Jan Gerhartz,Radosław P Nowak
Jan Gerhartz
In this issue of Cell Chemical Biology, Lu et al.1 report the discovery of a bivalent KEAP1 inhibitor (biKEAP1), which more rapidly activates NRF2 compared to previously reported monovalent KEAP1 inhibitors. biKEAP1suppresses acute inflamma...
Lucie Wolf,Stephane Angers
Lucie Wolf
Pharmacological modulation of the Wnt/β-catenin signaling pathway holds promises for both basic research and therapeutic applications. In this issue of Cell Chemical Biology, Kschonsak et al.1 engineered knotted peptides that promote Wnt s...
Velcrin compounds activate the SLFN12 tRNase to induce tomoptosis [0.03%]
Velcrin化合物激活SLFN12内切酶诱导膜依赖性细胞死亡
Heidi Greulich
Heidi Greulich
Velcrins are molecular glues that induce complex formation between PDE3A and SLFN12. The PDE3A-SLFN12 complex activates the SLFN12 RNase, resulting in cleavage of the specific substrate, tRNA-Leu-TAA, global inhibition of translation, and d...
Angela Cacace,Danette Daniels,Fleur M Ferguson et al.
Angela Cacace et al.
In this Voices piece, the Cell Chemical Biology editors ask researchers from a range of backgrounds: what are some exciting discoveries in the induced proximity field and the next frontier for therapeutic development? ...
Joshua P Smalley
Joshua P Smalley
In this Stories piece, Josh Smalley, a postdoctoral research associate at the University of Leicester and finalist of The Great British Bake Off, discusses the parallels between chemistry and baking, revealing how he successfully combines t...
Meet the authors: Lauren Kageler, Jonathan Perr, and Ryan A. Flynn [0.03%]
作者见面会：Lauren Kageler、Jonathan Perr和Ryan A. Flynn
Lauren Kageler,Jonathan Perr,Ryan A Flynn
Lauren Kageler
In an interview with Dr. Mishtu Dey, editor-in-chief of Cell Chemical Biology, the authors of the review titled "Tools to investigate the cell surface: Proximity as a central concept in glycoRNA biology"-Lauren Kageler, Jonathan Perr, and D...
Meet the authors: Markella Konstantinidou and Michelle R. Arkin [0.03%]
作者见面会：Markella Konstantinidou和Michelle R. Arkin
Markella Konstantinidou,Michelle R Arkin
Markella Konstantinidou
In an interview with Dr. Ying Li, a scientific editor of Cell Chemical Biology, the authors of the Review titled "Molecular glues for protein-protein interactions: Progressing toward a new dream" share their perspectives on their field and ...
Cell Chemical Biology editorial team
Cell Chemical Biology editorial team
In celebration of Cell Chemical Biology's 30th anniversary, the editorial team presents a special issue, "Induced proximity in biology and therapeutics," to highlight a rapidly growing research area with significant promise for scientific d...
Chemoproteomic profiling of substrate specificity in gut microbiota-associated bile salt hydrolases [0.03%]
肠道微生物群相关胆盐水解酶的底物特异性化学蛋白质组学剖析
Lin Han,Augustus Pendleton,Adarsh Singh et al.
Lin Han et al.
The gut microbiome possesses numerous biochemical enzymes that biosynthesize metabolites that impact human health. Bile acids comprise a diverse collection of metabolites that have important roles in metabolism and immunity. The gut microbi...
RNATACs: Multispecific small molecules targeting RNA by induced proximity [0.03%]
RNA-TACs：通过诱导靠近作用的多特异性小分子RNA靶向分子
Yan Song,Jia Cui,Jiaqiang Zhu et al.
Yan Song et al.
RNA-targeting small molecules (rSMs) have become an attractive modality to tackle traditionally undruggable proteins and expand the druggable space. Among many innovative concepts, RNA-targeting chimeras (RNATACs) represent a new class of m...