Enhancing uptake of the Canadian Prison Needle Exchange Program using a non-randomized stepped-wedge cluster type 1 hybrid implementation trial: The NEXUS study protocol [0.03%]
Olivia Price,Frederick L Altice,Lynn M Madden et al.
Olivia Price et al.
Background: Prison needle exchange programs (PNEPs) are evidence-based harm reduction interventions that decrease bloodborne virus transmission by reducing the sharing of injection equipment. Canada introduced PNEPs in ni...
Micro-UltraSound In Cancer - Active Surveillance (MUSIC-AS): A paired, prospective, non-inferiority trial comparing micro-ultrasound and multiparametric MRI at confirmatory biopsy [0.03%]
微型超声在癌症中的活性监测(MUSIC-AS)：微超声与确认活检多参数磁共振成像的配对前瞻性非劣效性试验
Oliver Little,Pat Albers,Tarek A Bismar et al.
Oliver Little et al.
Background: Accurate risk assessment is essential for men on active surveillance (AS) of prostate cancer (PCa). Multiparametric MRI improves detection of clinically significant PCa (csPCa; Grade Group ≥2) but is limited ...
Standardization of clinical trials subject ID schematics: A portfolio-wide model to enhance data integrity and regulatory compliance [0.03%]
临床试验受试者ID方案标准化：一种增强数据完整性和法规遵从性的全投资组合模型
Ananya Jain,Steve Demas,Todd Bazin
Ananya Jain
Background: Subject identification is a cornerstone of data integrity and regulatory compliance in clinical trials. Legacy, study-specific subject ID conventions may cause risk of duplication, hinder traceability of rescr...
Mechanistic study of inspiratory training in childhood Asthma: Rationale and methods of a pediatric clinical trial [0.03%]
儿童哮喘吸气训练临床试验的合理性及方法学研究机械机制探究
Dharini M Bhammar,Harrison N Jones,Tarig M Ali-Dinar et al.
Dharini M Bhammar et al.
Asthma is a common pediatric disease of the airways. Obesity among children increases the risk of asthma and is associated with a unique non-allergic asthma phenotype that is highly symptomatic and often unresponsive to conventional drugs. ...
Protocol for a pragmatic randomized controlled trial evaluating a care pathway incorporating ultrasound-guided platelet-rich plasma injection plus physiotherapy versus physiotherapy alone in patients with L5/S1 lumbar disc herniation [0.03%]
一项实用随机对照试验方案，评估超声引导下富含血小板的血浆注射联合物理疗法与单纯物理疗法治疗L5/S1腰椎间盘突出症患者的疗效差异
Rayhan Islam,Mahmudul Haque Udoy,Md Zahirul Islam et al.
Rayhan Islam et al.
Background: Lumbar disc herniation (LDH) causes low back pain and lower-limb neurological symptoms. Conservative and surgical treatments have similar outcomes and recurrence rates within two years. Anti-inflammatory drugs...
Addressing financial and health-related social needs among patients with cancer: Study protocol for CAN-ASSIST pilot clinical trial [0.03%]
针对癌症患者的财务和与健康相关的社会需求：CAN-ASSIST试点临床试验研究方案
Maedeh Sharifian,Victoria Nguyen,Aarushi Madan et al.
Maedeh Sharifian et al.
Background: Financial hardship and health-related social needs (HRSNs) are prevalent among cancer patients and contribute to disparities in outcomes. Addressing these issues can reduce harm, yet routine screening and inte...
Activating the vagus nerve-adrenal anti-inflammatory axis to delay aging: A randomized controlled trial protocol [0.03%]
迷走神经-肾上腺抗炎轴的激活以延缓衰老：一项随机对照试验方案
Chong Sun,Meihong Fu,Jiao Liu et al.
Chong Sun et al.
Background: Aging is a primary risk factor for chronic diseases, yet safe and effective interventions remain limited. Traditional Chinese Medicine (TCM) highlights the role of acupuncture in health preservation, with ST36...
E-health intervention in pregnant women exposed to intimate partner violence (eIPV): Results of a pilot randomised controlled trial [0.03%]
一项针对孕期遭受亲密伴侣暴力妇女的电子健康干预措施(eIPV)试点随机对照试验结果
Antonella Ludmila Zapata-Calvente,Aurora Bueno Cavanillas,Karen Andreasen et al.
Antonella Ludmila Zapata-Calvente et al.
Objective: To assess the feasibility of randomising a sufficiently large number of pregnant women who screen positive for intimate partner violence (IPV) to perform a full-scale effectiveness trial. ...
Diversity in clinical Trials: The example of systemic lupus erythematosus [0.03%]
临床试验的多样性：系统性红斑狼疮的例子
Andrew Bevan,Nora Carroll,Garrick Wallstrom et al.
Andrew Bevan et al.
Objective: The FDA requires clinical trials to reflect real-world diversity. Systemic lupus erythematosus (SLE) is a disease that disproportionately affects individuals of Black African descent that has not been assessed ...
Pooyan Khajehpour,Jonathan Amar,Krisda H Chaiyachati et al.
Pooyan Khajehpour et al.
Persistent under-representation of certain racial, ethnic, or socio-demographic subgroups in clinical studies continues to put patients at risk for unfavorable health outcomes. In an environment where accrual increasingly relies on digital ...