Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response [0.03%]
Src激酶的时变活化决定内皮通透性反应
Jennifer E Klomp,Mark Shaaya,Jacob Matsche et al.
Jennifer E Klomp et al.
In the current model of endothelial barrier regulation, the tyrosine kinase SRC is purported to induce disassembly of endothelial adherens junctions (AJs) via phosphorylation of VE cadherin, and thereby increase junctional permeability. Her...
Targeted Degradation of a Hypoxia-Associated Non-coding RNA Enhances the Selectivity of a Small Molecule Interacting with RNA [0.03%]
靶向降解一种与缺氧相关的非编码RNA可增强小分子与其结合的选择性
Matthew G Costales,Blessy Suresh,Kamalakannan Vishnu et al.
Matthew G Costales et al.
Small-molecule targeted recruitment of nucleases to RNA is a powerful method to affect RNA biology. Inforna, a sequence-based design approach to target RNA, enables the design of small molecules that bind to and cleave RNA in a selective an...
Parvifoline AA Promotes Susceptibility of Hepatocarcinoma to Natural Killer Cell-Mediated Cytolysis by Targeting Peroxiredoxin [0.03%]
大黄素通过靶向过氧化物酶促进肝癌细胞的自然杀伤细胞介导的溶解作用
Huifang Zhu,Bin Wang,Lingmei Kong et al.
Huifang Zhu et al.
Natural killer (NK) cells play a crucial role in the surveillance of malignant cells. The engagement of NK group 2 member D (NKG2D) receptor with its ligands on target cells represents a promising therapeutic strategy against cancers. Here,...
Diacylglycerol Lipase-β Is Required for TNF-α Response but Not CD8+ T Cell Priming Capacity of Dendritic Cells [0.03%]
二酰基甘油脂酶-β对于树突状细胞的肿瘤坏死因子-α反应是必需的，但不是CD8⁺T细胞启动能力所必需
Myungsun Shin,Andrew Buckner,Jessica Prince et al.
Myungsun Shin et al.
Diacylglycerol lipase-β (DAGLβ) hydrolyzes arachidonic acid (AA)-esterified diacylglycerols to produce 2-arachidonoylglycerol (2-AG) and downstream prostanoids that mediate inflammatory responses of macrophages. Here, we utilized DAGL-tai...
Quantitative Interactome Proteomics Reveals a Molecular Basis for ATF6-Dependent Regulation of a Destabilized Amyloidogenic Protein [0.03%]
定量互作蛋白质组学揭示了ATF6调控不稳定的淀粉样蛋白基因的分子机制
Lars Plate,Bibiana Rius,Bianca Nguyen et al.
Lars Plate et al.
Activation of the unfolded protein response (UPR)-associated transcription factor ATF6 has emerged as a promising strategy to reduce the secretion and subsequent toxic aggregation of destabilized, amyloidogenic proteins implicated in system...
Vaccination with Tumor-Ganglioside Glycomimetics Activates a Selective Immunity that Affords Cancer Therapy [0.03%]
肿瘤神经节苷脂糖模拟物疫苗激活选择性免疫以治疗癌症
Wenyong Tong,Mario Maira,Rajarshi Roychoudhury et al.
Wenyong Tong et al.
Immune targeting of (glyco)protein tumor markers has been useful to develop cancer and virus vaccines. However, the ganglioside family of tumor-associated glycolipids remains intractable to vaccine approaches. Here we show that synthetic an...
Junmei Yi,Alexander M Minikes,Xuejun Jiang
Junmei Yi
Induction of ferroptosis has emerged as a potential cancer therapeutic approach. In this issue of Cell Chemical Biology, Zhang et al. (2019) demonstrate the anticancer efficacy and safety of the ferroptosis inducer imidazole ketone erastin ...
Charles H Williams,Charles C Hong
Charles H Williams
While the wound healing property of the macrolide FK506 is well known, the underlying mechanism has been elusive. In this issue of Cell Chemical Biology, Peiffer et al. (2019) utilize FKBP12 ligand to demonstrate that wound healing effects ...
Roman Meledin,Ashraf Brik
Roman Meledin
Preparation of proteins composed entirely of D-amino acids is an elegant approach to assemble completely orthogonal living systems. In this issue of Cell Chemical Biology, Weidmann et al. (2019) demonstrate the chemical synthesis and charac...
Keith E Maier,Christopher P Rusconi,Matthew Levy
Keith E Maier
PEGylation is a common modulator of pharmacokinetics for therapeutic agents in vivo. In this issue of Cell Chemical Biology, Moreno et al. (2019) show anti-PEG antibodies may directly inhibit the activity of a PEGylated aptamer, RB006, both...