Chiral piperidines from acyclic amines via enantioselective, radical-mediated δ C-H cyanation
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Piperidines are the most prevalent heterocycle found in medicines. Yet, while they are often chiral, there remain no robust methods for their asymmetric syntheses. To solve this challenge, we have interrupted the century-old Hofmann-Löffler-Freytag (HLF) reac... ...
