Sabotaging the breaks: FSEN1 expands the toolbox of FSP1 inhibitors [0.03%]
破坏制动装置：FSEN1扩展了FSP1抑制剂的工具箱
Thamara Nishida Xavier da Silva,José Pedro Friedmann Angeli
Thamara Nishida Xavier da Silva
The report of heightened lipid peroxidation has shone a spotlight on vulnerabilities within challenging cancers. In this context, FSP1 emerges as a pivotal regulator, actively countering the destructive effects of lipid peroxidation. In a g...
Un-FASN-ing cancer's seat belt: Linking lipid metabolism and antigen presentation [0.03%]
解开癌症的安全带：脂质代谢与抗原呈递之间的联系
Zachary Corey,Elyse Schechter,Raphael A Nemenoff
Zachary Corey
MHC-II expression on cancer cells is associated with improved treatment outcome. In this issue, Huang et al.1 report a panel of small molecules that selectively upregulate MHC-II on cancer cells through suppression of fatty acid synthase (F...
Zixue Jin,Brendan Lee
Zixue Jin
Individuals with type 1 diabetes (T1D) have an increased risk of osteoporosis and fracture. In this issue of Cell Chemical Biology, Ji et al.1 show that impaired glucose metabolism in the bone-forming osteoblast drives diabetic osteoporosis...
Metabolic modulation of mitochondrial mass during CD4+ T cell activation [0.03%]
活化期间代谢调节线粒体质量以影响CD4+t细胞的功能及分化方向
Kiran Kurmi,Dan Liang,Robert van de Ven et al.
Kiran Kurmi et al.
Mitochondrial biogenesis initiates within hours of T cell receptor (TCR) engagement and is critical for T cell activation, function, and survival; yet, how metabolic programs support mitochondrial biogenesis during TCR signaling is not full...
Chemoproteomic strategy identified p120-catenin glutathionylation regulates E-cadherin degradation and cell migration [0.03%]
化学蛋白质组学策略识别出p120-钙黏着蛋白谷胱甘肽化调控E-钙黏着蛋白降解和细胞迁移
Dhanushika S K Kukulage,Maheeshi Yapa Abeywardana,Nadee N J Matarage Don et al.
Dhanushika S K Kukulage et al.
Identification of cysteines with high oxidation susceptibility is important for understanding redox-mediated biological processes. In this report, we report a chemical proteomic strategy that finds cysteines with high susceptibility to S-gl...
Isara Laothamatas,Emil Sjulstok Rasmussen,Carla B Green et al.
Isara Laothamatas et al.
Circadian rhythms are endogenous periodic biological processes that occur on a daily timescale. These rhythms are generated by a transcriptional/translational feedback loop that consists of the CLOCK-BMAL1 heterodimeric transcriptional acti...
Graham P Lobel,Yanqing Jiang,M Celeste Simon
Graham P Lobel
Over the last two decades, the rapidly expanding field of tumor metabolism has enhanced our knowledge of the impact of nutrient availability on metabolic reprogramming in cancer. Apart from established roles in cancer cells themselves, vari...
Screening in serum-derived medium reveals differential response to compounds targeting metabolism [0.03%]
基于血清衍生培养基的筛选揭示了针对代谢物化合物的不同反应
Keene L Abbott,Ahmed Ali,Dominick Casalena et al.
Keene L Abbott et al.
A challenge for screening new anticancer drugs is that efficacy in cell culture models is not always predictive of efficacy in patients. One limitation of standard cell culture is a reliance on non-physiological nutrient levels, which can i...
Profiling of drug resistance in Src kinase at scale uncovers a regulatory network coupling autoinhibition and catalytic domain dynamics [0.03%]
规模化剖析Src激酶的耐药性鉴定出一个调节网络，该网络将自动抑制和催化结构域动态相互连接
Sujata Chakraborty,Ethan Ahler,Jessica J Simon et al.
Sujata Chakraborty et al.
Kinase inhibitors are effective cancer therapies, but resistance often limits clinical efficacy. Despite the cataloging of numerous resistance mutations, our understanding of kinase inhibitor resistance is still incomplete. Here, we compreh...
Na Wang,Yu Qian,Ruixue Xia et al.
Na Wang et al.
CD97 (ADGRE5) is an adhesion G protein-coupled receptor (aGPCR) which plays crucial roles in immune system and cancer. However, the mechanism of CD97 activation and the determinant of G13 coupling selectivity remain unknown. Here, we presen...