Methylation of FAM110C is a synthetic lethal marker for ATR/CHK1 inhibitors in pancreatic cancer [0.03%]
FAM110C甲基化是胰腺癌中ATR/CHK1抑制剂的合成致死标志物
Fengna Liu,Aiai Gao,Meiying Zhang et al.
Fengna Liu et al.
Background and objectives: Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignancies. An epigenetic-based synthetic lethal strategy provides a novel opportunity for PDAC treatment. Finding more DNA dama...
Single photon emission computed tomography/computed tomography imaging of gouty arthritis: A new voice [0.03%]
单光子发射计算机断层成像/计算机断层成像技术在痛风性关节炎中的应用：新的视角
Yan Wang,Yan Zha,Lin Liu et al.
Yan Wang et al.
Gouty arthritis, often referred to simply as gout, is a disorder of purine metabolism characterized by the deposition of monosodium urate monohydrate (MSU) crystals in multiple systems and organs, especially in joints and their surrounding ...
Effects of metaraminol and norepinephrine on hemodynamics and kidney function in a miniature pig model of septic shock [0.03%]
麻黄碱和去甲肾上腺素对脓毒性休克迷你猪模型血流动力学及肾脏功能的影响
Xiaodan Li,Yi Bai,Ci Tian et al.
Xiaodan Li et al.
Objective: To compare the effects of metaraminol and norepinephrine on hemodynamics and kidney injury in the treatment of septic shock, and calculate the conversion dose ratio between the two vasopressors. ...
Distribution of the causes of fever of unknown origin in China, 2013-2022 [0.03%]
中国不明原因发热病因分布（2013-2022年）
Sihan Kang,Rui Zheng
Sihan Kang
Background and objectives: Fever of unknown origin (FUO) has long been a cause for concern among clinicians, and its spectrum has evolved with progress in medicine. This study aimed to investigate the distribution of caus...
Comparison of admission glycemic variability and glycosylated hemoglobin in predicting major adverse cardiac events among type 2 diabetes patients with heart failure following acute ST-segment elevation myocardial infarction [0.03%]
急性ST段抬高型心肌梗死合并心脏衰弱的2型糖尿病患者院内血糖波动和糖化血红蛋白预测不良心血管事件的比较研究
Xiuxiu Yang,Gong Su,Tao Zhang et al.
Xiuxiu Yang et al.
Background and objectives: Hyperglycemia is associated with adverse outcomes in patients with acute myocardial infarction (AMI) as well as in patients with heart failure. However, the significance of admission glycemic va...
Qimin Zheng,Xiangchen Gu,John Cijiang He et al.
Qimin Zheng et al.
Irbesartan ameliorates diabetic kidney injury in db/db mice by restoring circadian rhythm and cell cycle [0.03%]
厄贝沙坦通过恢复昼夜节律和细胞周期来改善db/db小鼠糖尿病肾脏损伤
Hailing Zhao,Zhiguo Li,Meihua Yan et al.
Hailing Zhao et al.
Background and objectives: Irbesartan has been widely used in the clinical treatment of diabetic kidney disease (DKD). However, the molecular mechanism of its delay of DKD disease progression has not been fully elucidated...
Insufficiency of quality of life as the treatment endpoint for balloon pulmonary angioplasty in inoperable chronic thromboembolic pulmonary hypertension [0.03%]
球囊肺动脉成形术治疗不可手术慢性血栓性肺高压疗效评估终点的局限性——生活质量指标不足
Juanni Gong,Yuan Ding,Jianfeng Wang et al.
Juanni Gong et al.
Background and objectives: The ability of a quality of life (QoL) to guide balloon pulmonary angioplasty (BPA) among patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) has not been fully invest...
Development and status quo of digestive endoscopy in China: An analysis based on the national census in 2013 and 2020 [0.03%]
我国消化内镜的发展与现状分析：基于2013和2020年全国普查数据
Yunfei Jiao,Zhiyuan Cheng,Ye Gao et al.
Yunfei Jiao et al.
Background and objectives: Technique and practice of digestive endoscopy are undergoing speedy development all over the world. This study aimed to evaluate its status quo and development in China. ...
Microarray analysis of microrna expression in peripheral blood mononuclear cells of patients with polymyositis and dermatomyositis [0.03%]
多肌炎和皮肌炎患者外周血单个核细胞微小RNAs的表达谱分析研究
Jia Shi,Shuang Zhou,Jiuliang Zhao et al.
Jia Shi et al.
Background and objectives: MicroRNAs (miRNAs) represent a new class of biomarkers in the context of connective tissue disorders. The miRNA expression profiles in peripheral blood mononuclear cells (PBMCs) of patients with...