Leslie Magtanong,Grace D Mueller,Kevin J Williams et al.
Leslie Magtanong et al.
Published Erratum
Cell chemical biology. 2022 Oct 20;29(10):1568. DOI:10.1016/j.chembiol.2022.08.008 2022
A propeptide-based biosensor for the selective detection of Vibrio cholerae using an environment-sensitive fluorophore [0.03%]
一种基于信号肽的生物传感器用于选择性检测霍乱弧菌及其环境敏感型荧光报告基的研究
Alicia A DeColli,Isabel M Koolik,Anna B Seminara et al.
Alicia A DeColli et al.
Proteases are attractive targets for infectious disease diagnostics. Peptide-based sensors that are cleaved by pathogen proteases can provide a rapid readout of infection. However, identifying peptide substrates specific to a targeted patho...
Hannah Y Collins,Ben Emery
Hannah Y Collins
In this issue, Häberlein et al. demonstrate a role for GPR17 in regulating zebrafish oligodendrocyte differentiation. Zebrafish expressing a humanized GPR17 respond to modulators, which are inactive against the endogenous zebrafish recepto...
Varun Jayeshkumar Shah,Ivan Đikić
Varun Jayeshkumar Shah
Many factors influence the efficiency of targeted protein degradation induced by proteolysis targeting chimeras (PROTACs). In this issue of Cell Chemical Biology,Simpson et al. (2022) highlight the impact of subcellular localization. Their ...
Acute pharmacological degradation of ERK5 does not inhibit cellular immune response or proliferation [0.03%]
ERK5的急性药理退化不影响细胞免疫反应或增殖
Inchul You,Katherine A Donovan,Noah M Krupnick et al.
Inchul You et al.
Recent interest in the role that extracellular signal-regulated kinase 5 (ERK5) plays in various diseases, particularly cancer and inflammation, has grown. Phenotypes observed from genetic knockdown or deletion of ERK5 suggested that target...
Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization [0.03%]
共价抑制端粒酶逆转录酶的NU-1敏化免疫辐射作用
Yue Liu,Rick C Betori,Joanna Pagacz et al.
Yue Liu et al.
Beyond synthesizing telomere repeats, the telomerase reverse transcriptase (TERT) also serves multiple other roles supporting cancer growth. Blocking telomerase to drive telomere erosion appears impractical, but TERT's non-canonical activit...
Dimerization of β2-adrenergic receptor is responsible for the constitutive activity subjected to inverse agonism [0.03%]
β2-肾上腺素能受体二聚化导致固有活性并接受反向激动作用
Yonghoon Kwon,Do-Hyeon Kim,Min Gyu Jeong et al.
Yonghoon Kwon et al.
Dimerization of beta 2-adrenergic receptor (β2-AR) has been observed across various physiologies. However, the function of dimeric β2-AR is still elusive. Here, we revealed that dimerization of β2-AR is responsible for the constitutive a...
Humanized zebrafish as a tractable tool for in vivo evaluation of pro-myelinating drugs [0.03%]
人源化斑马鱼作为评估促进少突胶质细胞成熟的药物的体内工具
Felix Häberlein,Enrico Mingardo,Nicole Merten et al.
Felix Häberlein et al.
Therapies that promote neuroprotection and axonal survival by enhancing myelin regeneration are an unmet need to prevent disability progression in multiple sclerosis. Numerous potentially beneficial compounds have originated from phenotypic...
Cut it out! A CRISPR-Cas9 screen identifies host regulators of the Plasmodium liver stage [0.03%]
crispr-cas9筛选鉴定出宿主转录调控因子影响肝脏疟疾原虫发育
Michael E Chirgwin,Erin A Schroeder,Emily R Derbyshire
Michael E Chirgwin
In this issue of Cell Chemical Biology, Vijayan and colleagues identify host factors integral for Plasmodium liver-stage infection using a whole-genome CRISPR-Cas9 knockout screen. Their efforts reveal that liver-stage parasites redistribut...
Hyemin Lee,Boyi Gan
Hyemin Lee
ACSL4 is generally considered to be universally required for ferroptosis, a form of cell death induced by phospholipid peroxidation. In this issue of Cell Chemical Biology, Magtanong et al. (2022) report the surprising finding that ACSL4 is...