Nanoscale Metal-Organic Framework Mediates Radical Therapy to Enhance Cancer Immunotherapy [0.03%]
纳米金属有机骨架介导自由基疗法增强癌症免疫治疗
Kaiyuan Ni,Theint Aung,Shuyi Li et al.
Kaiyuan Ni et al.
Checkpoint blockade immunotherapy (CBI) elicits durable therapeutic responses by blocking T cell inhibitory pathways of tumors with pre-infiltrated T cells and/or high mutational burden to activate antitumor immunity but is ineffective agai...
Nanoscale Metal-Organic Framework Mediates Radical Therapy to Enhance Cancer Immunotherapy [0.03%]
纳米金属有机框架介导自由基疗法以增强癌症免疫治疗
Kaiyuan Ni,Theint Aung,Shuyi Li et al.
Kaiyuan Ni et al.
Checkpoint blockade immunotherapy (CBI) elicits durable therapeutic responses by blocking T cell inhibitory pathways of tumors with pre-infiltrated T cells and/or high mutational burden to activate antitumor immunity but is ineffective agai...
Correction: Charge Transfer between [4Fe4S] Proteins and DNA Is Unidirectional: Implications for Biomolecular Signaling [0.03%]
纠正：[4Fe4S]蛋白和DNA之间的电荷转移是单向的：对生物分子信号传导的意义
Ruijie D Teo,Benjamin J G Rousseau,Elizabeth R Smithwick et al.
Ruijie D Teo et al.
[This corrects the article PMC6350243.].
Published Erratum
Chem. 2019 Jun 13;5(6):1682-1684. DOI:10.1016/j.chempr.2019.05.016 2019
An Auxiliary Approach for the Stereoselective Synthesis of Topologically Chiral Catenanes [0.03%]
一类拓扑手性链烷烃的立体选择性合成辅助方法研究
Mathieu Denis,James E M Lewis,Florian Modicom et al.
Mathieu Denis et al.
Catenanes, molecules in which two rings are threaded through one another like links in a chain, can form as two structures related like an object and its mirror image but otherwise identical if the individual rings lack bilateral symmetry. ...
Merging Photoredox PCET with Nickel-Catalyzed Cross-Coupling: Cascade Amidoarylation of Unactivated Olefins [0.03%]
光红氧化PCET与镍催化交叉偶联结合：未活化烯烃的连续氨杂芳基化反应
Shuai Zheng,Álvaro Gutiérrez-Bonet,Gary A Molander
Shuai Zheng
The integration of amidyl radicals with cross-coupling chemistry opens new venues for reaction design. However, the lack of efficient methods for the generation of such radical species has prevented many such transformations from being brou...
Site-Selective C-H Functionalization of (Hetero)Arenes via Transient, Non-Symmetric Iodanes [0.03%]
通过瞬时不对称碘化试剂对芳烃和杂芳烃进行位点选择性C-H活化官能团化反应
Stacy C Fosu,Chido M Hambira,Andrew D Chen et al.
Stacy C Fosu et al.
A strategy for C-H functionalization of arenes and heteroarenes has been developed to allow site-selective incorporation of various anions, including Cl, Br, OMs, OTs, and OTf. This approach is enabled by in situ generation of reactive, non...
Gold-Catalyzed Oxidative Coupling of Alkynes toward the Synthesis of Cyclic Conjugated Diynes [0.03%]
金催化炔烃氧化偶联反应合成环状共轭二炔化合物
Xiaohan Ye,Haihui Peng,Chiyu Wei et al.
Xiaohan Ye et al.
A gold-catalyzed oxidative coupling of alkynes was developed as an efficient approach for the synthesis of challenging cyclic conjugated diynes (CCD). Compared to the classical copper-promoted oxidative coupling reaction of alkynes, this go...
Providing a New Aniline Bioisostere through the Photochemical Production of 1-Aminonorbornanes [0.03%]
通过光化学生产1-氨基降冰片烷提供新的苯胺生物异构体
Daryl Staveness,Taylor M Sodano,Kangjun Li et al.
Daryl Staveness et al.
This report describes the photochemical conversion of aminocyclopropanes into 1-aminonorbornanes via formal [3+2] cycloadditions initiated by homolytic fragmentation of amine radical cation intermediates. Aligning with the modern movement t...
Molecular Control of Internal Crystallization and Photocatalytic Function in Supramolecular Nanostructures [0.03%]
超分子纳米结构的内部分子调控及光催化功能研究
Roman V Kazantsev,Adam Dannenhoffer,Taner Aytun et al.
Roman V Kazantsev et al.
Supramolecular light-absorbing nanostructures are useful building blocks for the design of next-generation artificial photosynthetic systems. Development of such systems requires a detailed understanding of how molecular packing influences ...
A Massively Parallel Selection of Small Molecule-RNA Motif Binding Partners Informs Design of an Antiviral from Sequence [0.03%]
从序列着手设计抗病毒药物的海量小型分子-RNA结合配体筛选实验
Jessica L Childs-Disney,Tuan Tran,Balayeshwanth R Vummidi et al.
Jessica L Childs-Disney et al.
Many RNAs cause disease; however, RNA is rarely exploited as a small-molecule drug target. Our programmatic focus is to define privileged RNA motif small-molecule interactions to enable the rational design of compounds that modulate RNA bio...