SIM imaging resolves endocytosis of SARS-CoV-2 spike RBD in living cells [0.03%]
活细胞内SARS-CoV-2刺突RBD胞吞作用的SIM成像解析
Lu Miao,Chunyu Yan,Yingzhu Chen et al.
Lu Miao et al.
It is urgent to understand the infection mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for the prevention and treatment of COVID-19. The infection of SARS-CoV-2 starts when the receptor-binding domain (RBD) of vi...
NAT8L mRNA oxidation is linked to neurodegeneration in multiple sclerosis [0.03%]
NAT8L mRNA氧化与多发性硬化神经退行性疾病相关
Prakash Kharel,Naveen Kumar Singhal,Thulasi Mahendran et al.
Prakash Kharel et al.
RNA oxidation has been implicated in neurodegeneration, but the underlying mechanism for such effects is unclear. Extensive RNA oxidation occurs within the neurons in multiple sclerosis (MS) brains. Here, we identified selectively oxidized ...
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy [0.03%]
一种用于癌症免疫治疗的选择性IKZF2“胶水”降解剂的发现与表征
Simone Bonazzi,Eva d&#x;Hennezel,Rohan E J Beckwith et al.
Simone Bonazzi et al.
Malignant tumors can evade destruction by the immune system by attracting immune-suppressive regulatory T cells (Treg) cells. The IKZF2 (Helios) transcription factor plays a crucial role in maintaining function and stability of Treg cells, ...
Chemical inhibition of mitochondrial fission via targeting the DRP1-receptor interaction [0.03%]
通过靶向DRP1受体相互作用抑制线粒体分裂的化学方法
Jun Yang,Peihao Chen,Yu Cao et al.
Jun Yang et al.
Mitochondrial fission is critical for mitochondrial dynamics and homeostasis. The dynamin superfamily GTPase DRP1 is recruited by three functionally redundant receptors, MFF, MiD49, and MiD51, to mitochondria to drive fission. Here, we expl...
N6-methyladenosine modification in 18S rRNA promotes tumorigenesis and chemoresistance via HSF4b/HSP90B1/mutant p53 axis [0.03%]
18S rRNA N6-甲基腺苷修饰通过HSF4b/HSP90B1/突变型p53轴促进肿瘤发生和化疗耐药性
Binbin Chen,Ying Huang,Shuiqing He et al.
Binbin Chen et al.
Aberrant N6-methyladenosine (m6A) modification on mRNA is correlated with cancer progression. However, the role of m6A on ribosomal RNA (rRNA) in cancer remains poorly understood. Our current study reveals that METTL5/TRMT112 and their medi...
Making bubbles: Targeting VPS41 induces vacuolization and methuosis [0.03%]
制造泡球：靶向VPS41诱导液泡化和methuosis
Nienke Julia Dekker,Luca Laraia
Nienke Julia Dekker
In this issue of Cell Chemical Biology, Liu et al. describe the natural product DMBP as the first tool compound for VPS41. Treatment with DMBP induced vacuolization and methuosis and inhibited autophagic flux in lung and pancreatic cancer c...
Ternary complex dissociation kinetics contribute to mutant-selective EGFR degradation [0.03%]
三级复合物解离动力学有利于选择性降解突变型EGFR蛋白
Scott C Rosenberg,Frances Shanahan,Sayumi Yamazoe et al.
Scott C Rosenberg et al.
Targeted degradation of proteins by chimeric heterobifunctional degraders has emerged as a major drug discovery paradigm. Despite the increased interest in this approach, the criteria dictating target protein degradation by a degrader remai...
Selective and brain-penetrant lanosterol synthase inhibitors target glioma stem-like cells by inducing 24(S),25-epoxycholesterol production [0.03%]
选择性且可穿越血脑屏障的羊毛固醇合酶抑制剂通过诱导24(S),25-环氧胆固醇产生靶向胶质瘤干细胞类细胞
Thu P Nguyen,Wentian Wang,Alex C Sternisha et al.
Thu P Nguyen et al.
Glioblastoma (GBM) is an aggressive adult brain cancer with few treatment options due in part to the challenges of identifying brain-penetrant drugs. Here, we investigated the mechanism of MM0299, a tetracyclic dicarboximide with anti-gliob...
Piperlongumine conjugates induce targeted protein degradation [0.03%]
Piperlongumine conjugates 诱导靶向蛋白降解
Jing Pei,Yufeng Xiao,Xingui Liu et al.
Jing Pei et al.
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that degrade target proteins through recruiting E3 ligases. However, their application is limited in part because few E3 ligases can be recruited by known E3 ligase ligands...
An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation [0.03%]
一种靶向蛋白质去磷酸化的亲和定向蛋白酪氨酸磷酸酶系统Affinity-directed Phosphatase (AdPhosphatase)
Luke M Simpson,Luke J Fulcher,Gajanan Sathe et al.
Luke M Simpson et al.
Reversible protein phosphorylation, catalyzed by protein kinases and phosphatases, is a fundamental process that controls protein function and intracellular signaling. Failure of phospho-control accounts for many human diseases. While a kin...