Development of a broadly potent neutralizing antibody targeting Nidogen 1 effectively inhibits cancer growth and metastasis in preclinical tumor models [0.03%]
靶向巢蛋白1的广泛中和抗体的发展有效抑制了临床前肿瘤模型中的癌症生长和转移
Tingmao Xue,Cherlie Lot Sum Yeung,Xiaowen Mao et al.
Tingmao Xue et al.
Background and objectives: Nidogen 1 (NID1) is a highly conserved structural component of the extracellular matrix (ECM), which interacts with different basement membrane (BM) proteins to form a stabilized meshwork. The p...
Reperfusion therapy for acute ischemic stroke: Where we are and where to go [0.03%]
急性缺血性卒中的再灌注治疗：目前进展和未来方向
Siying Fan,Lu Yang,Xunming Ji
Siying Fan
Senescent cells as a target for anti-aging interventions: From senolytics to immune therapies [0.03%]
衰老细胞作为抗衰老干预的靶标：从senolytics到免疫疗法
Tianlu Esther Fu,Zhongjun Zhou
Tianlu Esther Fu
Aging and age-related diseases are major drivers of multimorbidity and mortality worldwide. Cellular senescence is a hallmark of aging. The accumulation of senescent cells is causally associated with pathogenesis of various age-associated d...
An international survey on the geographical differences in practice patterns and training of endoscopic ultrasound [0.03%]
一项关于内镜超声实践模式和培训的地域差异的国际调查研究
Tobias Kleemann,Robert Freund,Barbara Braden et al.
Tobias Kleemann et al.
Background and objectives: Recently, a series of publications discuss what kind of clinical and technical information is important to know before performing endoscopic ultrasound (EUS) examinations. This paper aims to inv...
Targeting regulated cell death: Apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis in anticancer immunity [0.03%]
调节的细胞死亡靶点：在抗癌免疫中的凋亡、焦亡、炎性 Caspase 依赖性细胞焦亡、铁死亡和铜死亡
Ziyu Guo,Yihuang Liu,Danyao Chen et al.
Ziyu Guo et al.
In the evolving landscape of cancer treatment, the strategic manipulation of regulated cell death (RCD) pathways has emerged as a crucial component of effective anti-tumor immunity. Evidence suggests that tumor cells undergoing RCD can modi...
Xiao-Qian Hu,Guifang Zhang,Liping Zhao et al.
Xiao-Qian Hu et al.
Glymphatic function decline as a mediator of core memory-related brain structures atrophy in aging [0.03%]
淋巴功能下降作为老龄化过程中核心记忆相关大脑结构萎缩的中介因素
Shan Chong,Sanwang Wang,Teng Gao et al.
Shan Chong et al.
Background and objectives: This study aimed to elucidate the role of the glymphatic system-a crucial pathway for clearing waste in the brain-in the aging process and its contribution to cognitive decline. We specifically ...
Current applications and future perspectives of artificial intelligence in valvular heart disease [0.03%]
人工智能在瓣膜性心脏病中的当前应用及未来展望
Luying Jiang,Houjuan Zuo,Xin Joy Wang et al.
Luying Jiang et al.
Spatiotemporal analysis of the effects of exercise on the hemodynamics of the aorta in hypertensive rats using fluid-structure interaction simulation [0.03%]
基于流固耦合模拟的运动对高血压大动脉血流动力学影响的时空分析
Yueshen Wang,Haiyi Yu,Quanyou Shi et al.
Yueshen Wang et al.
Background and objective: Hemodynamic changes that lead to increased blood pressure represent the main drivers of organ damage in hypertension. Prolonged increases to blood pressure can lead to vascular remodeling, which ...
Shantong Jiang,Hongyan Shi,Yanqing Hu et al.
Shantong Jiang et al.