Metabolism-inflammasome crosstalk shapes innate and adaptive immunity [0.03%]
代谢-炎性小体互作塑造先天性和适应性免疫反应
Jun Wu,Xuan Sun,Peng Jiang
Jun Wu
Inflammasomes are a central component of innate immunity and play a vital role in regulating innate immune response. Activation of inflammasomes is also indispensable for adaptive immunity, modulating the development and response of adaptiv...
Sharks give a handle to potent anti-tumor multiparatopic antibodies inducing membrane depletion of PD-L1 [0.03%]
鲨鱼抗体助力开发潜在抗肿瘤多识别表位抗体诱导PD-L1脱色疗法
Gordana Wozniak-Knopp,Veronica Natale
Gordana Wozniak-Knopp
Despite the immense clinical success of the antibody therapeutics that neutralize programmed death receptor ligand 1 (PD-L1) and thus resurrect T cell antitumor activity, the patient response rates remain low. In this issue of Cell Chemical...
Yuezhou Chen,Fiachra Humphries,Ming O Li et al.
Yuezhou Chen et al.
The rise of immunotherapy and mRNA vaccines has underscored the power of modulating the immune system for a desired response. In this Voices piece, the Cell Chemical Biology editors ask researchers from a range of backgrounds: what are some...
Finding my leadership style [0.03%]
发现我的领导风格
Helen Walden
Helen Walden
In this Stories piece, Dr. Helen Walden-Professor and Head of the School of Molecular Biosciences at the University of Glasgow-shares how her past experiences and academic journey have shaped her leadership style. ...
Meet the Authors: Harkamal S. Jhajj and Peter M. Tessier [0.03%]
作者见面会：Harkamal S. Jhajj 和 Peter M. Tessier
Harkamal S Jhajj,Peter M Tessier
Harkamal S Jhajj
In an interview with Dr. Mishtu Dey, Editor-in-chief of Cell Chemical Biology, two authors of the Technology article entitled "Facile generation of biepitopic antibodies with intrinsic agonism for activating tumor necrosis factor receptors"...
In an interview with Dr. Samantha Nelson, a scientific editor for Cell Chemical Biology, the authors of the Perspective "Strategies of bacterial detection by inflammasomes" share their views on the field and their lives as scientists. ...
Behavioral control through the direct, focal silencing of neuronal activity [0.03%]
通过直接聚焦于神经元活动的 silenced 成像来控制行为
Anna V Elleman,Nikola Milicic,Damian J Williams et al.
Anna V Elleman et al.
The ability to optically stimulate and inhibit neurons has revolutionized neuroscience research. Here, we present a direct, potent, user-friendly chemical approach for optically silencing neurons. We have rendered saxitoxin (STX), a natural...
Lingyin Li
Lingyin Li
Ten years ago, the second messenger cGAMP was discovered as the activator of the anti-cancer STING pathway. The characterization of cGAMP's paracrine action and dominant extracellular hydrolase ENPP1 cemented cGAMP as an intercellular immun...
Molecular glues for protein-protein interactions: Progressing toward a new dream [0.03%]
蛋白质-蛋白质相互作用的分子胶：迈向新梦想的进步
Markella Konstantinidou,Michelle R Arkin
Markella Konstantinidou
The modulation of protein-protein interactions with small molecules is one of the most rapidly developing areas in drug discovery. In this review, we discuss advances over the past decade (2014-2023) focusing on molecular glues (MGs)-monova...
Molecular glues and induced proximity: An evolution of tools and discovery [0.03%]
分子胶和诱导接近：工具与发现的进化
Stephanie Anne Robinson,Jennifer Anne Co,Steven Mark Banik
Stephanie Anne Robinson
Small molecule molecular glues can nucleate protein complexes and rewire interactomes. Molecular glues are widely used as probes for understanding functional proximity at a systems level, and the potential to instigate event-driven pharmaco...