Chemical induction of the interaction between AIMP2-DX2 and Siah1 to enhance ubiquitination [0.03%]
化学诱导AIMP2-DX2与Siah1相互作用以增强泛素化反应
Dae Gyu Kim,Minkyoung Kim,Ja-Il Goo et al.
Dae Gyu Kim et al.
AIMP2-DX2 (hereafter DX2) is an oncogenic variant of aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) that mediates tumorigenic interactions with various factors involved in cancer. Reducing the levels of DX2 can effe...
The best of both worlds: Chemigenetic fluorescent sensors for biological imaging [0.03%]
兼而有之：化学遗传学荧光传感器用于生物成像
Kelvin K Tsao,Shosei Imai,Michael Chang et al.
Kelvin K Tsao et al.
Synthetic-based fluorescent chemosensors and protein-based fluorescent biosensors are two well-established classes of tools for visualizing and monitoring biological processes in living tissues. Chemigenetic sensors, created using a combina...
A chemical screen identifies PRMT5 as a therapeutic vulnerability for paclitaxel-resistant triple-negative breast cancer [0.03%]
一项化学筛查发现PRMT5是治疗三阴乳腺癌紫杉醇耐药性的潜在药物靶点
KeJing Zhang,Juan Wei,SheYu Zhang et al.
KeJing Zhang et al.
Paclitaxel-resistant triple negative breast cancer (TNBC) remains one of the most challenging breast cancers to treat. Here, using an epigenetic chemical probe screen, we uncover an acquired vulnerability of paclitaxel-resistant TNBC cells ...
Hao Ye,Guangyu Luo,Zhenwu Zheng et al.
Hao Ye et al.
Yeast has been extensively studied and engineered due to its genetic amenability. Projects like Sc2.0 and Sc3.0 have demonstrated the feasibility of constructing synthetic yeast genomes, yielding promising results in both research and indus...
Engineering acyclovir-induced RNA nanodevices for reversible and tunable control of aptamer function [0.03%]
利用阿昔洛韦工程RNA纳米装置实现适配体功能的可调和可逆调控
Timo Hagen,Jacob L Litke,Nahian Nasir et al.
Timo Hagen et al.
Small molecule-regulated RNA devices have the potential to modulate diverse aspects of cellular function, but the small molecules used to date have potential toxicities limiting their use in cells. Here we describe a method for creating dru...
Chemoproteomics reveals immunogenic and tumor-associated cell surface substrates of ectokinase CK2α [0.03%]
化学蛋白质组学揭示了外源激酶CK2α的免疫原性和肿瘤相关细胞表面底物
Corleone S Delaveris,Sophie Kong,Jeff Glasgow et al.
Corleone S Delaveris et al.
Foreign epitopes for immune recognition provide the basis of anticancer immunity. Due to the high concentration of extracellular adenosine triphosphate in the tumor microenvironment, we hypothesized that extracellular kinases (ectokinases) ...
Emerging biochemical, microbial and immunological evidence in the search for why HLA-B∗27 confers risk for spondyloarthritis [0.03%]
HLA-B*27分子致轴向脊柱关节炎易感的生物化学、微生物及免疫学新证据
Eric M Brown,Phuong N U Nguyen,Ramnik J Xavier
Eric M Brown
The strong association of the human leukocyte antigen B∗27 alleles (HLA-B∗27) with spondyloarthritis and related rheumatic conditions has long fascinated researchers, yet the precise mechanisms underlying its pathogenicity remain elusive....
Human AKR1C3 binds agonists of GPR84 and participates in an expanded polyamine pathway [0.03%]
人AKR1C3结合GPR84激动剂并参与扩增的聚胺代谢途径
Natavan Dudkina,Hyun Bong Park,Deguang Song et al.
Natavan Dudkina et al.
Altered human aldo-keto reductase family 1 member C3 (AKR1C3) expression has been associated with poor prognosis in diverse cancers, ferroptosis resistance, and metabolic diseases. Despite its clinical significance, the endogenous biochemic...
The chemistry of electrical signaling in sodium channels from bacteria and beyond [0.03%]
细菌钠通道及其同类通道的电荷-to-信号转换机制
William A Catterall,Tamer M Gamal El-Din,Goragot Wisedchaisri
William A Catterall
Electrical signaling is essential for all fast processes in biology, but its molecular mechanisms have been uncertain. This review article focuses on studies of bacterial sodium channels in order to home in on the essential molecular and ch...
Xueqin Jin,Jian Huang,Huan Wang et al.
Xueqin Jin et al.
Voltage-gated sodium (Nav) and calcium (Cav) channels are responsible for the initiation of electrical signals. They have long been targeted for the treatment of various diseases. The mounting number of cryoelectron microscopy (cryo-EM) str...