Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling [0.03%]
来那度胺通过激活Notch信号通路重新激活PD-1免疫疗法而不依赖于CD28共刺激分子
Chen-Lu Geng,Jun-Yi Chen,Tian-Yu Song et al.
Chen-Lu Geng et al.
Programmed cell death protein 1 (PD-1) checkpoint blockade therapy requires the CD28 co-stimulatory receptor for CD8+ T cell expansion and cytotoxicity. However, CD28 expression is frequently lost in exhausted T cells and during immune sene...
Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses [0.03%]
鉴定增强先天性免疫信号的小分子诱导剂作为广谱抗病毒活性物质以应对新发病毒
Ghizlane Maarifi,Marie-France Martin,Abderezak Zebboudj et al.
Ghizlane Maarifi et al.
The increasingly frequent outbreaks of pathogenic viruses have underlined the urgent need to improve our arsenal of antivirals that can be deployed for future pandemics. Innate immunity is a powerful first line of defense against pathogens,...
Visualization of the dynamic interaction between nucleosomal histone H3K9 tri-methylation and HP1α chromodomain in living cells [0.03%]
活细胞中组蛋白H3K9三甲基化核小体与HP1α阅读结构域动态结合的可视化研究
Kazuki Sasaki,Michihiro Suzuki,Takeshi Sonoda et al.
Kazuki Sasaki et al.
Histone lysine methylation is an epigenetic mark that can control gene expression. In particular, H3K9me3 contributes to transcriptional repression by regulating chromatin structure. Successful mitotic progression requires correct timing of...
Clearing the air: Uniquely engaging furin as an approach to cystic fibrosis therapy [0.03%]
拨开迷雾：激活furin蛋白作为治疗囊性纤维化的独特策略
Digant Nayak,Elizabeth V Wasmuth,Shaun K Olsen
Digant Nayak
In this issue of Cell Chemical Biology, Douglas et al. describe a potent, specific, and cell-permeable furin inhibitor that interacts with a cryptic binding site to rescue hallmarks of cystic fibrosis in human ex vivo models. BOS-318 holds ...
A complex puzzle: Regulation of SLFN12 RNase activity by phosphorylation [0.03%]
一个复杂的谜题：SLFN12 RNase活性的磷酸化调控
Heidi Greulich
Heidi Greulich
PDE3A-SLFN12 complex formation activates the SLFN12 RNase, but the biochemical details of RNase activation remain mysterious. In this issue of Cell Chemical Biology, Yan and colleagues report that two phosphoserines on SLFN12 are dephosphor...
Evidence that HDAC7 acts as an epigenetic "reader" of AR acetylation through NCoR-HDAC3 dissociation [0.03%]
HDAC7充当表观遗传“阅读者”通过NCoR-HDAC3解离作用解读AR乙酰化现象的证据
Yuchen Zhang,Rafael Andrade,Anthony A Hanna et al.
Yuchen Zhang et al.
Histone deacetylase (HDAC) proteins are epigenetic regulators that govern a wide variety of cellular events. With a role in cancer formation, HDAC inhibitors have emerged as anti-cancer therapeutics. Among the eleven metal-dependent class I...
Sana Khan Khilji,Felix Goerdeler,Kristin Frensemeier et al.
Sana Khan Khilji et al.
The development of antibodies that target specific glycan structures on cancer cells or human pathogens poses a significant challenge due to the immense complexity of naturally occurring glycans. Automated glycan assembly enables the produc...
Acylation probing of "generic" RNA libraries reveals critical influence of loop constraints on reactivity [0.03%]
酰化探针研究揭示了“通用”RNA文库中的发卡结构对反应活性的制约作用
Lu Xiao,Linglan Fang,Eric T Kool
Lu Xiao
The reactivity of RNA 2'-OH acylation is broadly useful both in probing structure and in preparing conjugates. To date, this reactivity has been analyzed in limited sets of biological RNA sequences, leaving open questions of how reactivity ...
Visualizing Staphylococcus aureus pathogenic membrane modification within the host infection environment by multimodal imaging mass spectrometry [0.03%]
利用多模成像质谱技术可视化宿主感染环境中金黄色葡萄球菌病原膜修饰状况
William J Perry,Caroline M Grunenwald,Raf Van de Plas et al.
William J Perry et al.
Bacterial pathogens have evolved virulence factors to colonize, replicate, and disseminate within the vertebrate host. Although there is an expanding body of literature describing how bacterial pathogens regulate their virulence repertoire ...
A direct high-throughput protein quantification strategy facilitates discovery and characterization of a celastrol-derived BRD4 degrader [0.03%]
一种直接的高通量蛋白质定量策略促进了基于取藤苷的BRD4降解剂的发现与鉴定
N Connor Payne,Semer Maksoud,Bakhos A Tannous et al.
N Connor Payne et al.
We describe a generalizable time-resolved Förster resonance energy transfer (TR-FRET)-based platform to profile the cellular action of heterobifunctional degraders (or proteolysis-targeting chimeras [PROTACs]) that is capable of both accur...