Cell Chemical Biology editorial team
Cell Chemical Biology editorial team
Continuing the celebration of Cell Chemical Biology's 30th anniversary, this focus issue presents the spectrum of ways that bioorthogonal chemistry empowers biological and biomedical studies. The following opinion pieces, reviews, and resea...
FLEX: genetically encodable enzymatic fluorescence signal amplification using engineered peroxidase [0.03%]
基于工程过氧化物酶的遗传编码型酶学生化信号放大技术
Nirmali Sharma,Minkyo Jung,Pratyush Kumar Mishra et al.
Nirmali Sharma et al.
Fluorescent tagging of biomolecules enables their sensitive detection during separation and determining their subcellular location. In this context, peroxidase-based reactions are actively utilized for signal amplification. To harness this ...
PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC-I expression and blocks HIV-1 replication [0.03%]
利用靶向蛋白降解技术敲低HIV-1 Nef可有效恢复细胞表面CD4和MHC-I的表达并抑制HIV-1复制
Lori A Emert-Sedlak,Colin M Tice,Haibin Shi et al.
Lori A Emert-Sedlak et al.
The HIV-1 Nef accessory factor enhances the viral life cycle in vivo, promotes immune escape of HIV-infected cells, and represents an attractive antiretroviral drug target. However, Nef lacks enzymatic activity and an active site, complicat...
Chemical immunology: Recent advances in tool development and applications [0.03%]
化学免疫学：研究工具开发和应用的近期进展
Yujie Shi,Eleanor E Bashian,Yingqin Hou et al.
Yujie Shi et al.
Immunology was one of the first biological fields to embrace chemical approaches. The development of new chemical approaches and techniques has provided immunologists with an impressive arsenal of tools to address challenges once considered...
Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome [0.03%]
选择性针对恶性疟原虫Hsp90可破坏26S蛋白酶体
Christopher R Mansfield,Baiyi Quan,Michael E Chirgwin et al.
Christopher R Mansfield et al.
The molecular chaperone heat shock protein 90 (Hsp90) has an essential but largely undefined role in maintaining proteostasis in Plasmodium falciparum, the most lethal malaria parasite. Herein, we identify BX-2819 and XL888 as potent P. fal...
A proximity labeling-based orthogonal trap strategy identifies HDAC8 promotes cell motility by modulating cortactin acetylation [0.03%]
基于接近标记的正交捕获策略识别HDAC8通过调节cortactin乙酰化促进细胞运动
Yepei Huang,Guijin Zhai,Yun Fu et al.
Yepei Huang et al.
It is a challenge for the traditional affinity methods to capture transient interactions of enzyme-post-translational modification (PTM) substrates in vivo. Herein we presented a strategy termed proximity labeling-based orthogonal trap appr...
A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened [0.03%]
一种甾醇类似物通过阻断刺猬平滑蛋白的胆固醇化来抑制刺猬信号通路
Yuan-Bin Liu,Li-Ming He,Ming Sun et al.
Yuan-Bin Liu et al.
The hedgehog (Hh) signaling pathway has long been a hotspot for anti-cancer drug development due to its important role in cell proliferation and tumorigenesis. However, most clinically available Hh pathway inhibitors target the seven-transm...
Nicole M Chapman,Hongbo Chi
Nicole M Chapman
The immune system shapes tumor development and progression. Although immunotherapy has transformed cancer treatment, its overall efficacy remains limited, underscoring the need to uncover mechanisms to improve therapeutic effects. Metabolis...
Allosteric inhibition of tRNA synthetase Gln4 by N-pyrimidinyl-β-thiophenylacrylamides exerts highly selective antifungal activity [0.03%]
N-嘧啶基-β-噻吩基丙烯酰胺通过异构抑制tRNA合成酶Gln4来发挥高效选择性抗真菌活性
Emily Puumala,David Sychantha,Elizabeth Lach et al.
Emily Puumala et al.
Candida species are among the most prevalent causes of systemic fungal infections, which account for ∼1.5 million annual fatalities. Here, we build on a compound screen that identified the molecule N-pyrimidinyl-β-thiophenylacrylamide (NP...
CYP7B1-mediated 25-hydroxycholesterol degradation maintains quiescence-activation balance and improves therapeutic potential of mesenchymal stem cells [0.03%]
CYP7B1介导的25-羟基胆固醇降解维持静息激活平衡并提高间充质干细胞的治疗潜力
Zhaoqiang Zhang,Zepeng Su,Zhikun Li et al.
Zhaoqiang Zhang et al.
Stem cells remain quiescent in vivo and become activated in response to external stimuli. However, the mechanism regulating the quiescence-activation balance of bone-marrow-derived mesenchymal stem cells (BM-MSCs) is still unclear. Herein, ...