Spatiotemporally resolved GPCR interactome uncovers unique mediators of receptor agonism [0.03%]
时空解析G蛋白偶联受体互作组以发现独特的受体激活调节因子
Maria M Shchepinova,Rachel Richardson,Jack W Houghton et al.
Maria M Shchepinova et al.
Cellular signaling by membrane G protein-coupled receptors (GPCRs) is governed by a complex and diverse array of mechanisms. The dynamics of a GPCR interactome, as it evolves over time and space in response to an agonist, provide a unique p...
Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases [0.03%]
工程化ERα降解剂及其利用不同效ector连接酶最大化治疗效果的多效性泛素连接酶配体
Anna Shemorry,Willem den Besten,Melinda M Mulvihill et al.
Anna Shemorry et al.
Proximity-inducing compounds that modulate target protein homeostasis represent an emerging therapeutic strategy. While the inherent complexity of these bifunctional compounds presents certain challenges, their unique composition offers opp...
Decoding the minute-by-minute GPCR interactome unveils hormone signaling gatekeepers [0.03%]
揭秘GPCR分钟尺度的相互作用组网络，发现激素信号通路的关键节点
Wenqing Shui
Wenqing Shui
In this issue of Cell Chemical Biology, Shchepinova et al.1 map the luteinizing hormone receptor (LHR) interactome with sub-minute precision. They identify novel regulators, such as RAP2B, which influences cAMP signaling and endosomal traff...
Mitchel L Tepe,Huiqing Zhou
Mitchel L Tepe
In an interview with Dr. Samantha Nelson, a scientific editor of Cell Chemical Biology, the authors of the Resource article entitled "MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA" share the...
Meet the authors: Xing Zhang, Kyong Fam, Tingting Dai, and Howard Hang [0.03%]
作者见面会：张兴、Fam Kyong、戴婷婷和Howard Hang
Xing Zhang,Kyong Fam,Tingting Dai et al.
Xing Zhang et al.
In an interview with Dr. Mishtu Dey, the editor-in-chief of Cell Chemical Biology, the authors of the Review article entitled "Microbiota mechanisms in cancer progression and therapy" share their perspectives on their field and lives as sci...
Meet the Cell Chemical Biology author and newest advisory board member: Marcus Conrad [0.03%]
遇见《细胞化学生物学》作者及最新的编委会成员：Marcus Conrad教授
Marcus Conrad
Marcus Conrad
In an interview with Dr. Mishtu Dey, the editor-in-chief of Cell Chemical Biology, Prof. Marcus Conrad, a new advisory board member and lead author of the paper entitled "N-acetyl-L-cysteine averts ferroptosis by fostering glutathione perox...
MapID-based quantitative mapping of chemical modifications and expression of human transfer RNA [0.03%]
基于MapID的人类tRNA化学修饰和表达的定量映射
Mitchel L Tepe,Yitan Chen,Allison Carso et al.
Mitchel L Tepe et al.
Detection and quantification of tRNA chemical modifications are critical for understanding their regulatory functions in biology and diseases. However, tRNA-seq-based methods for modification mapping encountered challenges both experimental...
N-acetyl-l-cysteine averts ferroptosis by fostering glutathione peroxidase 4 [0.03%]
N-乙酰半胱氨酸通过促进谷氧还蛋白4来防止铁死亡发生
Jiashuo Zheng,Weijia Zhang,Junya Ito et al.
Jiashuo Zheng et al.
N-acetyl-l-cysteine (NAC) is a medication and a widely used antioxidant in cell death research. Despite its somewhat obscure mechanism of action, its role in inhibiting ferroptosis is gaining increasing recognition. In this study, we demons...
Emma Guilbaud,Flavie Naulin,Lydia Meziani et al.
Emma Guilbaud et al.
External beam radiation therapy (RT) is a cornerstone of modern cancer management, being utilized in both curative and palliative settings due to its safety, efficacy, and widespread availability. A primary biological effect of RT is DNA da...
Genetically encoded tool for manipulation of ΔΨm identifies its role as the driver of ISR induced by ATP synthase dysfunction [0.03%]
基因编码工具调控ΔΨm鉴定了其作为ATP合成酶功能障碍诱导的ISR驱动因子的作用
Mangyu Choe,Alex E Ekvik,Gretchen Stalnaker et al.
Mangyu Choe et al.
Mitochondrial membrane potential (ΔΨm) is one of the key parameters controlling cellular bioenergetics. Investigation of the role of ΔΨm in live cells is complicated by a lack of tools for its direct manipulation without off-target effe...