Two sides of a co(i)ndensate [0.03%]
凝聚物的两面性
Emre Pekbilir,Dorothee Dormann
Emre Pekbilir
In the June 5th issue of Molecular Cell, Das et al.1 quantified the stability of condensates and fibrils formed from the prion-like low complexity region of hnRNPA1. They demonstrate that condensate interiors function as sinks and suppress ...
William Garland,Torben Heick Jensen
William Garland
In the June 12th issue of Cell, Baluapuri et al.1 report that loss of the Integrator (INT) complex triggers cellular stress by unleashing aberrant transcription, resulting in production of immunogenic double-stranded RNA. Dissecting early a...
Host-like conditions validate nutrient transport as an antimalarial drug target [0.03%]
宿主条件验证营养素转运作为抗疟疾药物靶点
Rodion Gordzevich,Eric D Brown
Rodion Gordzevich
Antimalarial drug discovery largely relies on nutrient-rich media that may obscure physiologically relevant targets. In this issue of Cell Chemical Biology, Molina et al.1 validate the plasmodial surface anion channel as essential for Plasm...
A cationic amphiphilic drug synergizes with strobilurin fungicides to control fungal-borne plant diseases [0.03%]
一个阳离子两亲性药物与琥珀酸脱氢酶抑制剂类杀菌剂联用控制病原真菌引起的植物病害研究
Bradley Laflamme,Christopher Blackman,Mackenzie Loranger et al.
Bradley Laflamme et al.
Fungal phytopathogens are responsible for major losses in agricultural yields annually. While the use of topical fungicides remains key to managing agricultural pathogens, the emergence of drug-resistant strains necessitates identifying add...
EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8+ T cell antitumor responses [0.03%]
EGR2的O-GlcNA酰化调控肿瘤促进型巨噬细胞向限制CD8⁺T细胞抗肿瘤反应方向分化
Yuchen Zhang,Hongpeng Li,Yi Hao et al.
Yuchen Zhang et al.
Tumor associated macrophages (TAMs) exhibit a high capacity to take up glucose. However, how metabolic cues derived from glucose rewire TAMs remains unclear. Here, we report that glucose metabolism-driven protein O-GlcNAcylation increases i...
Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation [0.03%]
OST催化亚基的冗余性便于N-糖基化的治疗靶向
Marta Baro,Hojin Lee,Vanessa Kelley et al.
Marta Baro et al.
Protein asparagine (N)-glycosylation, which promotes the folding and trafficking of cell surface receptors, has not traditionally been viewed as a viable target in oncology due to the essential and non-redundant enzymatic activities require...
Charting the development and engineering of CRISPR base editors: lessons and inspirations [0.03%]
CRISPR基础编辑的开发和工程化历程：经验与启示
Siyuan Zou,Yihong Sun,Weixin Tang
Siyuan Zou
CRISPR base editors (BEs) have introduced a new chapter in precise genome editing. The brief but fruitful history of BE development documents many case studies that not only lay the foundation of base-editing technology but are also instrum...
Mechanism by which the molecular glue-like verteporfin induces IRE1α dimerization and activation to synergize with AKT inhibition in breast cancer [0.03%]
分子胶verteporfin诱导IRE1α二聚化和活化并协同抑制AKT在乳腺癌中的机制研究
Yongliang Liu,Hui Hua,Yalan Cao et al.
Yongliang Liu et al.
Inositol-requiring enzyme 1α (IRE1α) signaling is one of three arms of the unfolded protein response, playing a vital role in maintaining endoplasmic reticulum homeostasis. Pharmacological modulation of this pathway offers potential thera...
Electrochemical sensor toolkit for simultaneous glutamate detection at edge of cleft and peri-soma [0.03%]
用于裂隙边缘和胞体周围同时检测谷氨酸的电化学生物传感器工具包
Jie Liu,Yuandong Liu,Dongmin Yin et al.
Jie Liu et al.
Simultaneously monitoring glutamate (Glu) dynamic at edge of synaptic cleft and peri-soma is crucial for understanding Glu-related pathology. Here, we created an electrochemical Glu sensors toolkit with spatial resolution of ∼60 nm, combin...
The critical role of PSAC channel in malaria parasite survival is driven home by phenotypic screening under relevant nutrient levels [0.03%]
针对营养水平相关的表型筛选证明了疟原虫离子通道PSAC在恶性疟原虫生存中的重要作用
Irene Molina,Ryan Mansell,Rui Liang et al.
Irene Molina et al.
Spreading resistance to front-line treatments necessitate the search for new classes of antimalarials. Limitations of standard screening conditions lead us to develop an assay using culture media that more closely reflects nutrient levels i...