Lauren E Vostal,Tarun M Kapoor
Lauren E Vostal
Genetics-based approaches can enable drug target identification in human cells. In this issue of Cell Chemical Biology, Nguyen et al.1 use inducible degradation of a mismatch repair protein to tune the mutation rate in HCT116 cells, thereby...
Kevin N Dalby
Kevin N Dalby
The precise and selective quantification of drug-target interactions within the context of RAS-RAF heterodimers in live cells offers a powerful tool for drug development and personalized medicine, particularly in cancer research, where the ...
CryoEM structures of adhesion in GPCR CD97: Filling in some of the gaps [0.03%]
GPCR CD97的粘附 cryoEM结构：填补一些空白
Brian E Krumm,Bryan L Roth
Brian E Krumm
CD97 (ADGRE5) is an adhesion GPCR (aGPCR) that plays crucial roles in the immune system and cancer. In this issue of Cell Chemical Biology, Wang et al.1 present the cryoEM structures of CD97 in complex with G13, Gq, and Gs G protein subtype...
New advisory board members speak on challenges and opportunities in chemical biology [0.03%]
化学生物学的挑战与机遇——新一届编委会成员寄语
Xiang David Li,Chengqi Yi,Hang Hubert Yin et al.
Xiang David Li et al.
Cell Chemical Biology has recently added several advisory board members from China in an effort to better represent our authorship and readership. In this Voices piece, a few of the new members introduce themselves, give their perspective o...
Mishtu Dey
Mishtu Dey
Valerie Christin Zimmer,Anna Andrea Lauer,Viola Haupenthal et al.
Valerie Christin Zimmer et al.
Reduced sulfatide level is found in Alzheimer's disease (AD) patients. Here, we demonstrate that amyloid precursor protein (APP) processing regulates sulfatide synthesis and vice versa. Different cell culture models and transgenic mice mode...
Proteomics from compartment-specific APEX2 labeling in Mycobacterium tuberculosis reveals Type VII secretion substrates in the cell wall [0.03%]
基于分隔室特异性APEX2标记的结核杆菌蛋白质组学揭示细胞壁中的 VII 型分泌系统底物
Neetika Jaisinghani,Mary L Previti,Joshua Andrade et al.
Neetika Jaisinghani et al.
The cell wall of mycobacteria plays a key role in interactions with the environment. Its ability to act as a selective filter is crucial to bacterial survival. Proteins in the cell wall enable this function by mediating the import and expor...
Anticancer benzoxaboroles block pre-mRNA processing by directly inhibiting CPSF3 [0.03%]
抗癌症苯并氧基硼化合物通过直接抑制CPSF3来阻断前mRNA的加工
Ye Tao,Albert Budhipramono,Ji Huang et al.
Ye Tao et al.
A novel class of benzoxaboroles was reported to induce cancer cell death but the mechanism was unknown. Using a forward genetics platform, we discovered mutations in cleavage and polyadenylation specific factor 3 (CPSF3) that reduce benzoxa...
Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest [0.03%]
细胞周期停滞与铁死亡协同诱导癌细胞凋零
Jason Rodencal,Nathan Kim,Andrew He et al.
Jason Rodencal et al.
Ferroptosis is a non-apoptotic form of cell death that can be triggered by inhibiting the system xc- cystine/glutamate antiporter or the phospholipid hydroperoxidase glutathione peroxidase 4 (GPX4). We have investigated how cell cycle arres...
Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy [0.03%]
具有双重抑制功能的PD-L1靶向抗原抗体寡核苷酸免疫治疗系统抗肿瘤效应研究
Fatao Luo,Gang Yang,Xia Bai et al.
Fatao Luo et al.
Checkpoint inhibitor antibody therapy by blocking the interaction of surface programmed death-ligand 1(PD-L1) and programmed cell death protein 1(PD-1) has promising advantages in cancer immunotherapy. However, the response of many patients...