Sulfondiimidamides unlocked as new S(VI) hubs for synthesis and drug discovery [0.03%]
硫磺二咪唑酰胺作为合成和药物发现中新类型的S（VI）中心被解锁
Nicholas D Ball
Nicholas D Ball
Despite their promise as drug targets, access to nitrogen-rich S(VI) compounds has been a significant synthetic challenge. In this issue of Chem, Zhang and Willis explore a new class of S(VI) compounds-sulfondiimidamides-providing robust st...
Titanium Radical Redox Catalysis: Recent Innovations in Catalysts, Reactions, and Modes of Activation [0.03%]
钛类自由基氧化还原催化：催化剂、反应及活化方式的最新进展
Xiangyu Wu,Yejin Chang,Song Lin
Xiangyu Wu
Radical chemistry has emerged as a cornerstone in modern organic synthesis, providing chemists with numerous new tools to rapidly expand reactivity and chemical space in academic and industrial research. In this regard, titanium complexes h...
Bioorthogonal Click and Release: A General, Rapid, Chemically Revertible Bioconjugation Strategy Employing Enamine N-oxides [0.03%]
生物正交点击与释放：利用亚胺烯胺N-氧化物的通用、快速和化学可逆的生物连接策略
Dahye Kang,Sanghyeon Lee,Justin Kim
Dahye Kang
A chemically revertible bioconjugation strategy featuring a new bioorthogonal dissociative reaction employing enamine N-oxides is described. The reaction is rapid, complete, directional, traceless, and displays a broad substrate scope. Reac...
Ternary host-guest complexes with rapid exchange kinetics and photoswitchable fluorescence [0.03%]
具有快速交换动力学和光切换荧光的三元主客体复合物
Julius Gemen,Michał J Białek,Miri Kazes et al.
Julius Gemen et al.
Confinement within molecular cages can dramatically modify the physicochemical properties of the encapsulated guest molecules, but such host-guest complexes have mainly been studied in a static context. Combining confinement effects with fa...
Alexander Ryabchun,Dhanya Babu,Jacopo Movilli et al.
Alexander Ryabchun et al.
Microscopic motility is a property that emerges from systems of interacting molecules. Unraveling the mechanisms underlying such motion requires coupling the chemistry of molecules with physical processes that operate at larger length scale...
Selective cellular probes for mammalian thioredoxin reductase TrxR1: rational design of RX1, a modular 1,2-thiaselenane redox probe [0.03%]
用于哺乳动物硫氧还蛋白还原酶TrxR1的选择性细胞探针：RX1模块化1，2-噻亚塞烯氧化还原探针的合理设计
Lukas Zeisel,Jan G Felber,Karoline C Scholzen et al.
Lukas Zeisel et al.
Quantifying the activity of key cellular redox players is crucial for understanding physiological homeostasis, and for targeting their perturbed states in pathologies including cancer and inflammatory diseases. However, cellularly-selective...
Accelerating PERx reaction enables covalent nanobodies for potent neutralization of SARS-CoV-2 and variants [0.03%]
加速PERx反应可有效使纳米抗体共价强力中和SARS-CoV-2及其变异体
Bingchen Yu,Shanshan Li,Takako Tabata et al.
Bingchen Yu et al.
The long-lasting COVID-19 pandemic and increasing SARS-CoV-2 variants demand effective drugs for prophylactics and treatment. Protein-based biologics offer high specificity, yet their noncovalent interactions often lead to drug dissociation...
Senjie Ma,Yumeng Xi,Haoyu Fan et al.
Senjie Ma et al.
Asymmetric alkene hydroamination could be a direct route to valuable chiral amines from abundant feedstocks. However, most asymmetric hydroaminations have limited synthetic value because they require a large excess of alkene, occur with mod...
Jianbo Liu,Matthew F L Parker,Sinan Wang et al.
Jianbo Liu et al.
Found in biomolecules, pharmaceuticals, and agrochemicals, amide-containing molecules are ubiquitous in nature, and their derivatization represents a significant methodological goal in fluorine chemistry. Trifluoromethyl amides have emerged...
Aza-Heterocycles via Copper-Catalyzed, Remote C-H Desaturation of Amines [0.03%]
远程C-H不饱和化胺类化合物aza-杂环的合成铜催化脱氢反应
Leah M Stateman,Ross M Dare,Alyson N Paneque et al.
Leah M Stateman et al.
The majority of medicines contain a nitrogen atom within a five- or six- membered ring. To rapidly access both such aza-heterocycles, we sought to develop a remote C-H desaturation of amines. Inspired by the Hofmann-Löffler-Freytag synthes...