Evaluating a negotiation training program for family caregivers of older people using a Multiphase Optimization Strategy (MOST) design and protocol [0.03%]
使用多阶段优化策略(MOST)设计和方案评估老年人家庭护理人员的谈判培训项目
Charlie Olvera,Vanessa Ramirez-Zohfeld,Alaine Murawski et al.
Charlie Olvera et al.
Traditional clinical trial designs such as the isolated two-arm randomized controlled trial (RCT) do not offer robust solutions for evaluating and optimizing delivery of complex, multi-component behavioral interventions. A recent alternativ...
Healthy eating and active living to reverse diabetes (HEAL Diabetes-USA): a randomized controlled pilot study protocol to assess the feasibility of a weight loss intervention for diabetes remission [0.03%]
健康饮食与积极生活逆转糖尿病（HEAL糖尿病-美国）：评估针对糖尿病缓解的减重干预措施可行性的随机对照试点研究方案
Alexandria M Boykins,Asos Mahmood,Mona N Wicks et al.
Alexandria M Boykins et al.
Background: Intensive lifestyle programs promoting weight loss have been shown to induce long-term remission of early Type 2 diabetes (T2D). Further, multicomponent weight loss interventions are recommended for all patien...
A mechanistic trial of the neurobiology of extinction learning and intraparietal sulcus stimulation: Protocol [0.03%]
关于消退学习和内侧顶叶沟刺激的神经生物学机制试验：方案
Sonalee A Joshi,Tao Lin,Nicholas L Balderston et al.
Sonalee A Joshi et al.
Post-traumatic stress disorder (PTSD) links to impaired extinction learning post-trauma. While treatments like prolonged exposure therapy improve this learning, they benefit only 40-60 % of patients. Optimal arousal supports extinction lear...
MiBUP: A pilot randomized controlled trial of low-dose initiation of buprenorphine for opioid use disorder: Design and rationale [0.03%]
低剂量丁丙诺啡治疗阿片类药物使用障碍的试点随机对照试验（MI-BUP项目）：设计与原理
Benjamin T Hayes,Annika Sabado,Haruka Minami et al.
Benjamin T Hayes et al.
Background: Buprenorphine is an effective treatment for opioid use disorder (OUD), however withdrawal during initiation is a barrier. Low-dose initiation (LDI) involves starting very small doses of buprenorphine overlappi...
Protocol for neuro-oncology anywhere 242: Pilot study evaluating telehealth and in-person assessments in patients with glioma receiving oral chemotherapy [0.03%]
胶质瘤口服化疗患者的远程医疗和现场评估试点研究协议：任何地点神经肿瘤学协议242
Ugur Sener,Taylor Galloway,Bryan Neth et al.
Ugur Sener et al.
Care at high volume centers is associated with an overall survival benefit for patients with glioma. However, access to these centers is challenging for patients who experience neurologic deficits, leading to loss of independence and render...
Type I error control and interim monitoring for co-primary hypotheses involving a subgroup in the Outpatient Treatment with Anti-Coronavirus Immunoglobulin (OTAC) trial [0.03%]
门诊抗冠状病毒免疫球蛋白治疗（OTAC）试验中主要亚组假设的I类错误控制和期中监控
Jiayi Hu,Abdel G Babiker,Cavan S Reilly et al.
Jiayi Hu et al.
The recent growth of immunoglobulin-based therapies has motivated clinical trials testing primary endpoints both in the overall cohort and in subgroups of patients, such as in patients without specific antibodies at baseline. Multiple testi...
Effectiveness of hippotherapy on balance performance, neurophysiological parameters and clinical symptoms of multiple sclerosis: Study protocol of a randomized controlled multicenter study (MS-HIPPO II - Movement in Balance) [0.03%]
马术疗法对多发性硬化患者平衡能力、神经生理参数和临床症状的效果：一项随机对照多中心研究（MS-HIPPO II-平衡中的运动）的试验方案
Isabel Stolz,Leonard Braunsmann,Franca Rosiny et al.
Isabel Stolz et al.
Background: Exercise and physical therapy have been shown to be effective in the non-pharmacological symptomatic treatment of multiple sclerosis (MS). Hippotherapy as an additive physical therapy intervention is applied i...
Strategic risk assessment in oncology: Utilizing single-agent activity to boost combination therapy approvals [0.03%]
肿瘤学中的战略风险评估：利用单药活性促进联合疗法审批
Adetayo Kasim,Marina Anastasiou,Evangelia Loizou et al.
Adetayo Kasim et al.
Background: This study examines whether single-agent activity in early clinical phases correlates with the approval likelihood of combination therapies in oncology. Using the Intelligencia AI database, we investigated the...
Exploring the efficacy and safety of Antitoxin and Antipyretic Decoction in treating acute respiratory viral infections with Wind-Heat Obstruction of the Exterior and Heat Invading the Lung Defense a study protocol for a randomized controlled trial [0.03%]
解表化热汤治疗外有风热、卫闭肺郁证急性呼吸道病毒感染有效性和安全性的临床试验方案
Wen-Han Li,Dong-Chen Xu,Xi-Yue Lu et al.
Wen-Han Li et al.
Background: Acute respiratory viral infections are the most common diseases affecting the respiratory system. Currently, there is still a lack of specific antiviral drugs targeting various viruses. Traditional Chinese her...
Study of Chemosensory Enhancement through Neuromodulation Training (SCENT): Design and methodology of a randomized clinical trial for COVID-related persistent smell dysfunction [0.03%]
COVID-19相关持续性嗅觉障碍神经调节训练改善化学感觉功能研究（SCENT）的设计与方法学：一项随机对照试验
Nicole Cash,Mary Clare Koebel,Bashar W Badran et al.
Nicole Cash et al.
Background: Few evidence-based treatments exist for COVID-related persistent smell dysfunction. While smell/olfactory training (ST) has emerged as a widely prescribed, first line treatment, rigorous study is required to d...