Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors [0.03%]
葡萄糖转运的抑制与化学或遗传破坏线粒体代谢共同作用并抑制TCA循环缺陷肿瘤
Kellen Olszewski,Anthony Barsotti,Xiao-Jiang Feng et al.
Kellen Olszewski et al.
Efforts to target glucose metabolism in cancer have been limited by the poor potency and specificity of existing anti-glycolytic agents and a poor understanding of the glucose dependence of cancer subtypes in vivo. Here, we present an exten...
Junghyun L Suh,Daniel Bsteh,Bryce Hart et al.
Junghyun L Suh et al.
Canonical targeting of Polycomb repressive complex 1 (PRC1) to repress developmental genes is mediated by cell-type-specific, paralogous chromobox (CBX) proteins (CBX2, 4, 6, 7, and 8). Based on their central role in silencing and their dys...
A non-reactive natural product precursor of the duocarmycin family has potent and selective antimalarial activity [0.03%]
杜奧卡馬ycin家族的一種非反應性天然產物前體具有強大而選擇性的抗瘧疾作用
Arne Alder,Nicole S Struck,Min Xu et al.
Arne Alder et al.
We identify a selective nanomolar inhibitor of blood-stage malarial proliferation from a screen of microbial natural product extracts. The responsible compound, PDE-I2, is a precursor of the anticancer duocarmycin family that preserves the ...
Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth [0.03%]
雷帕霉素作用于STAT3并影响c-Myc以抑制肿瘤生长
Le Sun,Yu Yan,Heng Lv et al.
Le Sun et al.
Rapamycin is widely recognized as an inhibitor of mTOR, and has been approved for clinical use as an immunosuppressant. Its potencies in anti-cancer, anti-aging, and neurodegenerative diseases are emergingly established. The exploration of ...
Protein engineering of a stable and potent anti-inflammatory IL-37-Fc fusion with enhanced therapeutic potential [0.03%]
稳定的高抗炎活性IL-37-Fc融合蛋白工程改造及其增强的治疗潜力
Alexander Bujotzek,Georg Tiefenthaler,Laurent Lariviere et al.
Alexander Bujotzek et al.
Harnessing the immunomodulatory activity of cytokines is a focus of therapies targeting inflammatory disease. The interleukin (IL)-1 superfamily contains pro-inflammatory and anti-inflammatory members that help orchestrate the immune respon...
A transcriptional relationship with a natural product disrupts mitochondrial biogenesis [0.03%]
与天然产物的转录关系扰乱了线粒体生物发生
Aaron T Wright
Aaron T Wright
A limonoid natural product disrupts mitochondrial biogenesis and overcomes resistance. In this issue of Cell Chemical Biology, Cho et al. describe an anti-melanoma strategy in which a transcriptional target gene enables the anti-proliferati...
Qiang Liu,Jean C Y Wang,Stephanie Z Xie
Qiang Liu
Sumoylation is a reversible post-translational modification implicated in cancer. In this issue of Cell Chemical Biology, Benoit et al. describe an inhibitor of sumoylation that results in anti-proliferative effects in cancer stem cell mode...
Mishtu Dey
Mishtu Dey
Screening compound libraries for H2O2-mediated cancer therapeutics using a peroxiredoxin-based sensor [0.03%]
使用过氧化物酶传感器筛选H2O2介导的癌症治疗的化合物库
Yining Hao,Troy F Langford,Sun Jin Moon et al.
Yining Hao et al.
Compounds that modulate H2O2 reaction networks have applications as targeted cancer therapeutics, as a subset of cancers exhibit sensitivity to this redox signal. Previous studies to identify therapeutics that induce oxidants have relied up...
An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity [0.03%]
基于抗体的邻近标记图揭示了SARS-CoV-2抑制抗病毒免疫的机制
Yuehui Zhang,Limin Shang,Jing Zhang et al.
Yuehui Zhang et al.
The global epidemic caused by the coronavirus severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has resulted in the infection of over 200 million people. To extend the knowledge of interactions between SARS-CoV-2 and humans, we s...