Aroxybutynin and atomoxetine (AD109) for the treatment of obstructive sleep apnea: Rationale, design and baseline characteristics of the phase 3 clinical trials [0.03%]
治疗阻塞性睡眠呼吸暂停的索吡布丁和阿托莫西汀（AD109）：III期临床试验的设计、原理及基线特征
Luigi Taranto-Montemurro,Sanjay R Patel,Patrick J Strollo Jr et al.
Luigi Taranto-Montemurro et al.
Introduction: Two key factors leading to obstructive sleep apnea (OSA) pathogenesis include relaxation of upper airway muscles at sleep onset and their insufficient reactivation during obstructive events. Medications that...
Consolato M Sergi,Howard D Sesso
Consolato M Sergi
Project Safe Guard-Trauma (PSG-T): Protocol for a randomized controlled trial of lethal means safety counseling to promote secure firearm storage among individuals with PTSD [0.03%]
安全守卫-创伤项目（PSG-T）：一项关于在患有创伤后应激障碍的个体中开展致命手段安全性指导以促进安全贮存火器的随机对照试验方案
Ian H Stanley,Julia Finn,Kathleen M Flarity et al.
Ian H Stanley et al.
Firearm injury is the most common suicide method. When firearms are stored in a non-secure manner (e.g., unlocked, loaded), risk for suicide may be elevated. Accordingly, clinical, public health, and firearm industry stakeholders recommend ...
Use of patient-reported outcomes version of the common terminology criteria for adverse events in oncology clinical trials [0.03%]
肿瘤临床试验中患者报告结果版本的不良事件通用术语标准的应用
Lauren Rogak,Jamie K Forschmiedt,Ethan Basch et al.
Lauren Rogak et al.
The Patient-Reported Outcomes version of the Common Terminology for Adverse Events® (PRO-CTCAE®) item library enables patient self-reporting of symptoms in cancer clinical trials. It was developed as a companion to CTCAE v4.0. The aim of ...
Tele Tai Chi for people aging with mobility disabilities: Novel methodology and structured adaptation approach [0.03%]
针对行动障碍的老年人的远程太极：新颖的方法学和结构化适应路径
Elena T Remillard,Tracy L Mitzner,Kara T Mumma
Elena T Remillard
Many people aging with mobility disabilities experience barriers engaging in exercise programs and social events in-person and could benefit from virtual programs that make participation more accessible. The Tele Tai Chi clinical trial is a...
Design and refinement of a clinical trial staffing model within the evolving landscape of oncology clinical trials [0.03%]
在不断变化的肿瘤学临床试验格局中设计和改进临床试验人员配置模型
Ellen Siglinsky,Hannah Phan,Silviya Meletath et al.
Ellen Siglinsky et al.
Background: Quantifying workload for clinical trial staff represents an ongoing challenge for healthcare facilities conducting cancer clinical trials. We developed and evaluated a staffing model designed to meet this need...
Reconstructing patient level survival data from published Kaplan-Meier curves [0.03%]
从发表的Kaplan-Meier曲线中重建患者水平的生存数据
Jaromme Kim,Prabhakar Chalise,Jianghua He
Jaromme Kim
Introduction: Individual-level patient data (IPD) are helpful for designing clinical trials, conducting meta-analyses, or methodology research. However, such patient level data are not readily available. Multiple methods ...
Peer delivered, emotion regulation-focused mental health prevention training for fire fighter trainees: Design and methodology of a randomized controlled trial [0.03%]
针对消防员学员的情绪调节重点型心理健康预防训练：随机对照试验的设计与方法学
Eric C Meyer,Todd Farchione,Nathan A Kimbrel et al.
Eric C Meyer et al.
Fire fighters (FFs) risk their lives, health, and well-being through trauma exposure and other occupational stressors. FFs report concerning rates of mental health challenges, alcohol use disorders, and suicide risk. These problems tend to ...
Study design and methods for the physical activity index (PAI) feasibility pilot trial for breast and colon cancer survivors in North Carolina [0.03%]
北卡罗来纳州乳腺癌和结直肠癌幸存者身体活动指数（PAI）可行性试点试验的研究设计与方法
Shirley M Bluethmann,Janet Tooze,Joni K Evans et al.
Shirley M Bluethmann et al.
The majority of the 18 million US adults with cancer history ("survivors") do not meet recommendations for obtaining regular physical activity (PA) or limiting sedentary behavior in their daily lives. Breast cancer survivors (BCS) and colon...
A randomized controlled trial protocol for evaluating the feasibility, acceptability, and work outcomes of individualized placement and support adapted for autistic adults in the community [0.03%]
个体化安置和支持服务模式改善社区孤独症成人就业的可行性和有效性的随机对照试验方案
Marjorie Solomon,Jo A Yon-Hernández,Steve Ruder et al.
Marjorie Solomon et al.
Relatively few autistic adults, including those with average intellectual abilities, are competitively employed, meaning that they hold jobs together with non-disabled workers and receive comparable wages and benefits. In California, for ex...