Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer [0.03%]
去势抵抗性前列腺癌蛋白稳态网络的选择性脆弱性
Arielle Shkedi,Isabelle R Taylor,Frank Echtenkamp et al.
Arielle Shkedi et al.
Castration-resistant prostate cancer (CRPC) is associated with an increased reliance on heat shock protein 70 (HSP70), but it is not clear what other protein homeostasis (proteostasis) factors might be involved. To address this question, we...
Multiple PDE3A modulators act as molecular glues promoting PDE3A-SLFN12 interaction and induce SLFN12 dephosphorylation and cell death [0.03%]
多种PDE3A调制剂作为分子胶促进PDE3A-SLFN12相互作用并诱导SLFN12去磷酸化和细胞死亡
Bo Yan,Zhangcheng Ding,Wenbin Zhang et al.
Bo Yan et al.
The canonical function of phosphodiesterase 3A (PDE3A) is to hydrolyze the phosphodiester bonds in second messenger molecules, such as cyclic AMP (cAMP) and cyclic guanosine monophosphate (cGMP). Recently, a phosphodiesterase-activity-indep...
Identifying and antagonizing the interactions between layilin and glycosylated collagens [0.03%]
鉴定并拮抗layilin与糖基化胶原之间的相互作用
Jeff E Glasgow,James R Byrnes,Susannah D Barbee et al.
Jeff E Glasgow et al.
Layilin is a small type I transmembrane receptor thought to bridge extracellular ligands with the cytoskeleton through its intracellular interactions with the scaffolding protein talin. Recent bulk- and single-cell RNA sequencing experiment...
Motif-dependent immune co-receptor interactome profiling by photoaffinity chemical proteomics [0.03%]
基于光亲和化学蛋白质组学的免疫共受体相互作用组剖析
Xiong Chen,Shanping Ji,Zheyi Liu et al.
Xiong Chen et al.
Identification of the tyrosine phosphorylation (pY)-dependent interactome of immune co-receptors is crucial for understanding signal pathways involved in immunotherapy. However, identifying the motif-specific interactome for each pY commonl...
Kamakshi Sishtla,Nathan Lambert-Cheatham,Bit Lee et al.
Kamakshi Sishtla et al.
Activity of the heme synthesis enzyme ferrochelatase (FECH) is implicated in multiple diseases. In particular, it is a mediator of neovascularization in the eye and thus an appealing therapeutic target for preventing blindness. However, no ...
Ligand-induced interactions between butyrophilin 2A1 and 3A1 internal domains in the HMBPP receptor complex [0.03%]
HMBPP受体复合物中但又素2A1和3A1内域的配体诱导相互作用
Chia-Hung Christine Hsiao,Khiem Nguyen,Yiming Jin et al.
Chia-Hung Christine Hsiao et al.
The ligand-bound (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP) receptor (BTN3A1 and BTN2A1) is detectable by the T cell receptor (TCR) of Vγ9Vδ2 T cells. Although BTN3A1 binds to phosphoantigens (pAgs), the mechanisms resulting in...
Joan Ritho,Scott J Dixon
Joan Ritho
Ferroptosis is an iron-dependent form of cell death implicated in cancer and neurodegenerative diseases. In this issue of Cell Chemical Biology, Shao et al. (2022) and Wang et al. (2022) describe imaging techniques to monitor ferrous iron l...
Mishtu Dey
Mishtu Dey
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses [0.03%]
一种临床批准药物acriflavine可抑制SARS-CoV-2及其他贝塔冠状病毒
Valeria Napolitano,Agnieszka Dabrowska,Kenji Schorpp et al.
Valeria Napolitano et al.
The COVID-19 pandemic caused by SARS-CoV-2 has been socially and economically devastating. Despite an unprecedented research effort and available vaccines, effective therapeutics are still missing to limit severe disease and mortality. Usin...
Increased energy demand from anabolic-catabolic processes drives β-lactam antibiotic lethality [0.03%]
合成与分解代谢过程的能耗增加驱动β-内酰胺抗生素杀菌作用
Michael A Lobritz,Ian W Andrews,Dana Braff et al.
Michael A Lobritz et al.
β-Lactam antibiotics disrupt the assembly of peptidoglycan (PG) within the bacterial cell wall by inhibiting the enzymatic activity of penicillin-binding proteins (PBPs). It was recently shown that β-lactam treatment initializes a futile ...