Unraveling the enigma: Post-translational modifications in psychiatric disorders and their regulatory mechanisms [0.03%]
精神病障碍的翻译后修饰及其调控机制探究
Ting Hu,Yan Liao,Chenwei Huang et al.
Ting Hu et al.
Psychiatric disorders, including schizophrenia, bipolar disorder, and major depressive disorder, are a group of categorical syndromes characterized by significant impairment of an individual's cognition, emotional regulation, or abnormal be...
Immunoglobulin κ drives liver regeneration by stabilizing MYLK to maintain cytoskeletal integrity and promote hepatocyte proliferation [0.03%]
免疫球蛋白κ通过稳定MYLK来维持细胞骨架的完整性并促进肝细胞增殖从而驱动肝脏再生
Huining Gu,Sha Yin,Feng Liu et al.
Huining Gu et al.
Background and objectives: Liver regeneration necessitates coordinated cytoskeletal dynamics, yet the key molecular orchestrators remain incompletely defined. Intriguingly, recent studies reveal a novel role for hepatocyt...
Exercise may serve as a potential preventive strategy for mitochondria influencing the occurrence of heart failure with preserved ejection fraction [0.03%]
运动可能是一种潜在的预防策略，通过影响线粒体的活性来减少射血分数保留型心力衰竭的发生率
Lin Zheng,Zhengkai Wang,Xuezheng Xuan et al.
Lin Zheng et al.
Dual role of intratumoral microbiota: From colorectal cancer progression to therapeutic opportunities [0.03%]
肿瘤内微生物的双重作用：从结直肠癌的发生发展到治疗应用
Anqi Lin,Xiuhui Fang,Lingxuan Zhu et al.
Anqi Lin et al.
Inflammation, metabolism, and aging in heart failure with preserved ejection fraction: Mechanisms and treatment perspectives [0.03%]
心力衰竭合并射血分数保留时的炎症、代谢和衰老：机制及治疗展望
Yaqun Teng,Weikang Bian,Qingyu Li et al.
Yaqun Teng et al.
Heart failure with preserved ejection fraction (HFpEF) is an increasingly prevalent clinical syndrome with limited effective therapies, representing a major unmet need in cardiovascular medicine. A comorbidity-driven systemic proinflammator...
Joint association of the frailty index and phenotypic age with all-cause and cause-specific mortality: A prospective cohort study [0.03%]
脆弱指数和表型年龄与全因死亡率和其他原因特异性死亡率联合关联的前瞻性队列研究
Zilun Shao,Yuxuan Zhao,Haiming Yang et al.
Zilun Shao et al.
Background and objectives: Little is known about whether frailty index (FI) and phenotypic age (PhenoAge), two independent indicators of biological age, may jointly or interactively predict death risk. ...
Subphenotyping of prediabetes with a phenotypic tree model and its correlations with outcomes: Insights from two Chinese cohorts [0.03%]
基于表型树模型的糖尿病前期人群亚表型分类及其临床结局分析：两项中国成人队列研究
Jia Zhang,Jing Ma,Zijian Tian et al.
Jia Zhang et al.
Background and objectives: To investigate whether stratifying participants with prediabetes using the Scottish tree model could identify their risks of developing diabetes and related outcomes. ...
To dig oneself into a hole or to dig the tunnel to the core? A study on the Swartz sheath support strategy for patent foramen ovale closure in migraine patients [0.03%]
挖坑还是筑路？卵圆孔未闭封堵术治疗偏头痛患者Swartz鞘支撑策略的探讨
Jianing Fan,Jiaxin Miao,Qixin Chen et al.
Jianing Fan et al.
Objectives: Patent foramen ovale (PFO) closure effectively alleviates symptoms in patients with migraines; however, multipurpose angiographic catheters often encounter difficulty in passing through a small shunt PFO. Here...
Artificial intelligence as a computational kit for digital biomarker discovery [0.03%]
人工智能作为数字生物标志物发现的计算工具包
Shenda Hong,Qiang Zhang,Gongzheng Tang et al.
Shenda Hong et al.
Causal relationships between irritable bowel syndrome and brain functional networks: A Mendelian randomization study [0.03%]
基于孟德尔随机化研究的肠易激综合症与脑功能网络之间的因果关系
Ruqiao Duan,Tao Zhang,Siqi Lu et al.
Ruqiao Duan et al.
Background and objective: The association between irritable bowel syndrome (IBS) and brain function remains unclear. We conducted Mendelian randomization (MR) analysis to investigate the possible causal relationships betw...