Feasibility and acceptability of testing a menstrual-cycle timed smoking cessation intervention for women of reproductive age (Project Phase): Protocol of a pilot randomized controlled trial [0.03%]
针对育龄妇女进行月经周期戒烟干预试点随机对照试验的可行性和可接受性：项目阶段研究方案
Uma S Nair,Elizabeth S Miller,Melanie L Bell et al.
Uma S Nair et al.
Background: Compared to men, women have unique barriers to smoking cessation and are less likely to utilize quitline services. While current clinical recommendations have called for sex/gender-specific smoking cessation p...
Primary Palliative Care for Emergency Medicine (PRIM-ER): Applying form and function to a theory-based complex intervention [0.03%]
急诊医学的一线姑息治疗（PRIM-EM）：将基于理论的复杂干预措施应用于形式和功能
Jacob Hill,Allison M Cuthel,Philip Lin et al.
Jacob Hill et al.
Background: Emergency departments are seeing an increase in acute exacerbations of chronic disease in the older-adult population. The delivery of palliative care in the emergency department can increase goal-concordant ca...
Incomplete data analysis of non-inferiority clinical trials: Difference between binomial proportions case [0.03%]
非劣性临床试验不完全数据的统计分析：二项分布比例检验的情况
Yulia Sidi,Ofer Harel
Yulia Sidi
Background: Incomplete data analysis continues to be a major issue for non-inferiority clinical trials. Due to the steadily increasing use of non-inferiority study design, we believe this topic deserves an immediate atten...
Study within a trial (SWAT) protocol. Investigating the effect of personalised versus non-personalised study invitations on recruitment: An embedded randomised controlled recruitment trial [0.03%]
一项在临床试验中研究个性化和非个性化邀请对招募效果影响的方案嵌入式随机对照试验（SWAT）
Joanne Woodford,Kajsa Norbäck,Josefin Hagström et al.
Joanne Woodford et al.
Introduction: Recruitment into clinical trials is a common challenge experienced by healthcare researchers. Currently, there is little evidence regarding strategies to improve recruitment into clinical trials. However, pr...
Protocol and recruitment results from a 13-week randomized controlled trial comparing the effects of different doses of nitrate-rich beetroot juice on cognition, cerebral blood flow and peripheral vascular function in overweight and obese older people [0.03%]
高剂量与低剂量富含硝酸盐的甜菜根汁对超重和肥胖老年人认知、脑血流及外周血管功能影响的13周随机对照试验方案及入组结果
Abrar M Babateen,Sofia Rubele,Oliver Shannon et al.
Abrar M Babateen et al.
Background: Nitrate-rich food can increase NO production and may induce positive effects on brain function. This study examined the feasibility of a randomized clinical trial (RCT) testing the effects of prolonged consump...
Vladimir Bogin
Vladimir Bogin
A master protocol is a unifying study construct that includes multiple subgroups and substudies, with patients having same or different diseases and that employ one or multiple drugs to treat it. Initially designed for oncology, master prot...
A model-based approach for simulating adaptive clinical studies with surrogate endpoints used for interim decision-making [0.03%]
基于模型的适应性临床试验仿真方法及其在中期决策中使用替代终点的效果评估
Xiaotian Chen,Alan Hartford,Jun Zhao
Xiaotian Chen
In clinical trials, when exploring multiple dose groups to establish efficacy and safety on one or more selected doses, adaptive designs with interim dose selection are often used for dropping less effective dose groups. When it takes a lon...
Effectiveness and safety of intermittent preventive treatment for malaria using either dihydroartemisinin-piperaquine or artesunate-amodiaquine in reducing malaria related morbidities and improving cognitive ability in school-aged children in Tanzania: A study protocol for a controlled randomised trial [0.03%]
坦桑尼亚学龄儿童间歇性预防性治疗疟疾的有效性和安全性：一项使用双氢青蒿素-哌喹或艺术酸-氨酚喹采取控制随机试验的研 究方案
Geofrey Makenga,Vito Baraka,Filbert Francis et al.
Geofrey Makenga et al.
Background: In high transmission settings, up to 70% of school-aged children harbour malaria parasites without showing any clinical symptoms. Thus, epidemiologically, school aged children act as a substantial reservoir fo...
Electronic Monitoring Of Mom's Schedule (eMOMS™): Protocol for a feasibility randomized controlled trial to improve postpartum weight, blood sugars, and breastfeeding among high BMI women [0.03%]
电子监控母亲时间表（eMOMS）：一项可行性随机对照试验的方案，旨在通过提高高体重指数女性的产后体重、血糖和母乳喂养水平来改善预后指标
Lisette T Jacobson,Tracie C Collins,Meredith Lucas et al.
Lisette T Jacobson et al.
Background: Overweight and obesity are major risk factors for gestational diabetes among U.S. women. Evidence suggests that longer duration of breastfeeding among women with a history of gestational diabetes is associated...
Rationale and study design: A randomized controlled trial of early palliative care in newly diagnosed cancer patients in Addis Ababa, Ethiopia [0.03%]
埃塞俄比亚亚的斯亚贝巴新诊断癌症患者的早期姑息治疗随机对照试验的设计与研究方案
Eleanor Reid,Ephrem Abathun,Jilcha Diribi et al.
Eleanor Reid et al.
Patient-reported outcomes and economic aspects of Palliative Care (PC) provision in low-income countries (LIC) are under-studied. Demonstrating the economic value of PC is key to sustainability and guiding health care policy. Our preliminar...