Inhibition of heterogeneous nuclear ribonucleoproteins A1 and oxidative stress reduces glycolysis via pyruvate kinase M2 in chronic thromboembolic pulmonary hypertension [0.03%]
异质性核糖核酸蛋白A1和氧化应激通过丙酮酸激酶M2减少慢性血栓栓塞性肺动脉高压的糖酵解作用
Lianhua Liu,Wenyi Pang,Jixiang Liu et al.
Lianhua Liu et al.
Background and objective: Chronic thromboembolic pulmonary hypertension (CTEPH) is a lethal complication of pulmonary embolism involving pulmonary artery occlusion and microvascular disease. The glucose metabolism and rea...
Comprehensive succinylome analyses reveal that hyperthermia upregulates lysine succinylation of annexin A2 by downregulating sirtuin7 in human keratinocytes [0.03%]
全面的琥珀酰化组分析显示高温通过下调长寿蛋白7诱导人类角质形成细胞中的AnxA2赖氨酸琥珀酸化水平
Xueli Niu,Yiping Zhao,Tao Zhang et al.
Xueli Niu et al.
Background and objectives: Local hyperthermia at 44°C can clear multiple human papillomavirus (HPV)-infected skin lesions (warts) by targeting a single lesion, which is considered as a success of inducing antiviral immun...
Recognition of differently expressed genes and DNA methylation markers in patients with Lupus nephritis [0.03%]
狼疮性肾炎患者差异表达基因及DNA甲基化标志物的识别
Zhenjie Liu,Fengxun Liu,Junwei Xie et al.
Zhenjie Liu et al.
Background and objectives: Systemic lupus erythematosus (SLE) is distinguished by dysregulated immune system activity, resulting in a spectrum of clinical manifestations, with lupus nephritis being particularly prominent....
A bibliometric analysis of immune-related adverse events in cancer patients and a meta-analysis of immune-related adverse events in patients with hepatocellular carcinoma [0.03%]
基于癌症免疫相关不良事件的文献计量分析及肝细胞癌患者免疫相关不良事件的 Meta 分析
Bengang Wang,Xiangjun Hao,Jinshan Yan et al.
Bengang Wang et al.
Background and objectives: Immunotherapy has become the standard treatment for hepatocellular carcinoma (HCC), but it carries a risk of immune-related adverse events (irAEs) that can be life-threatening. This study employ...
RN486, a Bruton's Tyrosine Kinase inhibitor, antagonizes multidrug resistance in ABCG2-overexpressing cancer cells [0.03%]
溴结构域蛋白486通过抑制布伦顿酪氨酸激酶来克服ABCG2高表达的肿瘤细胞的多药耐药性
Xing-Duo Dong,Qisi Lu,Yi-Dong Li et al.
Xing-Duo Dong et al.
Background and objectives: Overcoming ATP-binding cassette subfamily G member 2 (ABCG2)-mediated multidrug resistance (MDR) has attracted the attention of scientists because one of the critical factors resulting in MDR in...
Application of body area network wearable smart bracelet in epidemic isolation scenario [0.03%]
可穿戴智能手环在疫情隔离场景中的身体区域网络应用研究
Wei Han,Hongbin Cai,Jiafa Lu et al.
Wei Han et al.
Analysis and prediction of research hotspots and trends in heart failure research [0.03%]
心力衰竭研究热点及趋势的分析与预测
Zeye Liu,Yuan Huang,Yang Yang et al.
Zeye Liu et al.
Background and objectives: Comprehensive data analyses in heart failure research can provide academics with information and help policymakers formulate relevant policies. We collected data from reports published between 1...
Treatment strategies with combined agency against severe viral pneumonia in patients with advanced cancer [0.03%]
针对晚期恶性肿瘤患者的重症病毒性肺炎的联合体机构治疗策略
Fan Zhang,Tao Li,Yibing Bai et al.
Fan Zhang et al.
Associations of gallbladder and gallstone parameters with clinical outcomes in patients with cirrhosis [0.03%]
肝硬化患者胆囊和胆结石参数与临床结局的相关性
Min Ding,Yue Yin,Xueying Wang et al.
Min Ding et al.
Background: Morphologic changes in the gallbladder and gallstones are common in cirrhotic patients, but their associations with outcomes of cirrhotic patients are unclear. ...
Nomogram for predicting risk of mild renal dysfunction among general residents from rural Northeast China [0.03%]
中国东北农村地区居民轻度肾功能不全风险预测列线图
Shasha Yu,Hongmei Yang,Bo Wang et al.
Shasha Yu et al.
Background and objectives: Cumulative evidence confirms that mild renal dysfunction (MRD) is correlated with many cardiovascular risk factors and increases cardiovascular morbidity and mortality. The purpose of this study...