Mechanisms by which microbiome-derived metabolites exert their impacts on neurodegeneration [0.03%]
微生物衍生代谢物影响神经退行性疾病的机制研究
Lara Kern,Ignacio Mastandrea,Anna Melekhova et al.
Lara Kern et al.
Recent developments in microbiome research suggest that the gut microbiome may remotely modulate central and peripheral neuronal processes, ranging from early brain development to age-related changes. Dysbiotic microbiome configurations hav...
New therapies on the horizon: Targeted protein degradation in neuroscience [0.03%]
靶向蛋白降解在神经科学中的新疗法展望
James A Gregory,Christopher M Hickey,Juan Chavez et al.
James A Gregory et al.
This minireview explores the burgeoning field of targeted protein degradation (TPD) and its promising applications in neuroscience and clinical development. TPD offers innovative strategies for modulating protein levels, presenting a paradi...
Advances in spatial proteomics: Mapping proteome architecture from protein complexes to subcellular localizations [0.03%]
空间蛋白质组学进展：从蛋白质复合物到亚细胞定位的蛋白质组结构映射
Lisa M Breckels,Charlotte Hutchings,Kishor D Ingole et al.
Lisa M Breckels et al.
Proteins are responsible for most intracellular functions, which they perform as part of higher-order molecular complexes, located within defined subcellular niches. Localization is both dynamic and context specific and mislocalization unde...
Micah J Niphakis,Benjamin F Cravatt
Micah J Niphakis
Genomic technologies have led to massive gains in our understanding of human gene function and disease relevance. Chemical biologists are a primary beneficiary of this information, which can guide the prioritization of proteins for chemical...
Anne-Claire Jacomin,Ivan Dikic
Anne-Claire Jacomin
The dynamic process of membrane shaping and remodeling plays a vital role in cellular functions, with proteins and cellular membranes interacting intricately to adapt to various cellular needs and environmental cues. Ubiquitination-a posttr...
Tina W Han,Bede Portz,Richard A Young et al.
Tina W Han et al.
Biomolecular condensates are dynamic membraneless organelles that compartmentalize proteins and RNA molecules to regulate key cellular processes. Diverse RNA species exert their effects on the cell by their roles in condensate formation and...
Cigall Kadoch,Jason M Sheltzer,Hang Yin
Cigall Kadoch
In early October, the Nobel Prizes will honor groundbreaking discoveries. After the anticipated recognition of Katalin Karikó and Drew Weissman in 2023 for the development of RNA modifications that enabled the SARS-CoV-2 mRNA vaccine, we e...
What is chemical biology? [0.03%]
什么是化学生物学？
Albert A Antolin,Yimon Aye,Liron Bar-Peled et al.
Albert A Antolin et al.
Since its inception, the chemical biology field has undergone significant evolution, with its definition varying greatly based on individual perspectives. For the September 30th anniversary special issue of Cell Chemical Biology, we asked o...
Celebrating 30 years of chemical biology: A toast to multidisciplinarity [0.03%]
庆祝化学生物学三十年：举杯共饮多学科融合之果
Mishtu Dey,Samantha Nelson
Mishtu Dey
In celebration of the 30th anniversary of Cell Chemical Biology, the editors introduce the September special issue and reflect on the significant evolution and multidisciplinary nature of the chemical biology field and the journal since its...
Insights into lysophosphatidylserine recognition and Gα12/13-coupling specificity of P2Y10 [0.03%]
P2Y10识别溶血磷脂酰丝氨酸的机制及其偶联Gα12/13的特异性的研究
Han Yin,Nozomi Kamakura,Yu Qian et al.
Han Yin et al.
The lysophosphatidylserine (LysoPS) receptor P2Y10, also known as LPS2, plays crucial roles in the regulation of immune responses and holds promise for the treatment of autoimmune diseases. Here, we report the cryoelectron microscopy (cryo-...