Integrating complex host-pathogen immune environments into S. aureus vaccine studies [0.03%]
复杂宿主病原免疫环境在金黄色葡萄球菌疫苗研究中的应用整合
Chih-Ming Tsai,Irshad A Hajam,J R Caldera et al.
Chih-Ming Tsai et al.
Staphylococcus aureus (SA) is a leading cause of bacterial infection and antibiotic resistance globally. Therefore, development of an effective vaccine has been a major goal of the SA field for the past decades. With the wealth of understan...
Jason E Gestwicki
Jason E Gestwicki
The molecular chaperone DnaK, is an attractive drug target for treating mycobacterial infections. In this issue, Hosfelt, Richards, and colleagues applied a high-throughput screen and discovered inhibitors that disrupt cofactor-mediated act...
Chemical strategies to understand and manipulate host-pathogen interactions [0.03%]
用于理解和操纵宿主-病原体相互作用的化学策略
Bridget K Wagner,Mishtu Dey
Bridget K Wagner
Integrated genomics and chemical biology herald an era of sophisticated antibacterial discovery, from defining essential genes to target elucidation [0.03%]
整合基因组学和化学生物学宣告了一个抗菌发现的时代，从定义必需基因到靶点确证
Thulasi Warrier,Keith P Romano,Anne E Clatworthy et al.
Thulasi Warrier et al.
The golden age of antibiotic discovery in the 1940s-1960s saw the development and deployment of many different classes of antibiotics, revolutionizing the field of medicine. Since that time, our ability to discover antibiotics of novel stru...
Control of host PTMs by intracellular bacteria: An opportunity toward novel anti-infective agents [0.03%]
宿主PTM的胞内细菌调控：开发新型抗菌剂的机会
Virginie Stévenin,Jacques Neefjes
Virginie Stévenin
Intracellular bacteria have developed a multitude of mechanisms to influence the post-translational modifications (PTMs) of host proteins to pathogen advantages. The recent explosion of insights into the diversity and sophistication of host...
Shamshad Alam,Boyko S Atanassov
Shamshad Alam
In this issue of Cell Chemical Biology, Morgan et al. (2021) show that cyclic peptides can be potent and highly specific inhibitors for deubiquitinating enzymes. This study identifies the first selective inhibitors of the cancer-associated ...
Umut Ozcan
Umut Ozcan
Accumulation of fat in the liver predisposes affected individuals to a variety of diseases, yet the molecular mechanisms leading to steatosis still remain elusive. Matsushita et al. (2022) propose a novel mechanism that interconnects insuli...
Lockdown, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion [0.03%]
Lockdown是一种选择性的小分子PPM1F整合素磷酸酶抑制剂，可阻断癌细胞侵袭
Tanja M Grimm,Marleen Herbinger,Lena Krüger et al.
Tanja M Grimm et al.
Phosphatase PPM1F is a regulator of cell adhesion by fine-tuning integrin activity and actin cytoskeleton structures. Elevated expression of this enzyme in human tumors is associated with high invasiveness, enhanced metastasis, and poor pro...
Cellular signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation in cancer cells [0.03%]
细胞信号通过NOX2-SHP-2轴诱导癌细胞反向糖酵解的作用机制研究
Rukang Zhang,Dong Chen,Hao Fan et al.
Rukang Zhang et al.
Environmental stresses, including hypoxia or detachment for anchorage independence, or attenuation of mitochondrial respiration through inhibition of electron transport chain induce reductive carboxylation in cells with an enhanced fraction...
Jaime N Coronado,Phuoc Ngo,Eric V Anslyn et al.
Jaime N Coronado et al.
A critical step in repurposing the cellular translation machinery for the synthesis of polymeric products is the acylation of transfer RNA (tRNA) with unnatural monomers. Toward this goal, flexizymes, ribozymes capable of aminoacylation, ha...