Electronic clinical outcome assessments and the European Union's clinical trial regulation: Smoothing the path to friction? [0.03%]
电子临床结果评估与欧盟临床试验条例：通向摩擦之路？
Pierre Mermet-Bouvier,Pierre-Frederic Omnes,Valdo Arnera et al.
Pierre Mermet-Bouvier et al.
The European Union's Clinical Trial Regulation 536/2014 (EU-CTR) sought to harmonize clinical trial rules, ensure high standards of safety, and streamline processes through its new Clinical Trials Information System (CTIS). However, confusi...
Tobacco cessation intervention for individuals with severe mental illness in Bangladesh, India, and Pakistan: protocol for a multi-country feasibility randomised controlled trial (SCIMITAR-SA) [0.03%]
孟加拉国、印度和巴基斯坦严重精神疾病患者戒烟干预方案：可行性随机对照试验（SCIMITAR-SA）多国研究方案
Garima Bhatt,Kousar Ishaq,Aatik Arsh et al.
Garima Bhatt et al.
Background: Tobacco is consumed by two-thirds of individuals with severe mental illness (SMI). Despite a high tobacco-related disease burden, there is a lack of evidence-based cessation interventions for individuals with ...
Protocol for a pragmatic trial comparing navigator and automated virtual interventions for guaranteeing adherence to fecal immunochemical testing (NAVIGATE-FIT) [0.03%]
关于比较导航和自动化虚拟干预措施以保证粪便免疫化学检测依从性的务实试验方案(.navigator-fit试验)
Emily Jansen,Divya A Shankar,Tabitha Cherilus et al.
Emily Jansen et al.
Background: Fecal immunochemical testing (FIT) - a non-invasive colorectal cancer (CRC) screening method offers an opportunity to bridge CRC screening gaps in underserved settings. The effectiveness of FIT as a screening ...
The effects of high-protein vs conventional protein enteral nutrition on intestinal permeability, severity of disease, and mortality in critically ill intensive care unit Patients: Protocol for a randomized controlled trial [0.03%]
高蛋白肠内营养与常规蛋白肠内营养对重症监护室危重病人肠道通透性、疾病严重程度及死亡率影响的随机对照试验方案：一项随机对照试验方案协议
Shonaz Ahmadikhatir,Pardis Irandoost,Omid Moradi Moghaddam et al.
Shonaz Ahmadikhatir et al.
Background: Intestinal permeability is an important determinant in intensive care unit patients. Enteral nutrition is vital for nutritional supplementation in critically ill ICU patients. The amount of Enteral nutrition p...
Effectiveness of transoral robotic surgery of the base of the tongue vs. conservative treatment for obstructive sleep apnea, a RCT, the RAPID study protocol [0.03%]
经口机器人手术治疗阻塞性睡眠呼吸暂停的疗效与保守治疗方法比较：RAPID研究方案
A G L Toppenberg,J van der Maten,M Bos et al.
A G L Toppenberg et al.
Background: CPAP is the gold standard treatment for obstructive sleep apnea (OSA) but suffers from poor long-term compliance. Alternatives like mandibular advancement devices (MADs) and surgery, such as transoral robotic ...
Evaluation of a trauma center-based, technology enhanced stepped care intervention to promote the mental health recovery of adolescent traumatic injury survivors [0.03%]
基于创伤中心的技术增强式分阶段照护干预措施在促进青少年损伤幸存者精神健康康复方面的评价研究
Tatiana M Davidson,Theresa Skojec,Priscilla Li et al.
Tatiana M Davidson et al.
Background: Pediatric traumatic injury (PTI) is a leading cause of hospitalization and long-term morbidity among U.S. youth, with approximately 30% developing posttraumatic stress or depression. Despite clear mandates fro...
The HEART-GP strategy for ruling out acute coronary syndrome in out-of-hours primary care: a diagnostic accuracy trial protocol [0.03%]
用于在非工作时间基层医疗中排除急性冠脉综合征的HEART-GP策略诊断准确性试验方案
Indra M B Melessen,Jelle C L Himmelreich,Amy Manten et al.
Indra M B Melessen et al.
Background: Acute coronary syndrome (ACS) is a life-threatening condition that requires rapid identification to prevent morbidity and mortality. Differentiating ACS from benign conditions remains difficult in out-of-hours...
IGROOVE: Protocol for a randomized, controlled, single-blind trial of dance intervention in older adults with subjective cognitive decline [0.03%]
IGROOVE：在老年人中主观认知下降的舞蹈干预随机对照单盲试验方案
Ayse Uneri,Jason T Fanning,John R Beck et al.
Ayse Uneri et al.
Background: Accumulating evidence supports the importance of physical activity for maintaining or improving cognitive and cardiovascular health. Dance movement has been emerging as a form of physical activity that may pro...
Clinical efficacy of Xiaotan Sanjie decoction in treating gastric cancer with peritoneal metastases: A study protocol for a randomized controlled trial [0.03%]
消痰散结汤治疗胃癌腹腔转移的临床疗效观察——随机对照试验方案研究
Quan-Yao Li,Xi Li,Hui Liu et al.
Quan-Yao Li et al.
Background: Gastric cancer (GC) is a highly prevalent malignancy worldwide. Approximately 20%-43% of patients present with peritoneal metastasis (PM) at initial diagnosis, resulting in a 5-year survival rate of less than ...
Adjusting for intercurrent events using Bayesian joint models for longitudinal outcomes in clinical trials [0.03%]
基于临床试验纵向结果的贝叶斯联合模型在调整偶发事件中的应用
Wen Teng,Yongdong Ouyang,Jose Dianti et al.
Wen Teng et al.
Background: Intercurrent events in clinical trials can disrupt the interpretation and/or measurement of clinical endpoints. This article focuses on terminal intercurrent events that preclude complete measurement of a long...