Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury [0.03%]
油酸通过抑制铁依赖的细胞死亡(铁蛋白酶)减轻过量铁诱导的心肌损伤
Josiane Mann,Eduard Reznik,Melania Santer et al.
Josiane Mann et al.
Iron overload, characterized by accumulation of iron in tissues, induces a multiorgan toxicity whose mechanisms are not fully understood. Using cultured cell lines, Caenorhabditis elegans, and mice, we found that ferroptosis occurs in the c...
AGC kinase inhibitors regulate STING signaling through SGK-dependent and SGK-independent mechanisms [0.03%]
AGC激酶抑制剂通过SGK依赖和非依赖机制调节STING信号通路
Johnny Castillo Cabrera,Hong Dang,Adam Graves et al.
Johnny Castillo Cabrera et al.
Type 1 IFN expression is critical in the innate immune response, but aberrant expression is associated with autoimmunity and cancer. Here, we identify N-[4-(1H46 pyrazolo[3,4-b] pyrazin-6-yl)-phenyl]-sulfonamide (Sanofi-14h), a compound wit...
Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells [0.03%]
通过蛋白质的固有无序区域诱捕核孔中的超级增强子
Masaharu Hazawa,Dini Kurnia Ikliptikawati,Yuki Iwashima et al.
Masaharu Hazawa et al.
Master transcription factors such as TP63 establish super-enhancers (SEs) to drive core transcriptional networks in cancer cells, yet the spatiotemporal regulation of SEs within the nucleus remains unknown. The nuclear pore complex (NPC) ma...
Pharmacologic activation of a compensatory integrated stress response kinase promotes mitochondrial remodeling in PERK-deficient cells [0.03%]
药理学激活补偿性综合应激反应激酶可促进PERK缺陷细胞中的线粒体重塑
Valerie Perea,Kelsey R Baron,Vivian Dolina et al.
Valerie Perea et al.
The integrated stress response (ISR) comprises the eIF2α kinases PERK, GCN2, HRI, and PKR, which induce translational and transcriptional signaling in response to diverse insults. Deficiencies in PERK signaling lead to mitochondrial dysfun...
Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development [0.03%]
靶向伯氏疏螺旋体HtpG蛋白的一种新型抗微生物分子“berserker”
Dave L Carlson,Mark Kowalewski,Khaldon Bodoor et al.
Dave L Carlson et al.
Conventional antimicrobial discovery relies on targeting essential enzymes in pathogenic organisms, contributing to a paucity of new antibiotics to address resistant strains. Here, by targeting a non-essential enzyme, Borrelia burgdorferi H...
Photoaffinity labeling coupled with proteomics identify PDI-ADAM17 module is targeted by (-)-vinigrol to induce TNFR1 shedding and ameliorate rheumatoid arthritis in mice [0.03%]
photo亲和标记结合蛋白质组学鉴定出PDI-ADAM17模块为(-)-vinigrol作用靶点，通过促进TNFR1剪释改善小鼠类风湿关节炎
Yinhua Zhu,Lu Wang,Jing Li et al.
Yinhua Zhu et al.
Various biological agents have been developed to target tumor necrosis factor alpha (TNF-α) and its receptor TNFR1 for the rheumatoid arthritis (RA) treatment, whereas small molecules modulating such cytokine receptors are rarely reported ...
RNA G-quadruplex in functional regulation of noncoding RNA: Challenges and emerging opportunities [0.03%]
非编码RNA功能调控中的RNA G-四链体：挑战与机遇
Vinodh J Sahayasheela,Hiroshi Sugiyama
Vinodh J Sahayasheela
G-quadruplexes (G4s) are stable, noncanonical structures formed in guanine (G)-rich sequences of DNA/RNA. G4 structures are reported to play a regulatory role in various cellular processes and, recently, a considerable number of studies hav...
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening [0.03%]
一种促进捕获基因高水平表达的元基因组文库克隆策略以实现高效的功能筛选
Michelle H Rich,Abigail V Sharrock,Timothy S Mulligan et al.
Michelle H Rich et al.
Functional screening of environmental DNA (eDNA) libraries is a potentially powerful approach to discover enzymatic "unknown unknowns", but is usually heavily biased toward the tiny subset of genes preferentially transcribed and translated ...
Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs [0.03%]
靶向CD98hc的双特异性抗体转运体有效且长期地将IgG递送至大脑
Ghasidit Pornnoppadol,Layne G Bond,Michael J Lucas et al.
Ghasidit Pornnoppadol et al.
The inability of antibodies to penetrate the blood-brain barrier (BBB) is a key limitation to their use in diverse applications. One promising strategy is to deliver IgGs using a bispecific BBB shuttle, which involves fusing an IgG to a sec...
Blocking AMPKαS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity [0.03%]
阻断AMPKαS496磷酸化改善衰老和肥胖状态下的线粒体动力学和高血糖状态
Alexia Pearah,Balamurugan Ramatchandirin,Ting Liu et al.
Alexia Pearah et al.
Impaired mitochondrial dynamics causes aging-related or metabolic diseases. Yet, the molecular mechanism responsible for the impairment of mitochondrial dynamics is still not well understood. Here, we report that elevated blood insulin and/...