Integrated untargeted/targeted metabolomics identifies a putative oxylipin signature in patients with atrial fibrillation and coronary heart disease [0.03%]
整合无靶标/有靶标代谢组学鉴定出房颤和冠心病患者中一种潜在的氧脂素标志物
Lei Li,Yingyuan Lu,Zhiyong Du et al.
Lei Li et al.
Background and objective: Atrial fibrillation (AF) and coronary heart disease (CHD) are closely related to metabolic dysregulation. However, the metabolic characteristics of AF patients with concomitant CHD remain unclear...
Inetetamab for injection in combination with vinorelbine weekly or every three weeks in HER2-positive metastatic breast cancer: A multicenter, randomized, phase II clinical trial [0.03%]
注射用伊纳维昔单抗联合每周或每三周一次的长春瑞滨治疗HER2阳性转移性乳腺癌：一项多中心随机Ⅱ期临床试验
Xiying Shao,Ning Xie,Zhanhong Chen et al.
Xiying Shao et al.
Objective: We aimed to investigate the pharmacokinetics, safety, efficacy, and immunogenicity of different dosing regimens (weekly and every three weeks) of inetetamab in combination with vinorelbine in human epidermal gr...
Histological transformation in lung adenocarcinoma: Insights of mechanisms and therapeutic windows [0.03%]
肺腺癌的组织学转化：机制及治疗窗口的启示
Nuopei Tan,Yan Li,Jianming Ying et al.
Nuopei Tan et al.
Histological transformation from lung adenocarcinoma (ADC) to small cell lung carcinoma (SCLC), large cell neuroendocrine carcinoma (LCNEC), squamous cell carcinoma (SCC), and sarcomatoid carcinoma (PSC) after targeted therapies is recogniz...
Gastroesophageal reflux disease influences blood pressure components, lipid profile and cardiovascular diseases: Evidence from a Mendelian randomization study [0.03%]
遗传随机化研究证明胃食管反流病影响血压成分、血脂状况和心血管疾病
Qiang Wu,Changjing He,Wanzhong Huang et al.
Qiang Wu et al.
Background: Gastroesophageal reflux disease (GERD) is a prevalent gastrointestinal disorder associated with a range of cardiovascular and metabolic complications. However, the relationship between GERD and blood pressure ...
Jian Wu,Huiqing Wang,Ze Xiang et al.
Jian Wu et al.
Hepatitis viral infection can cause severe complications, even mortality in pregnant women and their offspring. Multiple studies have shown that vertical transmission can cause viral hepatitis infections in newborns, especially in hepatitis...
Machine learning-based phenogroups and prediction model in patients with functional gastrointestinal disorders to reveal distinct disease subsets associated with gas production [0.03%]
基于机器学习的表型分组和功能胃肠病患者的预测模型以揭示与产气相关的不同疾病亚群
Lingling Zhu,Shuo Xu,Huaizhu Guo et al.
Lingling Zhu et al.
Background and objectives: Symptom-based subtyping for functional gastrointestinal disorders (FGIDs) has limited value in identifying underlying mechanisms and guiding therapeutic strategies. Small intestinal dysbiosis is...
Chinese expert consensus on blood lipid management in patients with diabetes (2024 edition) [0.03%]
中国糖尿病患者血脂管理专家共识（2024版）
Yang Xiao,Bilian Yu,Chen Chao et al.
Yang Xiao et al.
Diabetes is a significant independent risk factor for atherosclerotic cardiovascular disease (ASCVD), with dyslipidemia playing a critical role in the initiation and progression of ASCVD in diabetic patients. In China, the current prevalenc...
Identification of functional heterogeneity of immune cells and tubular-immune cellular interplay action in diabetic kidney disease [0.03%]
糖尿病肾脏疾病中免疫细胞功能异质性及肾小管-免疫细胞相互作用识别
Yunfeng Bai,Kun Chi,Delong Zhao et al.
Yunfeng Bai et al.
Background: Renal inflammation plays key roles in the pathogenesis of diabetic kidney disease (DKD). Immune cell infiltration is the main pathological feature in the progression of DKD. Sodium glucose cotransporter 2 inhi...
Actin-related protein 2/3 complex subunit 1B promotes ovarian cancer progression by regulating the AKT/PI3K/mTOR signaling pathway [0.03%]
Actin相关蛋白2/3复合体亚基1B通过调节AKT/PI3K/mTOR信号通路促进卵巢癌进展
Miao Ke,Huimin Zhu,Yu Lin et al.
Miao Ke et al.
Background and objectives: Actin-related protein 2/3 complex subunit 1B (ARPC1B) is an essential subunit of the actin-related protein 2/3 (Arp2/3) complex. While there have been numerous research reports on Arp2/3 in rela...
PRP improves the outcomes of autologous skin graft transplantation on the esophagus by promoting angiogenesis and inhibiting fibrosis and inflammation [0.03%]
富血小板血浆通过促进血管生成和抑制纤维化及炎症改善自体皮肤移植修复食管的效果
Ning Xu,Longsong Li,Jiale Zou et al.
Ning Xu et al.
Background and objectives: Autologous skin graft (ASG) transplantation is a challenging approach but a promising option for patients to prevent postoperative esophageal stricture. Nonetheless, the current strategies requi...