The design of a small Bayesian hybrid-controlled trial utilizing time-to-event data from six published sources that used best alternative care to treat liver-predominant metastasis from primary ocular melanoma [0.03%]
利用六项发表的研究中以最佳替代护理治疗原发性眼黑色素瘤肝转移患者生存时间数据的小型贝叶斯混合控制试验的设计
David Zahrieh,Xiaofei Wang,Svetomir N Markovic et al.
David Zahrieh et al.
Background: Time-to-event endpoints, such as progression-free survival (PFS), are used to evaluate clinical activity in early-phase RCTs in cancer research. Because the power to detect a reduction in the hazard rate depen...
A family navigator model for foster parents to promote youth mental health wellness: Study development and protocol [0.03%]
促进寄养儿童心理健康的家庭导航模型：研究开发与实施协议
Christina L Boisseau,Heather Risser,Miguel A Herrera et al.
Christina L Boisseau et al.
Background: Children in foster care experience disproportionately high rates of mental illness, yet most do not receive timely or evidence-based mental health treatment. Foster parents play a critical role in treatment en...
Evaluating the substitutability of fruit versus menthol and tobacco-flavored e-cigarettes on combustible cigarette cessation: Randomized clinical trial protocol [0.03%]
评估水果味电子烟替代薄荷味和烟草味电子烟帮助燃烧型卷烟戒烟的可替代性：随机临床试验方案
Olivia Klapec,Andrew A Strasser,E Paul Wileyto et al.
Olivia Klapec et al.
While regulations have restricted the sale of pod-style fruit-flavored e-cigarettes, observational and clinical data suggest that their use is associated with smoking cessation among adults. Surprisingly, no randomized clinical trials have ...
Expressive writing to reduce depressive and anxiety symptoms among sexual minority veterans: Study design for a pilot randomized controlled trial [0.03%]
表达性书写减少性少数派退伍军人的抑郁和焦虑症状：一项初步随机对照试验的研究设计
Kelly L Harper,Katherine Kelton,Nicholas A Livingston et al.
Kelly L Harper et al.
Background: Sexual minority veterans (e.g., gay, lesbian, bisexual) are at increased risk for depression and anxiety due in part to the experience of sexual minority stressors. However, few interventions target distress r...
LEARNER - A prospective, randomized controlled study to evaluate the effects of daily low dose aspirin in pregnant women with sickle cell disease when initiated at the first trimester versus the second trimester of the gestational period - study protocol [0.03%]
低剂量阿司匹林在妊娠早期和中期开始对镰状细胞病孕妇影响的前瞻性随机对照研究——研究方案
Miguel Brito,Catarina Ginete,Tatiana Gomes et al.
Miguel Brito et al.
Background: Pregnancy in women with Sickle Cell Disease (SCD) is associated with an increased risk in severe complications, such as eclampsia, pre-eclampsia, maternal death, intrauterine growth restrictions, perinatal mor...
Protocol for Neuro-Oncology Anywhere: Deploying Mayo Clinic's remote cognitive assessment battery and wearable device monitoring platform while assessing the impact of metformin on cognition and quality of life in patients with history of cranial radiation [0.03%]
远程神经肿瘤学协议：在评估既往接受过颅脑放射治疗的患者的二甲双胍对认知和生活质量的影响的同时部署梅奥诊所的认知评估量表和可穿戴设备监测平台
Ugur Sener,Bryan Neth,Taylor Galloway et al.
Ugur Sener et al.
Cognitive symptoms are among the most frequently reported issues in cancer patients treated with cranial radiation, yet they remain inadequately assessed in clinical practice and are suboptimally treated. Cranial radiation is an integral pa...
Development and feasibility testing of a PrEP uptake and adherence intervention for women with trauma-related mental health conditions: Protocol for a randomized controlled trial [0.03%]
一项针对患有与创伤相关的心理健康状况的女性提高暴露前预防措施依从性的干预的发展和可行性测试：随机对照试验方案
Angela M Heads,Kaixuan An,Mandy J Hill et al.
Angela M Heads et al.
Background: Experiencing trauma increases susceptibility to HIV among women in the Southern U.S, through factors such as condomless sex, coerced sex, and substance use. Despite the effectiveness of pre-exposure prophylaxi...
The use of memantine for prevention of Alzheimer's disease: Pilot feasibility study rationale and protocol [0.03%]
石杉碱甲预防阿尔茨海默病的发病机制、研究和协议设计：一项可行性研究
Anna M Arp,George S Bloom,Anelyssa D&#x;Abreu et al.
Anna M Arp et al.
Background: Alzheimer's disease (AD) affects over 6 million older adults in the Untiled States. Evidence suggests the neuropathology leading to the disorder begins decades earlier, calling for a preventative treatment tha...
Efficacy of Cognitively-based compassion training for Veterans with chronic pain with psychological Comorbidity: Protocol for a randomized clinical trial [0.03%]
基于认知的共情训练对心理合并症慢性疼痛退伍军人的有效性：随机临床试验方案
Anne Malaktaris,Niloofar Afari,Pollyanna Casmar et al.
Anne Malaktaris et al.
Chronic pain with psychological comorbidity, especially posttraumatic stress disorder (PTSD) and/or depression, is a prevalent and costly problem, especially among Veterans. Compassion meditation (CM) is a meditative practice that focuses o...
Clinical screening and peer interventions to prevent substance use in at-risk adolescents: A longitudinal single-arm trial protocol [0.03%]
高风险青少年物质使用筛查及同伴干预的纵向单组试验方案
Gail L Rose,Michelle Shepard,Derek Devine et al.
Gail L Rose et al.
Background: Mental health conditions and substance use disorders commonly co-occur and adolescence is a period of increased risk for both. Adolescents with mental health conditions often begin using substances earlier tha...