An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance [0.03%]
IRS2反义转录本通过促进肝脏脂质积累参与胰岛素抵抗病理进程
Maya Matsushita,Motoharu Awazawa,Naoki Kobayashi et al.
Maya Matsushita et al.
During insulin resistance, lipid uptake by the liver is promoted by peroxisome proliferator-activated protein (PPAR) γ upregulation, leading to hepatic steatosis. Insulin, however, does not directly regulate adipogenic gene expression in l...
Morphological profiling by means of the Cell Painting assay enables identification of tubulin-targeting compounds [0.03%]
基于细胞图像描绘技术的形态谱分析能够鉴定微管靶向化合物
Mohammad Akbarzadeh,Ilka Deipenwisch,Beate Schoelermann et al.
Mohammad Akbarzadeh et al.
In phenotypic compound discovery, conclusive identification of cellular targets and mode of action are often impaired by off-target binding. In particular, microtubules are frequently targeted in cellular assays. However, in vitro tubulin b...
Chemoselective restoration of para-azido-phenylalanine at multiple sites in proteins [0.03%]
蛋白质中多个位点选择性恢复对氨基苯丙氨酸
Pol Arranz-Gibert,Koen Vanderschuren,Adrian Haimovich et al.
Pol Arranz-Gibert et al.
The site-specific incorporation of nonstandard amino acids (nsAAs) during translation has expanded the chemistry and function of proteins. The nsAA para-azido-phenylalanine (pAzF) encodes a biorthogonal chemical moiety that facilitates "cli...
Differential effects of modified batrachotoxins on voltage-gated sodium channel fast and slow inactivation [0.03%]
修饰蛙毒素对电压门控钠离子通道快相和慢相失活的不同影响
Tim M G MacKenzie,Fayal Abderemane-Ali,Catherine E Garrison et al.
Tim M G MacKenzie et al.
Voltage-gated sodium channels (NaVs) are targets for a number of acute poisons. Many of these agents act as allosteric modulators of channel activity and serve as powerful chemical tools for understanding channel function. Herein, we detail...
Michael Morgan,Tatsuya Ikenoue,Hiroaki Suga et al.
Michael Morgan et al.
The Spt-Ada-Gcn5 acetyltransferase (SAGA) transcriptional coactivator contains a four-protein subcomplex called the deubiquitinating enzyme (DUB) module that removes ubiquitin from histone H2B-K120. The human DUB module contains the catalyt...
3D two-photon brain imaging reveals dihydroartemisinin exerts antiepileptic effects by modulating iron homeostasis [0.03%]
三维双光子脑成像揭示了二氢青蒿素通过调节铁稳态发挥抗癫痫作用
Chenwen Shao,Yani Liu,Zhangpeng Chen et al.
Chenwen Shao et al.
Imbalanced iron homeostasis plays a crucial role in neurological diseases, yet direct imaging evidence revealing the distribution of active ferrous iron (Fe2+) in the living brain remains scarce. Here, we present a near-infrared excited two...
Identification of small molecules that strongly inhibit bacterial quorum sensing using a high-throughput lipid vesicle lysis assay [0.03%]
基于巨量筛检脂质体崩解的细菌群体感应强抑制小分子化合物之鉴定研究
Thomas J Polaske,Curran G Gahan,Kayleigh E Nyffeler et al.
Thomas J Polaske et al.
Strategies to both monitor and block bacterial quorum sensing (QS), and thus associated infections, are of significant interest. We developed a straightforward assay to monitor biosurfactants and lytic agents produced by bacteria under the ...
Rebekah P Dyer,Gregory A Weiss
Rebekah P Dyer
Proteases cut with enviable precision and regulate diverse molecular events in biology. Such qualities drive a seemingly inexhaustible appetite for proteases with new activities and capabilities. Comprising 25% of the total industrial enzym...
Targeting ribosomal G-quadruplexes with naphthalene-diimides as RNA polymerase I inhibitors for colorectal cancer treatment [0.03%]
靶向核糖体G-四链体：萘二酰亚胺类RNA聚合酶I抑制剂在结直肠癌治疗中的应用
Victoria Sanchez-Martin,David A Schneider,Matilde Ortiz-Gonzalez et al.
Victoria Sanchez-Martin et al.
Published Erratum
Cell chemical biology. 2021 Dec 16;28(12):1807. DOI:10.1016/j.chembiol.2021.12.007 2021
Early DNA damage detection and cellular autophagy as drivers of stress-adaptive H2S production: A paradox resolved [0.03%]
早期DNA损伤检测和细胞自噬驱动应激适应性H2S产生：一个悖论的解决
Christopher Hine,Derek A Wainwright,Justin D Lathia
Christopher Hine
Appropriately responding and adapting to genotoxic, oxidative, and metabolic stress is essential for survival and is at the heart of maintaining homeostasis. In this issue of Cell Chemical Biology, Jiang et al. (2021) describe an autophagy-...