Influence of structural moieties in squaraine dyes on optoacoustic signal shape and intensity [0.03%]
squaraine染料的结构基团对其光声信号强度和形状的影响研究
William M MacCuaig,Carly Wickizer,Richard S Van et al.
William M MacCuaig et al.
Optoacoustic imaging has grown in clinical relevance due to inherent advantages in sensitivity, resolution, and imaging depth, but the development of contrast agents is lacking. This study assesses the influence of structural features of sq...
Surached Siriwongsup,Anna M Schmoker,Scott B Ficarro et al.
Surached Siriwongsup et al.
A target identification platform derived from the bioorthogonal activation of reactive species is described. We explore the reactivity of halogenated enamine N-oxides and report that the previously undisclosed α,γ-halogenated enamine N-ox...
Connecting single-nucleotide polymorphisms, glycosylation status, and interactions of plasma serine protease inhibitors [0.03%]
连接单核苷酸多态性，糖基化状态以及血浆丝氨酸蛋白酶抑制物的相互作用
Di Wu,Manman Guo,Carol V Robinson
Di Wu
Understanding the combined impacts of genetic variances and post-translational modifications requires new approaches. Here, we delineate proteoforms of plasma serine protease inhibitors and relate specific proteoforms to their interactions ...
Merging Excited-State Copper Catalysis and Triplet Nitro(hetero)arenes for Direct Synthesis of 2-Aminophenol Derivatives [0.03%]
激发态铜催化和三重态硝基(杂)芳烃的结合用于直接合成2-氨基酚衍生物
Jagrut A Shah,Arghya Banerjee,Upasana Mukherjee et al.
Jagrut A Shah et al.
Nitro(hetero)arene derivatives are essential commodity chemicals used in various products, such as drugs, polymers, and agrochemicals. In this study, we leverage the excited-state reactivities of copper catalysts and nitro(hetero)arenes, an...
Miniaturized enantioselective tubular devices for the electromechanical wireless separation of chiral analytes [0.03%]
用于手性分析物的电磁无线分离的小型化旋光选择性管状器件
Sara Grecchi,Gerardo Salinas,Roberto Cirilli et al.
Sara Grecchi et al.
Chirality plays a crucial role in different research fields, ranging from fundamental physico-chemistry to applied aspects in materials science and medicine. In this context, enantioselective loading and pumping of chiral analytes for analy...
Covalent bicyclization of protein complexes yields durable quaternary structures [0.03%]
蛋白质复合物的共价双环化产生稳定的四级结构
George H Hutchins,Sebastian Kiehstaller,Pascal Poc et al.
George H Hutchins et al.
Proteins are essential biomolecules and central to biotechnological applications. In many cases, assembly into higher-order structures is a prerequisite for protein function. Under conditions relevant for applications, protein integrity is ...
New Mode of Asymmetric Induction for Enantioselective Radical N-Heterobicyclization via Kinetically Stable Chiral Radical Center [0.03%]
通过动力学稳定的手性自由基中心对映选择性地进行不对称诱导的自由基氮杂双环化反应的新模式
Hao Xu,Duo-Sheng Wang,Zhenyu Zhu et al.
Hao Xu et al.
Enantioselective radical N-heterobicyclization of N-allylsulfamoyl azides have been developed via metalloradical catalysis (MRC). The Co(II)-based catalytic system can homolytically activate the organic azides with varied electronic and ste...
Water-soluble chromenylium dyes for shortwave infrared imaging in mice [0.03%]
用于小鼠短波红外成像的水溶性色烯正离子染料
Shang Jia,Eric Y Lin,Emily B Mobley et al.
Shang Jia et al.
In vivo imaging using shortwave infrared light (SWIR, 1000-2000 nm) benefits from deeper penetration and higher resolution compared to using visible and near-infrared wavelengths. However, the development of biocompatible SWIR contrast agen...
Regioselective Crossed Aldol Reactions under Mild Conditions via Synergistic Gold-Iron Catalysis [0.03%]
通过协同金铁催化在温和条件下进行区域选择性交叉缩合反应
Teng Yuan,Xiaohan Ye,Pengyi Zhao et al.
Teng Yuan et al.
A synergistic gold/iron catalytic system was developed for sequential alkyne hydration and vinyl gold addition to aldehydes or ketones. Fe(acac)3 was identified as an essential co-catalyst in preventing vinyl gold protodeauration and facili...
Synthetic Na+/K+ exchangers promote apoptosis by disturbing cellular cation homeostasis [0.03%]
合成的Na+/K+交换因子通过干扰细胞内的阳离子稳态来促进细胞凋亡
Sang-Hyun Park,Inhong Hwang,Daniel A McNaughton et al.
Sang-Hyun Park et al.
A number of artificial cation ionophores (or transporters) have been developed for basic research and biomedical applications. However, their mechanisms of action and the putative correlations between changes in intracellular cation concent...