Feel the breeze: Opening the therapeutic window with RIPTACs and induced proximity [0.03%]
逐风而行：利用RIPTAC和诱导接近疗法开启治疗窗口
Kyle Mangano,Patrick Ryan Potts
Kyle Mangano
In this issue of Cell Chemical Biology, Raina et al.1 demonstrate proof of concept of a new chemical induced proximity strategy for targeted cancer therapeutics. Building on a recent surge in induced proximity modalities, RIPTACs represent ...
Thomas R Cech,Emmanuelle Charpentier,Aaron Ciechanover et al.
Thomas R Cech et al.
Since the first award in 1901, the Nobel Prize has come to signify the pinnacle of scientific achievement. In this Voices piece in the August special issue of Cell Chemical Biology entitled "Bridging chemistry and biology," we ask Nobel lau...
Carolyn Bertozzi: Building new bonds between molecules, fields, and communities [0.03%]
卡罗琳·贝尔托齐：构筑分子、领域和社群之间的新联系
Matthew R Pratt,Jennifer A Prescher
Matthew R Pratt
Mixed alkyl/aryl phosphonates identify metabolic serine hydrolases as antimalarial targets [0.03%]
混合的烷基/芳族磷化物确定代谢型丝氨酸水解酶是抗疟新药靶点
John M Bennett,Sunil K Narwal,Stephanie Kabeche et al.
John M Bennett et al.
Malaria, caused by Plasmodium falciparum, remains a significant health burden. One major barrier for developing antimalarial drugs is the ability of the parasite to rapidly generate resistance. We previously demonstrated that salinipostin A...
Precision epigenetic editing: Technological advances, enduring challenges, and therapeutic applications [0.03%]
精确的表观遗传编辑：技术进步、持久挑战及治疗应用
Goldie V Roth,Isabella R Gengaro,Lei S Qi
Goldie V Roth
The epigenome is a complex framework through which gene expression is precisely and flexibly modulated to incorporate heritable memory and responses to environmental stimuli. It governs diverse cellular processes, including cell fate, disea...
Regulated induced proximity targeting chimeras-RIPTACs-A heterobifunctional small molecule strategy for cancer selective therapies [0.03%]
受体调控的诱导接近靶向嵌合分子(RIPTAC)一种针对癌症的选择性治疗方法的小分子异双功能策略
Kanak Raina,Chris D Forbes,Rebecca Stronk et al.
Kanak Raina et al.
We describe a protein proximity inducing therapeutic modality called Regulated Induced Proximity Targeting Chimeras or RIPTACs: heterobifunctional small molecules that elicit a stable ternary complex between a target protein (TP) selectivel...
Rob C Oslund,Pamela M Holland,Scott A Lesley et al.
Rob C Oslund et al.
The growing clinical success of bispecific antibodies (bsAbs) has led to rapid interest in leveraging dual targeting in order to generate novel modes of therapeutic action beyond mono-targeting approaches. While bsAbs that bind targets on t...
Septins promote macrophage pyroptosis by regulating gasdermin D cleavage and ninjurin-1-mediated plasma membrane rupture [0.03%]
Septin通过调节Gasdermin D的裂解和NINJ1介导的质膜破裂促进巨噬细胞焦亡
Dominik Brokatzky,Margarida C Gomes,Stevens Robertin et al.
Dominik Brokatzky et al.
The septin cytoskeleton is primarily known for roles in cell division and host defense against bacterial infection. Despite recent insights, the full breadth of roles for septins in host defense is poorly understood. In macrophages, Shigell...
Kai Papenfort,Gisela Storz
Kai Papenfort
The study of small, regulatory RNAs (sRNA) that act by base-pairing with target RNAs in bacteria has been steadily advancing, particularly with the availability of more and more transcriptome and RNA-RNA interactome datasets. While the char...
Qian Li,Hanzhong Feng,Qiong Tian et al.
Qian Li et al.
The rapid rise of antibiotic resistance calls for the discovery of new antibiotics with distinct antibacterial mechanisms. New target mining is indispensable for developing antibiotics. Plant-microbial antibiotics are appealing to underexpl...