splicing modulators that bind to the spliceosome have provided an attractive avenue for cancer treatment. Splicing modulators induce accumulation and subsequent translation of a subset of intron-retained mRNAs. However, the biologi...
FADS2-dependent fatty acid desaturation dictates cellular sensitivity to ferroptosis and permissiveness for hepatitis C virus replication [0.03%]
FADS2依赖的脂肪酸去饱和作用决定了细胞对铁死亡的敏感性和允许丙型肝炎病毒复制的程度
Daisuke Yamane,Yuri Hayashi,Moe Matsumoto et al.
Daisuke Yamane et al.
The metabolic oxidative degradation of cellular lipids severely restricts replication of hepatitis C virus (HCV), a leading cause of chronic liver disease, but little is known about the factors regulating this process in infected cells. Her...
CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria [0.03%]
CRAGE-CRISPR促进细菌次级代谢生物合成基因簇的快速激活
Jing Ke,David Robinson,Zong-Yen Wu et al.
Jing Ke et al.
With the advent of genome sequencing and mining technologies, secondary metabolite biosynthetic gene clusters (BGCs) within bacterial genomes are becoming easier to predict. For subsequent BGC characterization, clustered regularly interspac...
Controlled lipid β-oxidation and carnitine biosynthesis by a vitamin D metabolite [0.03%]
由维生素D代谢物控制的脂质β氧化和肉毒碱生物合成
Aileen Mendoza,Yasushi Takemoto,Kevin Tan Cruzado et al.
Aileen Mendoza et al.
Lactone-vitamin D3 is a major metabolite of vitamin D3, a lipophilic vitamin biosynthesized in numerous life forms by sunlight exposure. Although lactone-vitamin D3 was discovered 40 years ago, its biological role remains largely unknown. C...
A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes [0.03%]
一种使用亲电子探针评估E3泛素连接酶组分对新底物细胞活性的策略
Benika J Pinch,Dennis L Buckley,Scott Gleim et al.
Benika J Pinch et al.
While there are hundreds of predicted E3 ligases, characterizing their applications for targeted protein degradation has proved challenging. Here, we report a chemical biology approach to evaluate the ability of modified recombinant E3 liga...
A photoaffinity labeling strategy identified EF1A1 as a binding protein of cyclic dinucleotide 2'3'-cGAMP [0.03%]
基于光亲和标记的策略鉴定EF1A1为环二核苷酸2'3'-cGAMP的结合蛋白
Yingjie Hou,Heng Lu,Jinxin Li et al.
Yingjie Hou et al.
2'3'-cyclic GMP-AMP (2'3'-cGAMP), generated by cyclic GMP-AMP synthase (cGAS) under activation by cytosolic DNA, has a vital role in innate immune response via its receptor protein stimulator of interferon genes (STING) to fight viral infec...
Heterologous characterization of mechercharmycin A biosynthesis reveals alternative insights into post-translational modifications for RiPPs [0.03%]
异源表征Mechercharmycin A生物合成并为RiPPs的翻译后修饰提供了新的见解
Zeng-Fei Pei,Min-Jie Yang,Kai Zhang et al.
Zeng-Fei Pei et al.
Mechercharmycin A (MCM-A) is a marine natural product belonging to a family of polyazole cyclopeptides with remarkable bioactivities and unique structures. Identification, heterologous expression, and genetic characterizations of the MCM bi...
A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells [0.03%]
靶向NSD3的PROTAC在癌细胞中抑制NSD3和c-Myc致癌节点
Chenxi Xu,Fanye Meng,Kwang-Su Park et al.
Chenxi Xu et al.
Nuclear receptor binding SET domain protein 3 (NSD3), a gene located within the 8p11-p12 amplicon frequently detected in human cancers, encodes a chromatin modulator and an attractive onco-target. However, agents that effectively suppress N...