Lung adenocarcinoma-specific three-integrin signature contributes to poor outcomes by metastasis and immune escape pathways [0.03%]
肺腺癌特异的三种整合素标志物通过转移和免疫逃逸通路导致不良预后
Yizhe Wang,Kezuo Hou,Yue Jin et al.
Yizhe Wang et al.
Background: Inhibitors targeting integrins (ITGs) are applied as a novel strategy for cancers including lung cancer; however, the heterogeneity of ITG subunits might explain why ITG-targeted inhibitors only show limited e...
Menglin Zhu,Qian Ding,Zhongxiao Lin et al.
Menglin Zhu et al.
Vascular senescence plays a vital role in cardiovascular diseases and it is closely related to cellular senescence. At the molecular level, aging begins with a single cell, and it is characterized by telomere shortening, mitochondrial dysfu...
The challenges and optimization of cell-based therapy for cardiovascular disease [0.03%]
细胞治疗心血管疾病面临的挑战与优化路径
Shiyue Xu,Yumin Qiu,Jun Tao
Shiyue Xu
With the hope of achieving real cardiovascular repair, cell-based therapy raised as a promising strategy for the treatment of cardiovascular disease (CVD) in the past two decades. Various types of cells have been studied for their reparativ...
Keran Sun,Huifang Lv,BeiBei Chen et al.
Keran Sun et al.
Translational research in anti-pancreatic fibrosis drug discovery and development [0.03%]
抗胰腺纤维化药物研发的转化研究
Xingyu Ze,Wenbin Zou,Zhaoshen Li
Xingyu Ze
The Prognostic Value of Krebs von den Lungen-6 and Surfactant Protein-A Levels in the Patients with Interstitial Lung Disease [0.03%]
KL-6和SP-A水平对间质性肺疾病患者的预后价值分析
Peiyan Zheng,Xiaomao Zheng,Hasegawa Takehiro et al.
Peiyan Zheng et al.
Background and objectives: The highly variable clinical course of interstitial lung disease (ILD) makes it difficult to predict patient prognosis. Serum surfactant protein-A (SP-A) and Krebs von den Lungen-6 (KL-6) are kn...
The Lifetime Cost Estimation of Human Papillomavirus-related Diseases in China: A Modeling Study [0.03%]
中国HPV相关疾病 lifetime 负担估计模型研究
Wenpei Ding,Yue Ma,Chao Ma et al.
Wenpei Ding et al.
Objectives: To estimate the lifetime treatment costs of patients with human papillomavirus (HPV) infection-related diseases in China and to provide cost estimates for the economic evaluation of HPV intervention strategies...
Repositioning of Fungal-based Peptides as Modulators of Angiotensin-converting Enzyme-related Carboxypeptidase, SARS-coronavirus HR2 Domain, and Coronavirus Disease 2019 Main Protease [0.03%]
基于真菌的肽类化合物作为血管紧张素转化酶相关羧基末端肽酶、SARS冠状病毒HR2区和冠状病毒感染疾病主要蛋白酶调节剂的作用机制重塑
Babatunde Joseph Oso,Clement Olusola Ogidi
Babatunde Joseph Oso
Background and objectives: Angiotensin-converting enzyme-related carboxypeptidase, SARS-Coronavirus HR2 Domain, and COVID-19 main protease are essential for the cellular entry and replication of coronavirus in the host. T...