Multiparatopic antibodies induce targeted downregulation of programmed death-ligand 1 [0.03%]
多价抗体诱导程序性死亡配体-1的靶向下调
Seth D Ludwig,Bunyarit Meksiriporn,Jiacheng Tan et al.
Seth D Ludwig et al.
Published Erratum
Cell chemical biology. 2024 May 16;31(5):1023. DOI:10.1016/j.chembiol.2024.04.011 2024
Steve D Knutson,Benito F Buksh,Sean W Huth et al.
Steve D Knutson et al.
Understanding the intricate network of biomolecular interactions that govern cellular processes is a fundamental pursuit in biology. Over the past decade, photocatalytic proximity labeling has emerged as one of the most powerful and versati...
Xuekun Fu,Jin Li,Xinxin Chen et al.
Xuekun Fu et al.
Proteolysis-targeting chimeras (PROTACs) are heterobifunctional molecules consisting of two ligands joined by a linker, enabling them to simultaneously bind with an E3 ligase and a protein of interest (POI) and trigger proteasomal degradati...
Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors [0.03%]
一种激活肿瘤坏死因子受体的双表位抗体的简易生成方式
Harkamal S Jhajj,John S Schardt,Namir Khalasawi et al.
Harkamal S Jhajj et al.
Agonist antibodies are being pursued for therapeutic applications ranging from neurodegenerative diseases to cancer. For the tumor necrosis factor (TNF) receptor superfamily, higher-order clustering of three or more receptors is key to thei...
SARS-CoV-2 resistance to monoclonal antibodies and small-molecule drugs [0.03%]
新型冠状病毒对单克隆抗体和小分子药物的抗性
Sho Iketani,David D Ho
Sho Iketani
Over four years have passed since the beginning of the COVID-19 pandemic. The scientific response has been rapid and effective, with many therapeutic monoclonal antibodies and small molecules developed for clinical use. However, given the a...
Longfei Gao,Lei Ding
Longfei Gao
The tumor microenvironment (TME) dictates the outcome of cancer immunotherapy. In this issue of Cell Chemical Biology, Yu et al.1 report that targeting Mettl3 leads to a more inflamed, "hot" TME and effective anti-PD-1 therapy. This study p...
Wendy Le Mouëllic,Yannick Poquet,Olivier Neyrolles
Wendy Le Mouëllic
In this issue of Cell Chemical Biology, Gries et al.1 employ an innovative screening approach to identify anti-tuberculosis compounds with dual modes of action: anti-virulence against the type VII secretion system ESX-1 and enhanced ethiona...
Meet the Authors: Christopher R. Mansfield and Emily R. Derbyshire [0.03%]
作者见面会：Christopher R. Mansfield 和 Emily R. Derbyshire
Christopher R Mansfield,Emily R Derbyshire
Christopher R Mansfield
In an interview with Samantha Nelson, a scientific editor of Cell Chemical Biology, the first and corresponding authors of the research article entitled Selective targeting of Plasmodium falciparum Hsp90 disrupts the 26S proteasome share mo...
Lori Emert-Sedlak,Tom Smithgall
Lori Emert-Sedlak
In an interview with Samantha Nelson, a scientific editor of Cell Chemical Biology, the first and corresponding authors of the research article entitled "PROTAC-mediated degradation of HIV-1 Nef efficiently restores cell-surface CD4 and MHC...
Jordan B Jastrab,Jonathan C Kagan
Jordan B Jastrab
Mammalian innate immunity is regulated by pattern-recognition receptors (PRRs) and guard proteins, which use distinct strategies to detect infections. PRRs detect bacterial molecules directly, whereas guards detect host cell manipulations b...