Chiral piperidines from acyclic amines via enantioselective, radical-mediated δ C-H cyanation [0.03%]
通过立体选择性、自由基介导的δ碳氢氰化反应从无环胺制备手性哌啶
Zuxiao Zhang,Xin Zhang,David A Nagib
Zuxiao Zhang
Piperidines are the most prevalent heterocycle found in medicines. Yet, while they are often chiral, there remain no robust methods for their asymmetric syntheses. To solve this challenge, we have interrupted the century-old Hofmann-Löffle...
Xin Mu,Jonathan C Axtell,Nicholas A Bernier et al.
Xin Mu et al.
A cornerstone of modern synthetic chemistry rests on the ability to manipulate the reactivity of a carbon center by rendering it either electrophilic or nucleophilic. However, accessing a similar reactivity spectrum with boron-based reagent...
Architectural Stabilization of a Gold(III) Catalyst in Metal-Organic Frameworks [0.03%]
金属有机框架中金(III)催化剂的结构稳定化
John S Lee,Eugene A Kapustin,Xiaokun Pei et al.
John S Lee et al.
Unimolecular decomposition pathways are challenging to address in transition-metal catalysis and have previously not been suppressed via incorporation into a solid support. Two robust metal-organic frameworks (IRMOF-10 and bio-MOF-100) are ...
Metallotexaphyrins as MRI-Active Catalytic Antioxidants for Neurodegenerative Disease: A Study on Alzheimer's Disease [0.03%]
金属 texaphyrin 类化合物作为磁共振成像活性催化型抗氧化剂用于神经退行性疾病的研究：阿兹海默症模型研究案例
James T Brewster nd,Gregory D Thiabaud,Peter Harvey et al.
James T Brewster nd et al.
The complex etiology of neurodegeneration continues to stifle efforts to develop effective therapeutics. New agents elucidating key pathways causing neurodegeneration might serve to increase our understanding and potentially lead to improve...
Expanding the materials space of DNA via organic-phase ring-opening metathesis polymerization [0.03%]
通过有机相开环易位聚合扩展DNA的材料空间
Xuyu Tan,Hao Lu,Yehui Sun et al.
Xuyu Tan et al.
Herein, we develop a facile route to bring DNA to the organic phase, which greatly expands the types of structures accessible using DNA macromonomers. Phosphotriester- and exocyclic amine-protected DNA was synthesized and further modified w...
Redox-Neutral ortho Functionalization of Aryl Boroxines via Palladium/Norbornene Cooperative Catalysis [0.03%]
钯/氮杂环烯共催化下芳基硼氧化物的红氧中性邻位官能团化反应
Renhe Li,Feipeng Liu,Guangbin Dong
Renhe Li
Palladium/norbornene (Pd/NBE) cooperative catalysis, also known as the Catellani reaction, has become an increasingly useful method for site-selective arene functionalization; however, certain constraints still exist due to its intrinsic me...
Mijin Kim,Xiaojian Wu,Geyou Ao et al.
Mijin Kim et al.
Organic color centers are an emergent class of quantum emitters that hold vast potential for applications in bioimaging, chemical sensing, and quantum information processing. Here, we show that these synthetic color centers follow interesti...
Zhaoqianqi Feng,Xiuguo Han,Huaimin Wang et al.
Zhaoqianqi Feng et al.
Alkaline phosphatases (ALP) contribute to immunosuppression in solid tumors, but they, unfortunately, are "undruggable". Here we report enzyme-instructed assembly of peptides for selectively inhibiting the tumors that overexpress ALP. We de...
Beyond Media Composition: Cell Plasma Membrane Disruptions by Graphene Oxide [0.03%]
石墨烯氧化物对细胞质膜的破坏作用超出介质结合效应
Chao Sun,David A Holowka,Barbara A Baird et al.
Chao Sun et al.
Heavy Pnictogenium Cations as Transmembrane Anion Transporters in Vesicles and Erythrocytes [0.03%]
基于重氮元素的带正电囊泡和红细胞跨膜离子运输器
Gyeongjin Park,Dakota J Brock,Jean-Philippe Pellois et al.
Gyeongjin Park et al.
Our work on the complexation of fluoride anions using group 15 Lewis acids has led us to investigate the use of these main group compounds as anion transporters. In this paper, we report on the anion transport properties of tetraarylstiboni...