A newly-synthesized compound CP-07 alleviates microglia-mediated neuroinflammation and ischemic brain injury via inhibiting STAT3 phosphorylation [0.03%]
一种新合成的化合物CP-07通过抑制STAT3磷酸化缓解小胶质细胞介导的神经炎症和缺血性脑损伤
Mengdi Guo,Qian Cao,Shengnan Xia et al.
Mengdi Guo et al.
Background and objectives: Overactivated glial cells, especially microglia, are core components in the progression of pathologic neuroinflammation, and the application of anti-inflammatory reagents has been regarded as a ...
Timing of anticoagulation for the management of portal vein thrombosis in liver cirrhosis [0.03%]
抗凝治疗肝硬化门静脉血栓的最佳时机研究进展
Emanuele Valeriani,Pasquale Pignatelli,Marco Senzolo et al.
Emanuele Valeriani et al.
Adrenomedullin induces cisplatin chemoresistance in ovarian cancer through reprogramming of glucose metabolism [0.03%]
肾上腺髓质素通过重新编程葡萄糖代谢诱导卵巢癌的顺铂耐药性
Lei Dou,Enting Lu,Dongli Tian et al.
Lei Dou et al.
Background and objectives: The metabolic network of cancer cells has been reprogrammed - relying more on aerobic glycolysis to gain energy, which is an important reason for drug resistance. Expression of adrenomedullin (A...
Serum myoglobin modulates kidney injury via inducing ferroptosis after exertional heatstroke [0.03%]
横纹肌溶解症患者血清肌红蛋白致肾损伤可能与其诱导肾细胞铁死亡有关
Yingyi Luan,Enping Huang,Jiajia Huang et al.
Yingyi Luan et al.
Background and objectives: Myoglobin released by rhabdomyolysis (RM) is considered to be involved in pathogenesis of kidney disease caused by crush injury, but whether high level of serum myoglobin predisposes patients to...
A cycloruthenated complex, ruthenium (II) Z (RuZ) overcomes in vitro and in vivo multidrug resistance in cancer cells: A pivotal breakthrough [0.03%]
一种环钌化合物RUZ克服癌细胞体外及体内多重耐药性：一个关键突破
Luqi Cao,Yuhao Xie,Zhesheng Chen et al.
Luqi Cao et al.
Weisheng Chen,Miaoxian Fang,Chunbo Chen
Weisheng Chen
Therapeutic potential and mechanisms of sacral nerve stimulation for gastrointestinal diseases [0.03%]
骶神经刺激治疗胃肠疾病的潜力及机制研究
Ximeng Wang,Jiande Dz Chen
Ximeng Wang
Background: The aim of this systemtic review is to introduce clinical applications (especially emerging) and potential mechanisms of sacral nerve stimulation (SNS) for treating various gastrointestinal diseases. ...
The evolution of folate supplementation - from one size for all to personalized, precision, poly-paths [0.03%]
叶酸补充的演变——从“一刀切”到个性化、精准化、多元化路径
Qiangqiang He,Jianping Li
Qiangqiang He
Folate is a crucial nutrient that supports physiological functions. Low folate levels is a risk factor for several diseases, including cardiovascular diseases and neural tube defects. The most used folate supplement is folic acid, a synthet...
Suggestions on home quarantine and recovery of novel coronavirus patients [0.03%]
关于新冠肺炎患者居家隔离和康复的建议
Qiuyu Li,Chengyang Liu,Haiyun Li
Qiuyu Li