RNA infrastructure profiling illuminates transcriptome structure in crowded spaces [0.03%]
RNA基础设施分析揭示拥挤空间中的转录组结构
Lu Xiao,Linglan Fang,Wenrui Zhong et al.
Lu Xiao et al.
RNAs fold into compact structures and undergo protein interactions in cells. These occluded environments can block reagents that probe the underlying RNAs. Probes that can analyze structure in crowded settings can shed light on RNA biology....
Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking [0.03%]
脂质可用性通过调节多不饱和脂肪酸的运输影响癌细胞的铁死亡敏感性
Kelly H Sokol,Cameron J Lee,Thomas J Rogers et al.
Kelly H Sokol et al.
Ferroptosis is a form of cell death caused by lipid peroxidation that is emerging as a target for cancer therapy, highlighting the need to identify factors that govern ferroptosis susceptibility. Lipid peroxidation occurs primarily on phosp...
Jujun Zhou,Qin Chen,Ren Ren et al.
Jujun Zhou et al.
DNA methylation, as exemplified by cytosine-C5 methylation in mammals and adenine-N6 methylation in bacteria, is a key epigenetic process. Developing non-nucleoside inhibitors to cause DNA hypomethylation is crucial for treating various con...
Sarah J McAnulty
Sarah J McAnulty
In this Stories piece, Sarah J. McAnulty, the executive director of Skype a Scientist and an assistant research professor at the University of Connecticut, discusses the importance of scientists connecting with their local communities to pr...
Uncovering lipid dynamics in Staphylococcus aureus osteomyelitis using multimodal imaging mass spectrometry [0.03%]
利用多模影像质谱法揭示金黄色葡萄球菌骨髓炎中的脂质动力学
Christopher J Good,Casey E Butrico,Madeline E Colley et al.
Christopher J Good et al.
Osteomyelitis occurs when Staphylococcus aureus invades the bone microenvironment, resulting in a bone marrow abscess with a spatially defined architecture of cells and biomolecules. Imaging mass spectrometry and microscopy are tools that c...
Reducing CRISPR-Cas9 off-target effects by optically controlled chemical modifications of guide RNA [0.03%]
利用光学控制的化学修饰降低CRISPR-Cas9脱靶效应
Qianqian Qi,Xingyu Liu,Wei Xiong et al.
Qianqian Qi et al.
A photocatalytic click chemistry approach, offering a significant advancement over conventional methods in RNA function modulation is described. This innovative method, utilizing light-activated small molecules, provides a high level of pre...
Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer [0.03%]
SMARCA4突变癌症中SMARCA2降解剂的治疗作用源于增强子重新编程
Sasikumar Kotagiri,Nicholas Blazanin,Yuanxin Xi et al.
Sasikumar Kotagiri et al.
Genomic studies have identified frequent mutations in subunits of the SWI/SNF (switch/sucrose non-fermenting) chromatin remodeling complex including SMARCA4 and ARID1A in non-small cell lung cancer (NSCLC). Genetic evidence indicates that t...
A tau dephosphorylation-targeting chimeraselectively recruits protein phosphatase-1 to ameliorate Alzheimer's disease and tauopathies [0.03%]
一种tau去磷酸化靶向嵌合酶可选择性募集蛋白磷酸酶1以改善阿尔茨海默病和Tau病变
Yue Xiao,Linyu Wei,Jingfen Su et al.
Yue Xiao et al.
Abnormal accumulation of hyperphosphorylated tau (pTau) is a major cause of neurodegeneration in Alzheimer's disease (AD) and related tauopathies. Therefore, reducing pTau holds therapeutic promise for these diseases. Here, we developed a c...
Small molecules targeting selective PCK1 and PGC-1α lysine acetylation cause anti-diabetic action through increased lactate oxidation [0.03%]
靶向PCK1和PGC-1αlysine乙酰化的小分子通过增加乳酸氧化产生抗糖尿病作用
Beste Mutlu,Kfir Sharabi,Jee Hyung Sohn et al.
Beste Mutlu et al.
Small molecules selectively inducing peroxisome proliferator-activated receptor-gamma coactivator (PGC)-1α acetylation and inhibiting glucagon-dependent gluconeogenesis causing anti-diabetic effects have been identified. However, how these...
Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas [0.03%]
来源于假单胞菌的非经典C16萜类化合物的发现及生物合成研究
Xu-Hua Mo,Qing-Yin Pu,Tilo Lübken et al.
Xu-Hua Mo et al.
Biosynthesis of sodorifen with a unique C16-bicyclo[3.2.1]octene framework requires an S-adenosyl methionine-dependent methyltransferase SodC and terpene cyclase SodD. While bioinformatic analyses reveal a wide distribution of the sodCD gen...