Yaxin Hu,Cheuk Yin Li,Qiuyu Lu et al.
Yaxin Hu et al.
Accurately characterizing cell types within complex cell structures provides invaluable information for comprehending the cellular status during biological processes. In this study, we have developed an miRNA-switch cocktail platform capabl...
Discovery of antibiotics that selectively kill metabolically dormant bacteria [0.03%]
能够选择性杀灭代谢休眠细菌的抗生素的发现
Erica J Zheng,Jacqueline A Valeri,Ian W Andrews et al.
Erica J Zheng et al.
There is a need to discover and develop non-toxic antibiotics that are effective against metabolically dormant bacteria, which underlie chronic infections and promote antibiotic resistance. Traditional antibiotic discovery has historically ...
PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer [0.03%]
降解PIM1可防止前列腺癌产生化疗耐药性
Pedro Torres-Ayuso,Meghri Katerji,Dawid Mehlich et al.
Pedro Torres-Ayuso et al.
PIM kinases have important pro-tumorigenic roles and mediate several oncogenic traits, including cell proliferation, survival, and chemotherapeutic resistance. As a result, multiple PIM inhibitors have been pursued as investigational new dr...
Jennifer E Collins,Jin Woo Lee,Frances Rocamora et al.
Jennifer E Collins et al.
Our previous study identified 52 antiplasmodial peptaibols isolated from fungi. To understand their antiplasmodial mechanism of action, we conducted phenotypic assays, assessed the in vitro evolution of resistance, and performed a transcrip...
Lu Xiao,Linglan Fang,Eric T Kool
Lu Xiao
RNA plays pivotal roles in most cellular processes, serving as both the traditional carrier of genetic information and as a key regulator of cellular functions. The advent of chemical technologies has contributed critically to the analysis ...
Serotonin is a common thread linking different classes of antidepressants [0.03%]
血清素是不同抗抑郁药物的共同作用链式反应环节
Colby E Witt,Sergio Mena,Jordan Holmes et al.
Colby E Witt et al.
Depression pathology remains elusive. The monoamine hypothesis has placed much focus on serotonin, but due to the variable clinical efficacy of monoamine reuptake inhibitors, the community is looking for alternative therapies such as ketami...
Isabel C Lane,Gabriele Kembuan,Jeannie Carreiro et al.
Isabel C Lane et al.
Chimeric antigen receptor (CAR) T cell therapies are medical breakthroughs in cancer treatment. However, treatment failure is often caused by CAR T cell dysfunction. Additional approaches are needed to overcome inhibitory signals that limit...
Tracking neurodegenerative diseases in biofluids: Combining pathology and pathophysiology markers is the way [0.03%]
结合病理和病理生理标志物监测生物液体中的神经退行性疾病是一种方法学思路
Andrea Mastrangelo,Angela Mammana,Piero Parchi
Andrea Mastrangelo
Biofluid biomarkers to track neurodegenerative diseases in vitam are urgently needed. Recent studies show that large-scale proteomic analyses based on the proximity extension assay may reveal novel biomarkers reflecting disease pathophysiol...
Come for the atmosphere, stay for the interactions: Deciphering small molecule partitioning into biomolecular condensates [0.03%]
氛围中来，互动里留——解析小分子进入生物大分子凝聚体中的分配行为
Bakhtyar Sepehri,Kevin Drew,José A Villegas
Bakhtyar Sepehri
Optimizing pharmacokinetic properties remains challenging but is generally guided by a set of structural rules. However, no such rule set exists for intracellular distribution. Kilgore et al.1 have examined small molecule partitioning withi...
Addicted to proteostasis: How KRAS-driven cancers acquire resistance to clinical KRAS inhibitors [0.03%]
上瘾的蛋白质稳态：KRAS驱动的癌症如何获得对临床KRAS抑制剂的耐药性
Austin T Klein,Marc L Mendillo
Austin T Klein
The development of KRAS inhibitors was a remarkable feat, yet their efficacy is limited by inevitable resistance. In the September issue of Science, Lv et al.1 demonstrate how KRAS-driven cancers rewire signaling to restore protein homeosta...